We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Subacute PVC Microplastic Inhalation Alters the Complete Blood Count Profile
AI summary Read the abstract
Researchers exposed mice to PVC microplastics via inhalation over a subacute period and measured changes in complete blood count parameters. Inhalation caused significant alterations in blood cell profiles, indicating that inhaled PVC microplastics provoke a systemic hematological response.
Plastics are used in a wide range of items worldwide. With the increased usage of plastics, concerns about environmental contamination and the body's exposure to plastics have increased. Microplastics have been found in the atmosphere, and breathing them in might cause a risk to our health. One plastic polymer type commonly used is Polyvinyl Chloride (PVC). However, the harmful consequences of inhaling PVC microplastics are not well known. This study aims to determine the effects of inhaling PVC microplastics on female Wistar rats' blood cells. We exposed PVC microplastics to female Wistar rats via the whole-body inhalation method for 28 days. At the end of the study, we analyzed morphology and completed blood count tests such as erythrocyte count, erythrocyte index, leukocyte count, leukocyte differential count, and thrombocyte count. We discovered that sub-acute exposure to PVC microplastics increases the number of erythrocytes and hemoglobin levels without causing morphology alteration. PVC microplastics groups showed leukopenia consistent with an increment of inflammatory marker neutrophil/ leukocyte ratio. PVC microplastic groups also showed a rise in thrombocyte counts. These results could provide data for understanding Microplastics inhalation's toxicity and health risks, especially in the blood.
More Papers Like This
Evaluation of Hematotoxicity in Female Wistar Rats Following Sub-Acute Inhalation Exposure to Polyethylene Microplastic
AI summary Read the abstract
Female Wistar rats were exposed to polyethylene microplastic aerosols at 15 mg per cubic meter for 4 hours daily over 28 days, and blood analysis revealed alterations in erythrocyte, leukocyte, and platelet counts. The findings suggest that sub-acute inhalation of polyethylene microplastics can cause hematotoxic effects.
Hemotoxic effects of polyethylene microplastics on mice
AI summary Read the abstract
Researchers exposed mice to different concentrations of polyethylene microplastics for 15 days and studied the effects on their blood. The highest dose caused significant damage to red blood cells, leading to abnormal shapes and reduced blood cell counts, along with impaired liver and kidney function. The study suggests that microplastic exposure may have harmful effects on blood health in mammals, including patterns consistent with anemia.
Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice
AI summary Read the abstract
Researchers studied the effects of polystyrene microplastics on the blood system and bone marrow gene expression in mice. They found that higher doses significantly decreased white blood cell counts and altered gene expression patterns in bone marrow cells, suggesting that microplastic exposure may affect the hematological system in mammals through changes in immune-related gene regulation.
In vivo toxicity assessment of microplastics in Balb/C mice : study of inhalation exposure and its inflammatory effects
AI summary Read the abstract
Researchers examined the in vivo toxicity of inhaled microplastics in Balb/C mice, studying pulmonary inflammation, oxidative stress, and systemic effects following repeated inhalation exposure. The study found dose-dependent lung inflammation and evidence of particle translocation to other organs.
Exploring Hematologic Effects of Microplastics: Urinary Mono-n-butyl Phthalate and Blood Cell Counts
AI summary Read the abstract
This study investigated whether urinary mono-n-butyl phthalate (MBP), a biomarker of phthalate exposure and indirect indicator of microplastic exposure, is associated with hematologic effects in humans. Elevated MBP levels were linked to changes in blood cell counts and coagulation markers, suggesting microplastic-associated phthalate exposure may affect hematopoietic function.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.