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61,005 resultsShowing papers similar to Pengaruh Mikroplastik Polyethylene Terephthalate (PET) Terhadap Profil Eritrosit Tikus Betina Galur Wistar
ClearHemotoxic effects of polyethylene microplastics on mice
Researchers exposed mice to different concentrations of polyethylene microplastics for 15 days and studied the effects on their blood. The highest dose caused significant damage to red blood cells, leading to abnormal shapes and reduced blood cell counts, along with impaired liver and kidney function. The study suggests that microplastic exposure may have harmful effects on blood health in mammals, including patterns consistent with anemia.
Evaluation of Hematotoxicity in Female Wistar Rats Following Sub-Acute Inhalation Exposure to Polyethylene Microplastic
Female Wistar rats were exposed to polyethylene microplastic aerosols at 15 mg per cubic meter for 4 hours daily over 28 days, and blood analysis revealed alterations in erythrocyte, leukocyte, and platelet counts. The findings suggest that sub-acute inhalation of polyethylene microplastics can cause hematotoxic effects.
Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links
Researchers gave male rats different doses of polyethylene microplastics orally for 35 days and found significant damage to blood cells and the blood-forming system. Higher doses caused oxidative stress, DNA damage, and changes in gene expression patterns related to blood cell production. The study suggests that chronic microplastic ingestion could harm the blood system through both genetic and epigenetic pathways.
Do Microplastics have any significant effect on Red Blood Cells? An In-depth study by Systematic Review and Meta-Analysis
This meta-analysis pools data from multiple studies to examine how microplastics affect red blood cells. The findings highlight a knowledge gap about how microplastics interact with our blood cells, which is significant because red blood cells carry oxygen throughout the body and any disruption could affect overall health.
Studi Toksikologi Lingkungan: Pengaruh Paparan Mikroplastik Terhadap Jumlah Leukosit Tikus Putih (Rattus norvegicus)
Researchers exposed white rats to varying doses of microplastics and found that all treated groups showed elevated white blood cell counts above normal ranges, indicating an inflammatory and immune stress response. The study suggests that microplastic ingestion triggers measurable immune system changes, with leukocyte counts serving as an early indicator of microplastic-related toxicity.
Dampak Pemberian Mikroplastik Poliethilen Peroral Terhadap Hitung Jenis Sel Leukosit Darah Rattus Norvegicus Strain Wistar
Researchers investigated the effects of oral polyethylene microplastic exposure on leukocyte differential counts in Wistar rat (Rattus norvegicus) blood, administering daily doses of 0.0375, 0.075, 0.15, and 0.6 mg microplastic particles by oral gavage to 30 rats divided into five groups. The study examined whether ingested microplastics crossing intestinal villi into the bloodstream triggered chronic inflammatory responses reflected in white blood cell composition.
Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)
Researchers fed albino rats different concentrations of microplastics for 28 days and measured changes in blood, liver, kidney, and lipid profiles. They found dose-dependent effects including reduced immune cell counts suggesting immunosuppression, lower red blood cell levels indicating anemia, and altered liver and kidney function markers. The study provides evidence that microplastic ingestion may affect multiple organ systems and blood health in a way that worsens with higher exposure levels.
Exploring Hematologic Effects of Microplastics: Urinary Mono-n-butyl Phthalate and Blood Cell Counts
This study investigated whether urinary mono-n-butyl phthalate (MBP), a biomarker of phthalate exposure and indirect indicator of microplastic exposure, is associated with hematologic effects in humans. Elevated MBP levels were linked to changes in blood cell counts and coagulation markers, suggesting microplastic-associated phthalate exposure may affect hematopoietic function.
Evaluation of Lipid and Cardiovascular Parameters in Albino Rats Exposed to Polyethelene Teraphthalate
Albino rats exposed to polyethylene terephthalate (PET) microplastics showed altered lipid profiles and cardiovascular parameters, including changes in cholesterol and triglyceride levels, suggesting that PET microplastic exposure may contribute to cardiovascular disease risk.
Microplastic contamination of donated blood and red cell concentrates
Researchers investigated whether blood donation and processing procedures introduce microplastics into transfusion products, finding that plastic blood collection packs and processing steps may contribute to microplastic contamination. Microplastics have previously been found in human blood at varying concentrations, with potential associations to vascular and thrombotic effects. The study raises important questions about whether blood processing equipment may be an underrecognized source of microplastic exposure for transfusion recipients.
PET-microplastics trigger endothelial glycocalyx loss via ER stress and ROS unleashing IL-1β-driven SMC switching and early aortic structural impairment
Scientists found that tiny plastic particles from bottles and food packaging can damage blood vessels when consumed regularly. In lab rats, these microplastics caused harmful changes to the cells lining arteries, which could lead to heart disease over time. This research suggests that plastic pollution may pose a direct threat to our cardiovascular health, though more studies are needed to confirm the effects in humans.
