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Gut & Microbiome
6,526 resultsBirds as Bioindicators: Revealing the Widespread Impact of Microplastics
This systematic review found microplastics in over 200 bird species across the globe, from Antarctica to South Europe. Birds can suffer gut damage, oxidative stress, and toxic chemical buildup from ingesting plastics — a warning sign for broader ecosystem and food chain contamination that could affect humans too.
Meta-analysis of the effects of microplastic on fish: Insights into growth, survival, reproduction, oxidative stress, and gut microbiota diversity
A meta-analysis of 3,757 biological endpoints from 85 studies found that microplastic exposure significantly inhibits fish growth, survival, and reproduction while increasing oxidative damage, but does not significantly alter gut microbiota diversity. The severity of toxic effects depends on microplastic type, size, concentration, exposure pathway, and the fish's life stage.
Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review
This systematic review examined studies on how microplastic exposure affects human digestive, reproductive, and respiratory health. Early evidence suggests links to gut inflammation, reproductive issues, and lung irritation, though the review notes that more high-quality human studies are urgently needed.
Microplastics comprehensive review: Impact on honey bee, occurrence in honey and health risk evaluation
This systematic review examines how microplastics contaminate honey through bees and their environment. The findings show that bees accumulate microplastics from polluted air, water, and soil, which can then end up in honey — a product many people consume for its health benefits.
Non-degradable microplastic promote microbial colonization: A meta-analysis comparing the effects of microplastic properties and environmental factors
This meta-analysis found that non-degradable microplastics — particularly PVC and polystyrene — support significantly more microbial colonization and biofilm formation than degradable plastics. Smaller particles were more conducive to colonization, and environmental factors like temperature, salinity, and exposure duration became increasingly important over time, with ocean microplastics forming biofilms more easily than those in lakes.
Impact of microplastics on the human gut microbiome: a systematic review of microbial composition, diversity, and metabolic disruptions
This systematic review of 12 studies found that microplastics including polyethylene, polystyrene, and PVC induce gut dysbiosis in humans, reducing beneficial bacteria and enriching pathogens. Microplastic exposure also impairs short-chain fatty acid production and modulates immune pathways, contributing to intestinal disease, metabolic syndrome, and chronic inflammation.
Risk Assessment of Microplastics in Humans: Distribution, Exposure, and Toxicological Effects
This meta-analysis tracked the rapid growth of research on microplastics and human health, finding a shift from studying environmental pollution toward understanding direct human exposure and health effects. Emerging concerns include reproductive toxicity, neurotoxicity, and immune system disruption from microplastic exposure.
Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
This Mendelian randomization study found genetic evidence supporting a causal relationship between specific gut microbiota compositions and gastrointestinal diseases. The findings suggest that microbiome-related interventions, including microbiome-dependent metabolites, could potentially be developed to treat or manage gastrointestinal conditions.
Microplastics in seafood: Navigating the silent health threat and intestinal implications through a One Health food safety lens
This systematic review and meta-analysis found microplastic contamination across fish, crustaceans, and mollusks globally, with flathead lobsters from Iran carrying the highest individual load (460 MPs per animal). PET fibers in the 100-1500 micron range were the most common type, and microplastics were shown to alter gut microbial communities, increase intestinal permeability, and promote inflammation.
Comprehensive meta-analysis reveals the impact of non-biodegradable plastic pollution on methane production in anaerobic digestion
This meta-analysis found that microplastics and nanoplastics interfere with anaerobic digestion, a process used to treat organic waste and produce methane. Smaller nanoplastics had a greater impact, suggesting that plastic contamination in waste could reduce the efficiency of this important waste treatment and energy recovery method.
Microplastics predominantly affect gut microbiota by altering community structure rather than richness and diversity: A meta-analysis of aquatic animals
A phylogenetically controlled meta-analysis of 63 studies across 31 aquatic species found that microplastics significantly alter gut microbiota community structure — with between-group distances 87.75% higher than within-group distances — even at environmentally relevant concentrations. However, microplastics did not significantly affect species richness or Shannon diversity, indicating structural reorganization rather than diversity loss.
Tissue accumulation of microplastics and potential health risks in human
Researchers analyzed human tissues and found microplastics in every sample tested, with lungs containing the highest concentration at about 14 particles per gram, followed by the small intestine, large intestine, and tonsils. PVC was the most common plastic type found, and women had significantly more microplastic particles than men, raising concerns about long-term health effects.
The potential impact of nano- and microplastics on human health: Understanding human health risks.
