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61,005 resultsShowing papers similar to Toxic impacts of polystyrene nanoplastics and PCB77 in blunt snout bream: Evidence from tissue morphology, oxidative stress and intestinal microbiome
ClearExposure to polystyrene nanoplastics and PCB77 induced oxidative stress, histopathological damage and intestinal microbiota disruption in white hard clam Meretrix lyrata
Researchers exposed white hard clams to nanoplastics and a type of industrial pollutant called PCB77, both individually and together, and found that the combination caused more severe damage than either pollutant alone. The clams showed increased oxidative stress, tissue damage in their gills and digestive glands, and significant disruption of their gut bacteria. The findings suggest that nanoplastics may worsen the toxic effects of other environmental contaminants in shellfish.
Interactive effects of polystyrene nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonates on the histomorphology, oxidative stress and gut microbiota in Hainan Medaka (Oryzias curvinotus)
Researchers exposed a freshwater fish species to nanoplastics and a fluorinated chemical pollutant, both alone and in combination, and found that the mixture caused more severe tissue damage than either substance alone. The combined exposure harmed gills, liver, and intestines while disrupting antioxidant systems and gut bacteria. The study suggests nanoplastics can worsen the effects of industrial chemicals on aquatic life.
Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus)
Researchers exposed channel catfish to nanoplastics and bisphenol A, both alone and combined, and found the combination caused more severe liver and intestinal damage than either substance alone. The co-exposure also disrupted gut bacteria in ways that amplified toxicity. Since nanoplastics and BPA commonly co-exist in polluted water, their combined effects on aquatic organisms may be worse than what single-pollutant studies suggest.
Co-exposure to polystyrene nanoplastics and mercury synergistically exacerbates toxicity in rare minnow (Gobiocypris rarus) compared to individual exposures
This study found that when nanoplastics and mercury are present together in water, their combined toxic effects on fish are significantly worse than either pollutant alone. Researchers observed that nanoplastics increased mercury accumulation in rare minnow tissue by about 33%, and the combination caused greater gut damage, inflammation, and disruption of beneficial gut bacteria. The findings highlight the importance of considering how multiple pollutants interact, rather than studying them in isolation.
Enhanced neurotoxic effect of PCB-153 when co-exposed with polystyrene nanoplastics in zebrafish larvae
Researchers found that when zebrafish larvae were exposed to both polystyrene nanoplastics and the toxic chemical PCB-153 together, the neurological damage was significantly worse than from either pollutant alone. The combined exposure caused hyperactive swimming behavior and suppressed immune, brain, and detoxification pathways at the genetic level. This is concerning because nanoplastics and persistent organic pollutants frequently co-exist in the environment, meaning their real-world health effects on aquatic life and humans may be greater than studies of single pollutants suggest.
Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.
Effects of chronic co-exposure polystyrene nanoplastics and cadmium on liver function in Prussian carp (Carassius gibelio)
Researchers exposed Prussian carp to polystyrene nanoplastics and cadmium, both individually and together, for 21 days and found that the combination caused significantly worse liver damage than either pollutant alone. The nanoplastics enhanced cadmium accumulation in the liver and amplified oxidative stress, tissue damage, and immune gene activation. The findings demonstrate that nanoplastics and heavy metals can have synergistic toxic effects on aquatic organisms.
Adverse effects of polystyrene nanoplastic and its binary mixtures with nonylphenol on zebrafish nervous system: From oxidative stress to impaired neurotransmitter system
Researchers investigated the individual and combined effects of polystyrene nanoplastics and the industrial chemical nonylphenol on the zebrafish nervous system over 45 days. Both substances induced oxidative stress and disrupted neurotransmitter systems, with combined exposure generally producing more severe effects on glutamate metabolism and brain tissue damage. The study suggests that the interaction between nanoplastics and co-occurring environmental pollutants can amplify neurotoxic effects in fish.
