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Development of single-cell ICP-TOFMS to measure nanoplastics association with human cells
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Researchers developed a new single-cell analytical technique using ICP-TOFMS to measure how nanoplastic particles associate with individual human cells. This method enables detection of nanoplastics at the single-cell level, offering a more precise way to study how these tiny plastic particles interact with human tissues. The approach addresses a critical gap in understanding nanoplastic exposure and uptake in biological systems.
Nanoplastics, solid polymer particles smaller than 1 μm, are suspected to be widely present in the environment, food and air, and may pose a potential threat to human health.
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Investigating the Cellular Uptake of Model Nanoplastics by Single-Cell ICP-MS
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Researchers developed gold-doped polyethylene and polyvinyl chloride nanoparticles as model nanoplastics and used single-cell ICP-MS to investigate their cellular uptake. The study demonstrated that this approach enables rapid, high-throughput detection of nanoplastic interactions with cells, providing a valuable tool for understanding how environmentally relevant nanoplastics behave at the cellular level.
Nanoplastics prepared with uniformly distributed metal-tags: a novel approach to quantify size distribution and particle number concentration of polydisperse nanoplastics by single particle ICP-MS
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Researchers developed a new method for creating nanoplastic test particles with embedded metal tags, allowing scientists to precisely measure the size and number of nanoplastics using single-particle mass spectrometry. The particles have realistic irregular shapes and varied sizes, unlike the uniform spheres typically used in lab studies. This tool will help researchers more accurately study how nanoplastics behave in environmental and health experiments.
Developing Single Particle Icp-ms as a Technique to Advance Microplastics Analysis Capabilities
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Scientists improved a specialized lab technique that can detect and precisely count tiny plastic particles as small as a few millionths of a meter—smaller than what most current methods can reliably measure. This matters because before we can understand how microplastics affect our health, researchers need trustworthy, standardized ways to detect and measure them in things like water, food, or even human tissue, and this study is a step toward making those measurements more accurate and comparable across labs.
Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development
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This review covers methods for detecting and quantifying nanoplastics in environmental samples, highlighting the significant analytical challenges posed by their small size. Techniques including pyrolysis-GC/MS and single-particle ICP-MS are discussed as promising approaches.
Morphological and chemical characterization of nanoplastics in human tissue
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Researchers developed methods to visualize and chemically characterize nanoplastics that have accumulated in human tissue samples. They were able to identify plastic particles smaller than one micrometer within tissue using advanced microscopy and spectroscopy techniques. The study provides some of the first direct evidence of nanoscale plastic accumulation in the human body, which is essential for designing future health effects research.
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