We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Studi Toksikologi Lingkungan: Pengaruh Paparan Mikroplastik Terhadap Jumlah Leukosit Tikus Putih (Rattus norvegicus)
Summary
Researchers exposed white rats to varying doses of microplastics and found that all treated groups showed elevated white blood cell counts above normal ranges, indicating an inflammatory and immune stress response. The study suggests that microplastic ingestion triggers measurable immune system changes, with leukocyte counts serving as an early indicator of microplastic-related toxicity.
Increasing microplastic pollution in the environment raises concern about toxic risks to living organisms, and one important health risk involves immune system disruption, which can be observed through changes in leukocyte counts. This study aims to analyze the effect of microplastic exposure on leukocyte numbers in white rats (Rattus norvegicus) as an early indicator of environmental toxicity and health risk. The research also seeks to provide scientific evidence that can support environmental management policies and human health protection strategies. An experimental design was applied in which rats were divided into one control group and several treatment groups, and each treatment group received oral microplastic exposure at different doses over a specific period while FTIR spectroscopy (Fourier Transform Infrared Spectroscopy) was used to characterize the microplastic particles before administration. After the exposure period, blood samples were collected and leukocyte counts were measured using a hematology analyzer, and statistical analysis was then performed to compare leukocyte levels across all groups. The results showed that rats exposed to microplastics exhibited increased leukocyte counts above the normal range during both week one and week two, and these elevated counts were observed across groups that received different doses of microplastics. The rise in leukocyte numbers indicates an inflammatory response and immunological stress caused by microplastic exposure, and furthermore, the findings suggest that microplastics not only produce toxic effects but also tend to accumulate and remain in the body for extended periods. In conclusion, microplastic exposure has a significant effect on leukocyte counts in white rats, and this effect reflects immune system disturbance and potential disruption of immunological homeostasis. Consequently, microplastics should be recognized as an important threat in environmental toxicology, and continued research and regulatory attention are necessary to address the risks that microplastics pose to both ecological systems and human health
Sign in to start a discussion.
More Papers Like This
Dampak Pemberian Mikroplastik Poliethilen Peroral Terhadap Hitung Jenis Sel Leukosit Darah Rattus Norvegicus Strain Wistar
Researchers investigated the effects of oral polyethylene microplastic exposure on leukocyte differential counts in Wistar rat (Rattus norvegicus) blood, administering daily doses of 0.0375, 0.075, 0.15, and 0.6 mg microplastic particles by oral gavage to 30 rats divided into five groups. The study examined whether ingested microplastics crossing intestinal villi into the bloodstream triggered chronic inflammatory responses reflected in white blood cell composition.
Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)
Researchers fed albino rats different concentrations of microplastics for 28 days and measured changes in blood, liver, kidney, and lipid profiles. They found dose-dependent effects including reduced immune cell counts suggesting immunosuppression, lower red blood cell levels indicating anemia, and altered liver and kidney function markers. The study provides evidence that microplastic ingestion may affect multiple organ systems and blood health in a way that worsens with higher exposure levels.
Effect of Polystyrene Microplastics Exposure on Blood Parameters in Mice
Researchers exposed mice to polystyrene microplastics in drinking water over four weeks and found increased white blood cell counts, elevated liver enzymes indicating hepatic injury, and altered kidney function markers. The study suggests that subchronic oral microplastic exposure induces inflammatory responses and disrupts liver and kidney function, with no significant recovery observed after a two-week withdrawal period.
Pengaruh Mikroplastik Polyethylene Terephthalate (PET) Terhadap Profil Eritrosit Tikus Betina Galur Wistar
This animal study tested how PET microplastics (common in plastic bottles) affect blood cells in rats. Results showed that exposure to PET microplastics may lower red blood cell counts, hemoglobin, and hematocrit levels, suggesting potential effects on blood health that warrant further investigation in humans.
Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice
Researchers studied the effects of polystyrene microplastics on the blood system and bone marrow gene expression in mice. They found that higher doses significantly decreased white blood cell counts and altered gene expression patterns in bone marrow cells, suggesting that microplastic exposure may affect the hematological system in mammals through changes in immune-related gene regulation.