Detrimental effects of individual versus combined exposure to tetrabromobisphenol A and polystyrene nanoplastics in fish cell lines
Researchers tested how combined exposure to the flame retardant tetrabromobisphenol A and polystyrene nanoparticles affects freshwater fish cells. They found that co-exposure to even low concentrations of both pollutants caused subtle changes in cell viability and generated oxidative DNA damage. The study suggests that the interaction between nanoplastics and chemical pollutants in aquatic environments may pose compounding risks to fish health.
Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)
Researchers examined the combined effects of polystyrene microplastics and copper on Nile tilapia and found that co-exposure increased copper accumulation in the liver and caused tissue damage in multiple organs. High concentrations of both contaminants together triggered oxidative stress, inflammation, and shifts in intestinal microbial communities. The study suggests that microplastics can worsen the toxic effects of heavy metals on freshwater fish.
Polystyrene nanoplastic and engine oil synergistically intensify toxicity in Nile tilapia, Oreochromis niloticus
This study found that polystyrene nanoplastics and engine oil together caused much worse damage to Nile tilapia fish than either pollutant alone, triggering severe inflammation, blood cell changes, and oxidative stress. The combined exposure overwhelmed the fish's natural defenses and caused significant organ damage. Since tilapia is a widely consumed fish, this research highlights how mixtures of pollutants in waterways could compound health risks for both aquatic life and humans who eat contaminated seafood.
Polystyrene microplastics exacerbated the toxicity of okadaic acid to the small intestine in mice
Researchers studied the combined effects of polystyrene microplastics and okadaic acid, a marine toxin, on the small intestines of mice. They found that co-exposure significantly worsened intestinal damage compared to either contaminant alone, increasing oxidative stress and disrupting the gut barrier. The study suggests that microplastics may amplify the harmful effects of naturally occurring marine toxins when both are consumed through seafood.
Exacerbated interfacial impacts of nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonate by natural organic matter in adult zebrafish: Evidence through histopathology, gut microbiota, and transcriptomic analysis
In a zebrafish study, nanoplastics combined with a fluorinated chemical pollutant and natural organic matter caused more severe liver and intestinal damage than any single pollutant alone. The mixture triggered greater oxidative stress, gut inflammation, and harmful changes to gut bacteria. This research shows that in the real world, where nanoplastics mix with other pollutants, the combined health effects may be worse than studies of individual chemicals suggest.
Toxic effects of nanoplastics and microcystin-LR coexposure on the liver-gut axis of Hypophthalmichthys molitrix
Scientists exposed silver carp to both polystyrene nanoplastics and microcystin-LR (a toxin from harmful algae) and found the combination caused more severe gut and liver damage than either pollutant alone. The nanoplastics shortened intestinal structures, changed gut bacteria communities, and disrupted liver metabolism. This is concerning because both contaminants are commonly found together in aquaculture waters, and the fish affected are widely consumed by people.
Nanoplastics enhance the intestinal damage and genotoxicity of sulfamethoxazole to medaka juveniles (Oryzias melastigma) in coastal environment
Scientists exposed young medaka fish to the antibiotic sulfamethoxazole and polystyrene nanoplastics, both individually and together, to study their combined effects on intestinal health. They found that co-exposure caused more severe gut damage than either pollutant alone, disrupting the gut microbiome and triggering changes in gene expression related to immune defense and DNA repair. The study suggests that nanoplastics may amplify the harmful effects of antibiotics on fish in coastal environments.
Concurrent impacts of polystyrene nanoplastic exposure and Aeromonas hydrophila infection on oxidative stress, immune response and intestinal microbiota of grass carp (Ctenopharyngodon idella)
Researchers studied the combined effects of polystyrene nanoplastics and a bacterial infection on grass carp, a common freshwater fish. They found that nanoplastic exposure worsened the impact of the infection by increasing oxidative stress, suppressing immune responses, and disrupting the gut microbiome. The study suggests that nanoplastic pollution in waterways could make fish more vulnerable to disease by weakening their natural defenses.
