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Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
Summary
Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.
The toxicology of microplastics in combination with other pollutants has attracted widespread attention. In this study, zebrafish were exposed to 3 mg/L polystyrene microplastic, 0.2 mg/L phenanthrene, and a combination of both. Zebrafish microplastic uptake, phenanthrene accumulation, antioxidant-associated enzyme activity and related gene expression, immune-associated gene expression, and the gut microflora were measured after 12 and 24 days of exposure. Phenanthrene and microplastic accumulation increased with exposure time and was also greater in the combined exposure group than in the single exposure group. Combined analysis of antioxidant enzyme activity and immune and antioxidant-related genes shows that exposure alone causes oxidative stress in zebrafish, ultimately increasing immunity and the expression of oxidative stress genes, while combined exposure exacerbates these changes. Fusobacteria decreased and Proteobacteria and Bacteroidetes increased in the three exposure groups of gut microorganisms. Overall, our study demonstrates that microplastics enhance the toxicity of phenanthrene and that the two have a synergistic effect.