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Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links

Toxicology 2023 41 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Walaa Bayoumie El Gazzar, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Amina A. Farag Amina A. Farag Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Rania E. Sliem, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Rania E. Sliem, Heba S. Youssef, Rania E. Sliem, Rania E. Sliem, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Shaimaa E. Radwaan, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Walaa Bayoumie El Gazzar, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Walaa Bayoumie El Gazzar, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Heba S. Youssef, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Alaa El‐Din H. Sayed, Nashwa Nabil, Alaa El‐Din H. Sayed, Maha M. Mokhtar, Alaa El‐Din H. Sayed, Maha M. Mokhtar, Alaa El‐Din H. Sayed, Shaimaa E. Radwaan, Alaa El‐Din H. Sayed, Yasmin Marei, Amira M. Badr, Nesma S. Ismail, Nesma S. Ismail, Alaa El‐Din H. Sayed, Shaimaa E. Radwaan, Alaa El‐Din H. Sayed, Amira M. Badr, Alaa El‐Din H. Sayed, Rania E. Sliem, Rania E. Sliem, Alaa El‐Din H. Sayed, Amina A. Farag

Summary

Researchers gave male rats different doses of polyethylene microplastics orally for 35 days and found significant damage to blood cells and the blood-forming system. Higher doses caused oxidative stress, DNA damage, and changes in gene expression patterns related to blood cell production. The study suggests that chronic microplastic ingestion could harm the blood system through both genetic and epigenetic pathways.

Polymers

Body Systems

Hematopoietic

Models

Rat

Microplastics (MPs) pollution is a newly emerging environmental issue. MPs can accumulate within animals and humans, which can pose a serious health threat. Petroleum-based polyethylene (PE) is one of the most popular plastics. Accordingly, its exposure rates have steadily increased over the years. This study aimed to analyze the effects of PE-MPs on the hematological system of albino rats and the epigenetic effect. Five groups of adult male eight-weeks-old rats received either distilled water, corn oil, 3.75 mg/kg PE-MPs, 15 mg/kg PE-MPs, or 60 mg/kg of PE-MPs, daily by oral gavage for 35 days. PE-MPs significantly increased the body weights of the rats and lipid peroxidation, with concomitant reduction of superoxide dismutase activity and depletion of reduced glutathione, thus adversely affecting oxidants/antioxidants balance. Moreover, PE-MPs increased the % of abnormal RBCs, irregular cells, tear drop cells, Schistocyte cells, and folded cells. The genotoxic effects on DNA were evident by increased DNA damage, confirmed by the comet assay, in addition to increased DNA methylation. The effects of PE-MPs have been shown to be dose correlated. In conclusion, this study provides evidence of dose-related PE-MPs-induced hematological, genotoxic, and epigenetic effects in mammals, and thus emphasizes the potentially hazardous health effects of environmental PE-MPs.

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