This review summarizes how nano- and microplastics enter the human body through breathing, eating, drinking, and skin contact, and then accumulate in organs over time. Studies have linked this buildup to respiratory problems like asthma and lung cancer, gut inflammation, disrupted gut bacteria, and neurological symptoms. At the cellular level, plastics cause DNA damage and cell death, though more research is needed to fully understand the long-term health risks in humans.
Role of Soil Microbiota Enzymes in Soil Health and Activity Changes Depending on Climate Change and the Type of Soil Ecosystem
This review examines how soil microorganism enzymes drive the cycling of carbon, nitrogen, and phosphorus, and how climate change and farming practices are altering these critical processes. While not focused on microplastics specifically, soil enzyme activity is a key indicator of soil health and can be disrupted by pollutants including plastic particles. Understanding these enzyme systems helps researchers assess how microplastic contamination may affect soil fertility and ecosystem function.
The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies
This systematic review of 16 animal studies found evidence that heavy metal exposure disrupts gut microbiota composition, which may in turn affect brain function through the gut-brain axis. Lead was the most studied metal, and the findings suggest that environmental contaminant-induced gut dysbiosis could mediate neurotoxic effects, a mechanism that may also apply to microplastic exposure.
A review of potential human health impacts of micro- and nanoplastics exposure
This systematic review summarized 133 studies on how micro- and nanoplastics affect human health based on mammalian research. The evidence points to cell damage, inflammation, gut disruption, and reproductive harm, though most studies focused on polystyrene particles and more research is needed on other common plastic types.
Microplastics in soils: A comparative review on extraction, identification and quantification methods
This review compares the various methods scientists use to extract, identify, and measure microplastics in soil, highlighting the strengths and weaknesses of each approach. Soil is a particularly challenging material to work with because its organic matter and complex structure can interfere with accurate microplastic detection. The authors recommend combining multiple techniques and minimizing harsh chemical steps that could accidentally destroy the very plastic particles being measured.
An Overview on Microplastics Hazards to the Marine Ecosystem and Humans’ Health
This overview examines how microplastics contaminate marine environments and threaten both ocean life and human health. Microplastics can be swallowed by marine organisms, pass through intestinal walls, spread to other organs, and carry toxic chemicals up the food chain to humans. The main ways people are exposed include eating contaminated seafood, breathing in airborne particles, and skin contact.
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage
In a mouse study, polystyrene nanoplastics accelerated the development of colon cancer linked to inflammatory bowel disease by disrupting fat metabolism and causing DNA damage in intestinal cells. The nanoplastics also altered gut bacteria and increased intestinal inflammation, suggesting that plastic particle exposure could worsen outcomes for people already at risk for colon cancer.
Polylactic acid microplastics before and after aging induced neurotoxicity in zebrafish by disrupting the microbiota-gut-brain axis
Researchers exposed zebrafish to microplastics made from PLA, a common biodegradable plastic, and found that both new and aged PLA particles caused brain and nerve damage, including sluggish behavior, memory problems, and increased aggression. Aged PLA particles were even more toxic, and the damage appeared to work through disruption of the gut-brain connection, raising concerns about the safety of biodegradable plastics as they break down in water.
Exposure to polyethylene terephthalate micro(nano)plastics exacerbates inflammation and fibrosis after myocardial infarction by reprogramming the gut and lung microbiota and metabolome
Researchers found that PET microplastics and nanoplastics, one of the most common plastic types found in human coronary blood, worsen heart damage after a heart attack. The plastic particles activated an inflammatory pathway (NLRP3) and disrupted the balance of gut and lung bacteria, leading to chronic inflammation and increased scarring of heart tissue. These findings suggest that plastic pollution exposure may make recovery from heart attacks more difficult.
Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs
Researchers found that polystyrene nanoplastics disrupt the gut lining in mice by altering tiny RNA molecules that control the production of protective proteins in the intestinal barrier. The nanoplastics also caused an imbalance in gut bacteria, creating a chain reaction where damaged gut cells release particles that further weaken the intestinal barrier and change the microbiome.
Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut
Researchers discovered that gut bacteria can break down so-called biodegradable PLA microplastics and incorporate the carbon into their own metabolism, fundamentally altering the gut's energy balance. This process reduced beneficial short-chain fatty acids that fuel gut lining cells and caused decreased appetite and weight loss in mice, suggesting that biodegradable plastics may not be as harmless inside the body as assumed.
Effects of micro- and nanoplastic exposure on macrophages: a review of molecular and cellular mechanisms
This review details how macrophages, key immune cells, respond when they engulf micro- and nanoplastics. The particles trigger inflammatory signaling, damage mitochondria and lysosomes, cause excessive production of harmful reactive oxygen species, and can lead to cell death, while in fat tissue they promote fat buildup and insulin resistance.