Papers

61,005 results
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Article Tier 2

Development of microdroplet calibration for the accurate quantification of particles by single-particle ICP-TOFMS

Researchers developed and validated a microdroplet calibration technique for single-particle ICP-TOFMS to improve accuracy and throughput in multi-elemental quantification of nanoparticles and microparticles in complex sample matrices, achieving single-digit attogram detection limits for many elements.

2024
Article Tier 2

Single-Particle ICP-TOFMS with Online Microdroplet Calibration: A Versatile Approach for Accurate Quantification of Nanoparticles, Submicron Particles, and Microplastics in Seawater

Online microdroplet calibration was used with single-particle ICP-TOFMS to overcome matrix effects and achieve accurate multi-element quantification in nanoparticle and microparticle samples, demonstrating a versatile approach for environmental and industrial nanoparticle analysis.

2023 Analytical Chemistry 18 citations
Article Tier 2

Fundamental studies on droplet throughput and the analysis of single cells using a downward-pointing ICP-time-of-flight mass spectrometer

This study explored the capabilities of a downwardly oriented inductively coupled plasma time-of-flight mass spectrometer (ICP-TOFMS) for analyzing individual droplets and single cells. The time-of-flight configuration enabled rapid multi-element detection within short transient signals, improving single-cell elemental analysis throughput.

2021 Journal of Analytical Atomic Spectrometry 15 citations
Article Tier 2

Determination of carbon in microplastics and single cells by total consumption microdroplet ICP-TOFMS

This study developed a total consumption microdroplet ICP-TOFMS method to determine carbon content in microplastics and single cells, overcoming size limitations of conventional nebulization methods. The approach enables more accurate elemental characterization of individual microplastic particles.

2023 Analytical and Bioanalytical Chemistry 20 citations
Article Tier 2

Direct Measurement of Microplastics by Carbon Detection via Single Particle ICP-TOFMS in Complex Aqueous Suspensions

Researchers developed a single particle ICP-TOFMS method for directly measuring microplastics in complex aqueous suspensions by detecting carbon, successfully differentiating microplastic carbon from natural particles and dissolved organic carbon in environmental samples.

2023 Environmental Science & Technology 42 citations
Article Tier 2

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

This review describes how time-resolved ICP-MS analysis has transformed the technique from bulk elemental analysis into a tool for characterizing individual nanoparticles and single cells, enabling detection and characterization of nanoplastics and other nano-objects in complex samples.

2022 Chemical Science 79 citations
Article Tier 2

Rapid Single Particle Atmospheric Solids Analysis Probe-Mass Spectrometry for Multimodal Analysis of Microplastics

Researchers developed an atmospheric solid analysis probe coupled to mass spectrometry for rapid chemical characterization of single microplastic particles, enabling polymer identification while remaining compatible with complementary imaging techniques for comprehensive microplastic analysis.

2022 Analytical Chemistry 25 citations
Article Tier 2

Extending theLinear Dynamic Range of Single ParticleICP-MS for the Quantification of Microplastics

Researchers extended the linear dynamic range of single-particle ICP-MS for microplastic quantification to enable detection across a wider concentration range with high throughput. The method improvements allow more accurate characterisation of MP particle number and size distributions in environmental and biological samples.

2025 Figshare
Article Tier 2

Multimethod Platform Based on Dynamic Image Analysis and spICP-MS for Number-Based Quantification of Microplastics

Researchers developed and validated a multimethod analytical platform combining dynamic image analysis and single-particle ICP-MS to reliably quantify the number concentration of small microplastics (1-10 µm), a size range that has been difficult to measure accurately with existing methods.

2025 Analytical Chemistry
Article Tier 2

Coupling single particle ICP-MS with field-flow fractionation for characterizing metal nanoparticles contained in nanoplastic colloids

A combination of field-flow fractionation and single-particle ICP-MS was used to characterize composite particles containing metal nanoparticles in a polymer matrix, simulating what happens when plastic particles age in the environment and accumulate metals. This analytical approach helps reveal the complex chemical nature of weathered microplastics.

2019 Environmental Science Nano 43 citations
Article Tier 2

MultimethodPlatform Based on Dynamic Image Analysisand spICP-MS for Number-Based Quantification of Microplastics

Researchers developed and validated a multimethod platform combining dynamic image analysis (DIA) and single-particle ICP-MS (spICP-MS) for reliably quantifying the number concentration of small microplastics (1-10 µm), identifying critical instrument parameters that affect measurement accuracy for each technique.

2025 Figshare
Article Tier 2

Detection and characterization of secondary micro- and nanoplastics after aging using single particle ICP-MS and OF2i

Researchers combined single-particle ICP-MS and optofluidic force induction Raman spectroscopy to detect and characterize secondary micro- and nanoplastics generated during aging of larger plastic fragments, demonstrating that the combined approach can analyze particles across a wide size range.

2025 Unipub UB Graz (Universität Graz)
Article Tier 2

Application of Single-Particle ICP-MS to Determine the Mass Distribution and Number Concentrations of Environmental Nanoparticles and Colloids

Researchers applied single-particle ICP-MS to characterize elemental composition and size distributions of nanoparticles, colloids, and their aggregates in environmental samples. The study demonstrates that spICP-MS can effectively analyze homoaggregation and heteroaggregation of natural and anthropogenic nanoparticles including plastic-associated metal contaminants.