Potential risk of aromatic microplastic fragments during urinary excretion
Researchers compared aromatic PET and alkyl polypropylene microplastics in human blood, finding that PET adsorbed roughly three times more proteins and red blood cells, then preferentially stuck to vascular and urinary epithelial cells, triggering oxidative stress and cell death markers — suggesting that brief transit through the body is not biologically harmless.
Improved multivariate quantification of plastic particles in human blood using non-targeted pyrolysis GC-MS
Scientists developed improved methods for measuring plastic particles in human blood, finding that standard techniques can produce significant errors, especially for PET plastic. The new multivariate approach reduced measurement errors by up to 38%, which is important because accurate blood measurements are essential for understanding how much microplastic exposure people actually face.
Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats
Researchers gave adult male rats a single oral dose of microplastics made from PET water bottles and found that even this one-time exposure altered markers of liver, heart, and kidney function. Higher doses also reduced food intake and increased signs of oxidative stress, which is cell damage caused by harmful molecules. This study suggests that even brief microplastic exposure could trigger early changes in organ function, raising questions about the cumulative effect of daily human exposure through food and water.
Potential Impact Microplastic Polyethylene Terephthalate on Mice
Researchers studied how polyethylene terephthalate (PET) microplastics affect mice when ingested, tracking where the particles end up in the body. They found that microplastics accumulated in various organs and caused measurable biological effects. The study adds to growing evidence that common plastic types found in food packaging may pose health risks when consumed.
Multispectroscopic Investigations of the Binding Interaction between Polyethylene Microplastics and Human Hemoglobin
Scientists used multiple spectroscopic techniques to investigate whether polyethylene microplastics can bind to human hemoglobin, the protein that carries oxygen in blood. They found that microplastic particles do interact with hemoglobin, altering its structural shape and potentially affecting its function. The findings raise questions about what might happen when microplastics enter the human bloodstream and interact with essential blood proteins.
Evaluation of Microplastic Content in Human Circulatory System and Its Potential Impacts on Systemic Health
Researchers detected microplastics in blood samples from 76% of 50 healthy adults using FTIR and Raman spectroscopy, with an average concentration of about 3 particles per milliliter. PET and polypropylene were the most common polymer types found, and the study discusses potential systemic health implications of circulating microplastics in the human body.
The Effect of Peroral Polyvinyl Chloride Microplastic on the Value of Prothrombin Time and Activated Partial Thromboplastin Time in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats given 0.5 mg/day of PVC microplastics orally exhibited altered prothrombin time and activated partial thromboplastin time values compared to controls, suggesting that microplastic accumulation in the liver impairs hepatocyte synthesis of blood clotting factors.
Effects of Microplastics on Cell Viability, Phagocytic Activity and Oxidative Stress in Human Peripheral Blood Mononuclear Cells
Researchers exposed human peripheral blood mononuclear cells (PBMCs) to four concentrations of polyethylene glycol and natural microplastics and measured cell viability, phagocytic activity, and oxidative stress. Higher microplastic concentrations reduced cell viability and phagocytic function while increasing oxidative stress markers, indicating that microplastics impair immune cell performance.
Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice
Researchers studied the effects of polystyrene microplastics on the blood system and bone marrow gene expression in mice. They found that higher doses significantly decreased white blood cell counts and altered gene expression patterns in bone marrow cells, suggesting that microplastic exposure may affect the hematological system in mammals through changes in immune-related gene regulation.
Renal and Hepatotoxic Effects of Polyethylene Terephthalate Microplastics in Chronically Exposed Albino Rats
Researchers exposed albino rats to different doses of PET microplastics for 90 days and measured kidney and liver function markers. They found that chronic exposure led to significant changes in serum urea, creatinine, and liver enzymes, suggesting potential kidney and liver damage at higher doses. The study also found that water stored in PET containers exposed to sunlight showed similar toxic effects, raising concerns about everyday plastic container use.
Influencia Ecotoxicológico de Microplásticos en el Perfil Hematológico de Vacunos Brown Swiss Fistulados
Researchers measured Bisphenol A (BPA) — a plastic-associated endocrine disruptor — in the blood of cattle that were exposed to microplastics through their environment. The study found detectable BPA levels that disrupted blood parameters, raising concerns about how microplastic-associated chemicals accumulate in livestock and potentially transfer to humans through meat and dairy.
Evaluating Cellular Effects of PET Microplastics in 2D/3D Models: Methodological Considerations of Reagent Interference
Researchers assessed the cellular effects of PET microplastics using both 2D and 3D cell culture models and found dose- and cell-type-dependent reductions in viability along with rapid generation of reactive oxygen species. The study highlights significant methodological challenges, as microplastics can interfere with common lab assays through light scattering, dye adsorption, and surface interactions, potentially producing misleading results without appropriate controls.
Microplastic particles in human blood and their association with coagulation markers
In a study of 36 healthy adults, microplastics were detected in the blood of 89% of participants, with polypropylene and polyethylene being the most common types found. Higher microplastic levels were associated with changes in blood clotting markers, suggesting that plastic particles in our bloodstream may affect how our blood coagulates, though larger studies are needed to confirm this link.