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61,005 resultsShowing papers similar to Expanding adverse outcome pathways towards one health models for nanosafety
ClearA One Health Perspective and Introduction
This review introduces a One Health framework for understanding the toxicological risks of engineered nanoparticles, ultrafine particulates, and micro- and nanoplastic contaminants, arguing that their impacts on natural environments and human health are interconnected and require integrated ecological, ecotoxicological, and clinical research approaches.
Time to integrate “One Health Approach” into nanoplastic research
This commentary argues that nanoplastic research needs to adopt a "One Health" framework that considers the health of humans, animals, and ecosystems as deeply interconnected rather than studying each in isolation. Applying this approach could lead to more comprehensive and actionable findings about how nanoplastics affect living systems across scales.
Paradigms to assess the human health risks of nano- and microplastics
Researchers proposed a new, comprehensive framework for assessing the health risks of nano- and microplastics (tiny plastic particles), addressing key gaps in how we analyze these particles, model their behavior, and use that information to protect human health — since no such standard risk assessment system currently exists.
Invisible Contamination: a One Health Perspective on Micro and Nanoplastics
This systematic review takes a One Health approach to examine how micro- and nanoplastics affect humans, animals, and the environment as interconnected systems. The research shows that plastics accumulate across food chains and can cause toxic effects in multiple species, including humans. The One Health perspective is important because it recognizes that microplastic pollution in the environment inevitably becomes a human health problem.
The ocean and microplastics: a One Health approach
This paper examines ocean microplastic pollution through a One Health framework, connecting marine ecosystem contamination to animal and human health impacts by tracing microplastic pathways from ocean sources through food webs to human exposure. The approach integrates ecological, veterinary, and public health perspectives to argue for a unified response to microplastic pollution as a cross-cutting environmental health challenge.
A review on effects of microplastics on animal, environment and human health considering One Health perspective
This review examines the effects of microplastics on animal, environmental, and human health from a One Health perspective, highlighting how microplastic contamination interconnects ecological, animal, and human health systems.
Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment
Researchers reviewed the evolving field of nanosafety, examining approaches to evaluate the potential toxicity and risks of nanomaterials used across industries including cosmetics, pharmaceuticals, food, and agriculture. The study discusses how traditional toxicological methods are being adapted alongside new nanotoxicology approaches to assess immunotoxicity and genotoxicity of nanomaterials. The review highlights the need for comprehensive safety frameworks as the rapid development of new nanomaterials continues to outpace our understanding of their potential health effects.
Key knowledge gaps for One Health approach to mitigate nanoplastic risks
Researchers identified critical knowledge gaps in understanding nanoplastic risks, arguing that nanoplastics — plastic particles smaller than 1 micrometer — should be treated as complex mixtures carrying chemical additives and contaminants, and calling for a coordinated "One Health" approach that links environmental, animal, and human health research.
Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment
This review provides an overview of nanosafety as an evolving field, covering toxicological assessment methods, nanotoxicology approaches, and new technologies including organ-on-chip systems and biosensors. The authors discuss Life Cycle Assessment as an increasingly important nanosafety tool for evaluating the environmental impact of nanomaterials from production through disposal.
Environmental pollution and One Health: An integrated threat to global health
This review examines environmental pollution through the One Health framework, which recognizes the interconnectedness of human, animal, and environmental health. Researchers found that pollutants including heavy metals, microplastics, and chemical contaminants circulate continuously between ecosystems, animals, and human populations, creating cascading health effects. The study calls for integrated, cross-disciplinary approaches to address pollution as a shared threat across all domains of health.
A One Health perspective of the impacts of microplastics on animal, human and environmental health
This review takes a "One Health" approach to microplastics, examining how they affect animal health, human health, and the environment as interconnected systems. The authors caution that many lab studies use microplastic concentrations far higher than what is found in nature, making their results hard to apply to real-world risk. However, they note that microplastics can indirectly affect human health by disrupting ecosystems and soil processes that support food production and clean water.
Leveraging nanoparticle environmental health and safety research in the study of micro- and nano-plastics
Researchers argue that two decades of research on the environmental health and safety of engineered nanomaterials provides a strong foundation for studying micro- and nanoplastics. They outline how lessons from nano-safety research apply to understanding plastic particle toxicity, bioaccumulation, trophic transfer, and environmental behavior. The study emphasizes that existing tools and methodologies from nanotoxicology can accelerate progress in assessing the risks of particulate plastic pollution.
