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61,005 resultsShowing papers similar to Evaluation of Hematotoxicity in Female Wistar Rats Following Sub-Acute Inhalation Exposure to Polyethylene Microplastic
ClearHemotoxic effects of polyethylene microplastics on mice
Researchers exposed mice to different concentrations of polyethylene microplastics for 15 days and studied the effects on their blood. The highest dose caused significant damage to red blood cells, leading to abnormal shapes and reduced blood cell counts, along with impaired liver and kidney function. The study suggests that microplastic exposure may have harmful effects on blood health in mammals, including patterns consistent with anemia.
Subacute PVC Microplastic Inhalation Alters the Complete Blood Count Profile
Researchers exposed mice to PVC microplastics via inhalation over a subacute period and measured changes in complete blood count parameters. Inhalation caused significant alterations in blood cell profiles, indicating that inhaled PVC microplastics provoke a systemic hematological response.
Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links
Researchers gave male rats different doses of polyethylene microplastics orally for 35 days and found significant damage to blood cells and the blood-forming system. Higher doses caused oxidative stress, DNA damage, and changes in gene expression patterns related to blood cell production. The study suggests that chronic microplastic ingestion could harm the blood system through both genetic and epigenetic pathways.
Pengaruh Mikroplastik Polyethylene Terephthalate (PET) Terhadap Profil Eritrosit Tikus Betina Galur Wistar
This animal study tested how PET microplastics (common in plastic bottles) affect blood cells in rats. Results showed that exposure to PET microplastics may lower red blood cell counts, hemoglobin, and hematocrit levels, suggesting potential effects on blood health that warrant further investigation in humans.
Sub-acute polyethylene microplastic inhalation exposure induced pulmonary toxicity in wistar rats through inflammation and oxidative stress
Researchers exposed rats to airborne polyethylene microplastics through inhalation for 28 days and found significant signs of lung damage. The exposed animals showed increased inflammation markers, elevated oxidative stress, and tissue changes in the lungs compared to controls. The study provides evidence that breathing in microplastic particles from degraded plastic bags and bottles may cause pulmonary toxicity.
Dampak Pemberian Mikroplastik Poliethilen Peroral Terhadap Hitung Jenis Sel Leukosit Darah Rattus Norvegicus Strain Wistar
Researchers investigated the effects of oral polyethylene microplastic exposure on leukocyte differential counts in Wistar rat (Rattus norvegicus) blood, administering daily doses of 0.0375, 0.075, 0.15, and 0.6 mg microplastic particles by oral gavage to 30 rats divided into five groups. The study examined whether ingested microplastics crossing intestinal villi into the bloodstream triggered chronic inflammatory responses reflected in white blood cell composition.
Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)
Researchers fed albino rats different concentrations of microplastics for 28 days and measured changes in blood, liver, kidney, and lipid profiles. They found dose-dependent effects including reduced immune cell counts suggesting immunosuppression, lower red blood cell levels indicating anemia, and altered liver and kidney function markers. The study provides evidence that microplastic ingestion may affect multiple organ systems and blood health in a way that worsens with higher exposure levels.
Exploring Hematologic Effects of Microplastics: Urinary Mono-n-butyl Phthalate and Blood Cell Counts
This study investigated whether urinary mono-n-butyl phthalate (MBP), a biomarker of phthalate exposure and indirect indicator of microplastic exposure, is associated with hematologic effects in humans. Elevated MBP levels were linked to changes in blood cell counts and coagulation markers, suggesting microplastic-associated phthalate exposure may affect hematopoietic function.
Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice
Researchers studied the effects of polystyrene microplastics on the blood system and bone marrow gene expression in mice. They found that higher doses significantly decreased white blood cell counts and altered gene expression patterns in bone marrow cells, suggesting that microplastic exposure may affect the hematological system in mammals through changes in immune-related gene regulation.
In vivo test of acute exposure of polyethylene microplastics on kidney and liver of Rattus norvegicus Wistar strain rats
Researchers exposed male rats to a single dose of polyethylene microplastics and monitored them for 14 days, finding significant changes in body weight, elevated markers of kidney and liver stress in blood tests, and visible tissue abnormalities under microscopy. The results indicate that even short-term, high-dose microplastic exposure can cause measurable organ damage in mammals.
The Effect of Peroral Polyvinyl Chloride Microplastic on the Value of Prothrombin Time and Activated Partial Thromboplastin Time in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats given 0.5 mg/day of PVC microplastics orally exhibited altered prothrombin time and activated partial thromboplastin time values compared to controls, suggesting that microplastic accumulation in the liver impairs hepatocyte synthesis of blood clotting factors.
Effects of Microplastics on Cell Viability, Phagocytic Activity and Oxidative Stress in Human Peripheral Blood Mononuclear Cells
Researchers exposed human peripheral blood mononuclear cells (PBMCs) to four concentrations of polyethylene glycol and natural microplastics and measured cell viability, phagocytic activity, and oxidative stress. Higher microplastic concentrations reduced cell viability and phagocytic function while increasing oxidative stress markers, indicating that microplastics impair immune cell performance.
