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Leveraging nanoparticle environmental health and safety research in the study of micro- and nano-plastics

NanoImpact 2024 2 citations

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Researchers argue that two decades of research on the environmental health and safety of engineered nanomaterials provides a strong foundation for studying micro- and nanoplastics. They outline how lessons from nano-safety research apply to understanding plastic particle toxicity, bioaccumulation, trophic transfer, and environmental behavior. The study emphasizes that existing tools and methodologies from nanotoxicology can accelerate progress in assessing the risks of particulate plastic pollution.

Lessons learned, methodologies, and application of tools that have been developed within the context of research on the environmental impacts, health, and safety of nanomaterials (nano-EHS) provide a solid foundation for research on nano/microplastics. In this communication, we summarize key discoveries obtained through major research efforts over the last two decades in the area of nano-EHS that are applicable for the study of micro- and nano-plastics (referred to here more generally as particulate plastics). We focus on how non-equilibrium particle transport processes affect: 1) bio-physico-chemical mechanisms of particle toxicity and determining dose-response relationships; 2) the potential for biouptake, bioaccumulation, translocation, trophic transfer and intergenerational effects of particulate contaminants; 3) extrapolations from laboratory experiments to complex systems and the impact of environmental transformations; 4) the formulation of functional assays as a basis for predicting the impacts of particulate contaminants in complex environments; 5) the relative importance of incidental particles compared with engineered particles and, 6) experience with data platforms, curation, and experimental design.

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