2021 Environmental Science & Technology Letters 34 citations
Article Tier 2

Detection of microplastics using inductively coupled plasma-mass spectrometry (ICP-MS) operated in single-event mode

Researchers tested whether inductively coupled plasma-mass spectrometry (ICP-MS) operated in single-event mode could detect microplastics by identifying their trace metal signatures, offering a novel analytical approach. This method could complement existing optical techniques for detecting microplastics in complex environmental samples.

2019 Journal of Analytical Atomic Spectrometry 149 citations
Article Tier 2

Introducing “time-of-flight single particle investigator” (TOF-SPI): a tool for quantitative spICP-TOFMS data analysis

Researchers developed a new software tool called TOF-SPI for analyzing single-particle data from a mass spectrometry technique used to characterize tiny particles in environmental samples. The software provides accurate, high-throughput processing of particle composition data. The tool is designed to help scientists more efficiently identify and quantify nanoparticles and microplastics in complex samples.

2024 Journal of Analytical Atomic Spectrometry 20 citations
Article Tier 2

Catching particles by atomic spectrometry: Benefits and limitations of single particle - inductively coupled plasma mass spectrometry

This review evaluates single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS) as an analytical technique, highlighting its expanding capabilities for detecting, sizing, and quantifying metal-based nanoparticles and emerging applications in microplastic and carbon-based particle analysis.

2022 Spectrochimica Acta Part B Atomic Spectroscopy 31 citations
Article Tier 2

Extending the Linear Dynamic Range of Single Particle ICP-MS for the Quantification of Microplastics

Researchers developed an improved method using single particle inductively coupled plasma mass spectrometry to detect and measure microplastics across a wider size range than previously possible. By extending the linear dynamic range of the technique, they could more accurately size and count larger microplastic particles. The advancement addresses a key limitation in current microplastic analytical methods and could improve environmental monitoring.

2025 Analytical Chemistry 2 citations
Article Tier 2

Quantitative sizing of microplastics up to 20 µm using ICP-TOFMS

Researchers tested new ways to measure the size of individual microplastic particles using a specialized mass spectrometry technique (ICP-TOFMS). By modifying the sample introduction system, they extended the upper size limit for detection from 10 micrometers to 20 micrometers. The study demonstrates that instrument configuration significantly affects the ability to accurately size and count microplastic particles in liquid samples.

2024 Journal of Analytical Atomic Spectrometry 12 citations
Article Tier 2

Nanoplastic Labelling with Metal Probes: Analytical Strategies for Their Sensitive Detection and Quantification by ICP Mass Spectrometry

Researchers developed metal probe labelling strategies to enable sensitive detection and quantification of nanoplastics by ICP mass spectrometry, overcoming the challenge that nanoplastics are too small and carbon-rich for conventional analytical techniques to distinguish.

2021 Molecules 30 citations
Article Tier 2

A Novel Strategy for the Detection and Quantification of Nanoplastics by Single Particle Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

A new analytical method was developed to detect and count individual nanoplastic particles in drinking water and river water using gold nanoparticles as tags and single particle ICP-MS for detection. The method can detect nanoplastics as small as 135 nm at environmentally relevant concentrations, providing a sensitive new tool for tracking nanoplastic contamination.

2020 Analytical Chemistry 152 citations
Article Tier 2

ICP-MS-Based Characterization and Quantification of Nano- and Microstructures

Researchers developed ICP-MS-based methods for characterizing and quantifying both nano- and microstructures in environmental and biological samples, evaluating the capability of single-particle ICP-MS and bulk analysis to distinguish particle populations by size, elemental composition, and number concentration. The methodology demonstrated detection of particles down to the low nanometer size range in complex matrices.

2024 Nanomaterials 4 citations
Article Tier 2

Particle Size Measurement and Detection of Bound Proteins of Non-Porous/Mesoporous Silica Microspheres by Single-Particle Inductively Coupled Plasma Mass Spectrometry

Not relevant to microplastics — this study validates single-particle ICP-MS for measuring the size of silica microspheres and detecting iron-containing proteins bound to their surfaces, focused on analytical chemistry applications.

2024 Molecules 2 citations
Article Tier 2

Characterisation of microplastics and unicellular algae in seawater by targeting carbon via single particle and single cell ICP-MS

Researchers used single particle and single cell ICP-MS to characterize microplastics and microalgae simultaneously in seawater by targeting carbon signals, demonstrating the technique as a rapid and sensitive tool for distinguishing plastic particles from biological material.

2021 Analytica Chimica Acta 62 citations
Article Tier 2

Development of single-cell ICP-TOFMS to measure nanoplastics association with human cells

Researchers developed a new single-cell analytical technique using ICP-TOFMS to measure how nanoplastic particles associate with individual human cells. This method enables detection of nanoplastics at the single-cell level, offering a more precise way to study how these tiny plastic particles interact with human tissues. The approach addresses a critical gap in understanding nanoplastic exposure and uptake in biological systems.

2023 Environmental Science Nano 20 citations