Exploring the Impacts of Polyethylene Microplastics on Rat Liver
Wistar rats exposed to polyethylene microplastics at 0.1–5 mg/kg for 4 weeks showed dose-dependent PE accumulation in liver tissue confirmed by fluorescence microscopy, with histopathological signs of liver injury despite no significant change in body weight.
Studi Toksikologi Lingkungan: Pengaruh Paparan Mikroplastik Terhadap Jumlah Leukosit Tikus Putih (Rattus norvegicus)
Researchers exposed white rats to varying doses of microplastics and found that all treated groups showed elevated white blood cell counts above normal ranges, indicating an inflammatory and immune stress response. The study suggests that microplastic ingestion triggers measurable immune system changes, with leukocyte counts serving as an early indicator of microplastic-related toxicity.
A review of the toxic effects of microplastics based on studies on mammals and mammalian cell lines
This review examined studies on the toxic effects of microplastics using mammals and mammalian cell experiments. Researchers found that adverse effects in animal studies appeared at relatively low daily doses of polystyrene and polyethylene microplastics. The study notes that cell-based experiments yielded variable results depending on the cell type tested, highlighting the complexity of understanding microplastic health impacts.
Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system
This review examines how airborne microplastics and nanoplastics affect human cells after being inhaled into the lungs. Because these particles are tiny and lightweight, they can penetrate deep into lung tissue and potentially enter the bloodstream. Studies on human cell lines show that inhaled plastic particles can cause inflammation, oxidative stress, and DNA damage, raising concerns about long-term respiratory and systemic health effects.
Impact of dietary exposure to polyester microfibers on hematology, serology and histology in a mouse model
Researchers fed albino mice varying doses of polyester microfibers for 35 days and measured the health effects. They found dose-dependent decreases in red blood cells, hemoglobin, and platelets, along with elevated liver enzymes and histopathological changes in the liver and gastrointestinal tract at higher doses. The study suggests that dietary exposure to polyester microfibers can cause significant hematological and organ-level effects in mammals.
Haematological and Histological Effects of Nanoplastics Released from Nonfood-grade Nonwoven Polyethene Bags on Mice
This study investigated the hematological and histological effects on mice of nanoplastics released from nonfood-grade nonwoven polyethylene bags commonly used for microwave cooking or carrying hot foods. Exposure to nanoplastics from these bags caused measurable changes in blood cell counts and tissue histopathology, raising safety concerns about the use of such bags in contact with hot food.
Detrimental effects of micro- and nanoplastics (MNPs) on platelet and neutrophil immunity: Recent findings and emerging insights
Researchers reviewed how micro- and nanoplastics (MNPs) harm the immune system, finding that tiny plastic particles can trigger dangerous inflammation in platelets and neutrophils — immune cells that control clotting and infection defense. These effects could disrupt normal blood vessel function and immune balance, though the exact mechanisms by which cells take up MNPs remain poorly understood.
Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats
Researchers gave adult male rats a single oral dose of microplastics made from PET water bottles and found that even this one-time exposure altered markers of liver, heart, and kidney function. Higher doses also reduced food intake and increased signs of oxidative stress, which is cell damage caused by harmful molecules. This study suggests that even brief microplastic exposure could trigger early changes in organ function, raising questions about the cumulative effect of daily human exposure through food and water.
Internalization of nano- and micro-plastics in human erythrocytes leads to oxidative stress and estrogen receptor-mediated cellular responses.
This study exposed human red blood cells to nano- and micro-plastics of different polymer types and found that both caused oxidative stress, membrane damage, and altered cell morphology. The findings suggest that plastic particles reaching the bloodstream could impair red blood cell function, with potential cardiovascular and systemic health consequences.
Dose‐Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
Researchers fed rats PVC and polystyrene microplastics at different doses for eight weeks and observed significant changes including weight loss, elevated blood glucose, increased cholesterol and liver enzymes, and signs of oxidative stress. The study suggests that oral microplastic exposure at these levels can cause dose-dependent toxicological effects across multiple organ systems in mammals.
Evaluation of potential toxicity of polyethylene microplastics on human derived cell lines
Researchers tested the toxic effects of two sizes of polyethylene microplastics on human cell lines representing different tissue types. They found that microplastic exposure triggered inflammatory responses and caused cellular damage, with effects varying depending on particle size and cell type. The findings suggest that microplastics commonly encountered in everyday life could pose health risks when they interact with human tissues.
Acute and subacute repeated oral toxicity study of fragmented microplastics in Sprague-Dawley rats
Researchers conducted acute and subacute oral toxicity studies of weathered polypropylene microplastics in rats, using realistic fragmented particles to assess health effects from dietary microplastic exposure, providing toxicological data relevant to human food safety.