Tackling the microplastics pandemic: the CLEAN framework as an integrated one health approach for global environmental and public health
This paper introduces the CLEAN framework as an integrated One Health approach for addressing microplastic pollution across environmental, animal, and human health domains. Researchers argue that current responses to microplastic contamination are fragmented and propose a systematic risk assessment and prevention strategy analogous to occupational health management. The framework aims to bridge gaps between environmental science, public health policy, and community-level action on microplastic exposure.
Microplastic toxicity: mechanisms, assessment methods, and future research directions
This review synthesizes current knowledge on microplastic toxicity mechanisms, integrating physical, chemical, and biological pathways into a unified framework. Researchers examined assessment methods across aquatic organisms, terrestrial species, and human cell models, identifying critical knowledge gaps and recommending standardized approaches for future microplastic toxicity research.
Oral exposure to micro- and nanoplastics: Developing a modular and flexible risk assessment framework for human health
Researchers proposed a modular and flexible risk assessment framework for evaluating the human health risks of oral exposure to micro- and nanoplastics. The framework integrates modern concepts such as Integrated Approaches to Testing and Assessment and Adverse Outcome Pathways, providing a systematic method for addressing the complexity and diversity of these materials.
Adverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing
Researchers proposed using the adverse outcome pathway framework to systematically assess microplastic hazards to human health, identifying mechanistic parallels with other well-characterized stressors that can guide prioritization of in vitro testing strategies for particles of different sizes, shapes, and chemistries.
Microplastics, the Trojan Horse Paradigm: Barriers to Traditional Toxicological Risk Assessment and Opportunities for NAMs.
This review argued that microplastics behave like a "Trojan horse," carrying adsorbed chemicals into biological systems in ways that undermine traditional toxicological risk assessment frameworks. The authors identified key gaps in exposure data and toxicokinetics and proposed that new approach methodologies (NAMs) are needed to adequately assess microplastic hazards.
Microplastics, the Trojan Horse Paradigm: Barriers to Traditional Toxicological Risk Assessment and Opportunities for NAMs.
This review argued that microplastics behave like a "Trojan horse," carrying adsorbed chemicals into biological systems in ways that undermine traditional toxicological risk assessment frameworks. The authors identified key gaps in exposure data and toxicokinetics and proposed that new approach methodologies (NAMs) are needed to adequately assess microplastic hazards.
Nano/micro-plastics: Sources, trophic transfer, toxicity to the animals and humans, regulation, and assessment
This review comprehensively covered the sources, trophic transfer pathways, toxicity to animals and humans, and regulatory status of nano- and microplastics, synthesizing evidence that these particles are broadly distributed and cause harm across multiple biological levels. The authors called for improved global regulatory frameworks given the pace at which exposure evidence is accumulating.
Exposure and Possible Risks of Engineered Nanomaterials in the Environment—Current Knowledge and Directions for the Future
This 15-year retrospective of engineered nanomaterial (ENM) environmental research found that the field has progressed from observation of effects to mechanistic understanding, with advances in fate modeling and ecotoxicological assessment, but that material-specific risk assessment remains an ongoing challenge.
Prioritising nano- and microparticles: identification of physicochemical properties relevant for toxicity to Raphidocelis subcapitata and Daphnia magna
Ecotoxicity data for 36 nano- and microparticles of diverse inorganic compositions were generated and used to develop a prioritization framework for identifying which advanced materials pose the greatest human and environmental hazard. The approach provides a practical tool for risk-based regulation of the expanding universe of engineered nano- and microparticles.
Dioxins and the One Health Paradigm: An Interdisciplinary Challenge in Environmental Toxicology
This review applies a One Health framework to examine the sources, environmental fate, and toxic effects of dioxins across human, animal, and ecosystem health. The study highlights that dioxins, as persistent environmental pollutants, accumulate through food webs and exert harmful effects even at low concentrations, and calls for integrated monitoring and policy approaches to address persistent gaps in surveillance and regulation.
Precision Nanotoxicology in Drug Development: Current Trends and Challenges in Safety and Toxicity Implications of Customized Multifunctional Nanocarriers for Drug-Delivery Applications
This review highlights the growing gap between the rapid commercialization of multifunctional nanocarriers for drug delivery and our limited understanding of their long-term toxicity in humans and the environment. Standardized nanotoxicology frameworks are urgently needed to evaluate safety before widespread clinical adoption.
Aquatic one health framework: Integrating ocean ecosystems and human well-being
This paper introduces an Aquatic One Health framework that integrates ocean ecosystem health with human and animal wellbeing, discussing how marine pollutants including microplastics form interconnected threats that require coordinated environmental and public health responses.