Co-exposure to polystyrene microplastics and perfluorooctanoic acid can exacerbate lipid metabolism disorders and liver damage in adult zebrafish
Researchers exposed zebrafish to polystyrene microplastics and the persistent pollutant PFOA separately and together for 28 days, finding that combined exposure caused greater intestinal barrier breakdown, liver damage, lipid metabolism disruption, and gut microbiome dysbiosis than either contaminant alone — raising concerns about nonalcoholic fatty liver disease risk from co-occurring plastic and chemical pollution.
Immunotoxicity of microplastics and polychlorinated biphenyls alone or in combination to Crassostrea gigas
Researchers exposed oysters to microplastics and PCBs (industrial chemicals) both alone and together, finding that the combination caused significantly worse immune damage than either pollutant on its own. The pollutants reduced the oysters' ability to fight infection, increased cell damage, and triggered cell death pathways. This synergistic effect is concerning because microplastics in the ocean often carry other toxic chemicals, potentially making contaminated seafood a greater health risk.
Gut microbiota related response of Oryzias melastigma to combined exposure of polystyrene microplastics and tetracycline
Researchers exposed estuarine fish to polystyrene microplastics and the antibiotic tetracycline, both alone and in combination, for four weeks. The combined exposure caused more severe disruption to gut bacteria and liver tissue than either pollutant alone, with microplastics appearing to worsen the effects of tetracycline. The study suggests that the co-occurrence of microplastics and antibiotics in coastal waters may pose greater ecological risks than either contaminant by itself.
Integration of physiology, microbiota and metabolomics reveals toxic response of zebrafish gut to co-exposure to polystyrene nanoplastics and arsenic
Researchers exposed zebrafish to arsenic combined with polystyrene nanoplastics and found that the nanoplastics significantly increased arsenic accumulation in the gut, by up to 77% at the higher dose. The combined exposure caused more oxidative damage and greater disruption to gut bacteria and metabolism than arsenic alone. This study shows that nanoplastics can make other environmental pollutants more dangerous by helping them accumulate in the digestive system.
Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines
When human intestinal cells were exposed to both polystyrene nanoparticles and the flame retardant TBBPA together, the chemical pollutant dominated the toxic response, causing oxidative stress, DNA damage, and disruption of mitochondrial function. The study shows that mixing microplastics with other contaminants can produce complex, hard-to-predict health effects in gut cells, which matters because people are routinely exposed to multiple pollutants at once.
Toxic effects of polystyrene microplastics on atrazine in zebrafish: Exogenous toxicity and endogenous mechanism
Researchers found that combining polystyrene microplastics with the common herbicide atrazine was more toxic to zebrafish than either pollutant alone, causing greater liver and gut damage. The combination also degraded water quality by reducing oxygen levels and increasing harmful nitrogen compounds. This is important because microplastics and pesticides frequently co-exist in the environment, meaning their combined effects on aquatic life and food safety may be worse than studies of individual pollutants suggest.
Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis
Researchers investigated the individual and combined toxicity of microplastics and triphenyltin, an organotin compound, in common carp by examining effects along the gut-brain axis. The study found that co-exposure to microplastics and triphenyltin produced combined toxic effects on the gut microbiome and brain function, suggesting that microplastics may enhance the toxicity of other environmental pollutants through their ability to adsorb contaminants.
The Role of Synthetic Polymers in the Aquatic Environment and Its Implications in Danio Rerio as a Model Organism
Exposing zebrafish to polystyrene microplastics combined with silver nanoparticles caused significantly more oxidative damage, tissue injury in gills and intestines, and higher mortality than either contaminant alone. The study demonstrates that microplastics can act as carriers that enhance the toxicity of co-pollutants like silver nanoparticles, a combination effect that is highly relevant to understanding real-world aquatic contamination where multiple pollutants co-occur.