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61,005 resultsShowing papers similar to Combined effects of microplastics and copper on oxidative responses in zebrafish (Danio rerio)
ClearSingle and combined acute and subchronic toxic effects of microplastics and copper in zebrafish (Danio rerio) early life stages
Researchers exposed zebrafish embryos and larvae to microplastics, copper, and their combinations to assess individual and combined toxic effects. They found that microplastics alone caused limited harm, but when combined with copper, the mixture produced altered biochemical responses and changes in gene expression. The study suggests that microplastics can modify the toxicity of heavy metals in aquatic organisms during early development.
Long-term effects of individual and combined exposure to microplastics and copper in zebrafish hypothalamic-pituitary-gonadal axis – A multi-biomarker evaluation
This study exposed zebrafish to microplastics, copper, and both combined for 30 days and examined effects on their reproductive system. The combination of microplastics and copper caused greater hormonal disruption and oxidative stress than either pollutant alone, affecting genes that control reproduction in both male and female fish. These findings suggest that microplastics interacting with metal pollution in waterways could compound reproductive harm in aquatic organisms and potentially in humans who consume contaminated fish.
Toxicological effects induced on early life stages of zebrafish (Danio rerio) after an acute exposure to microplastics alone or co-exposed with copper
Researchers exposed zebrafish embryos to microplastics alone and combined with copper to assess their joint toxicity during early development. They found that copper, both alone and combined with microplastics, reduced survival, increased oxidative stress, inhibited a key nervous system enzyme, and disrupted avoidance and social behaviors. The study suggests that microplastics may modulate copper toxicity in some biological endpoints, highlighting the importance of studying combined pollutant exposures during vulnerable developmental stages.
Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)
Researchers examined the combined effects of polystyrene microplastics and copper on Nile tilapia and found that co-exposure increased copper accumulation in the liver and caused tissue damage in multiple organs. High concentrations of both contaminants together triggered oxidative stress, inflammation, and shifts in intestinal microbial communities. The study suggests that microplastics can worsen the toxic effects of heavy metals on freshwater fish.
Oxidative stress, apoptosis and serotonergic system changes in zebrafish (Danio rerio) gills after long-term exposure to microplastics and copper
Researchers exposed adult zebrafish to microplastics and copper for 30 days and examined the effects on their gill tissue. They found that the combination caused greater oxidative stress, increased cell death, and disrupted the serotonin signaling system in gills more than either pollutant alone. The study demonstrates that microplastics can amplify the toxic effects of heavy metals on fish respiratory organs.
Polystyrene microplastics (PS-MPs) harness copper presence and promote impairments in early zebrafish (Danio rerio) larvae: Developmental, biochemical, transcriptomic approaches and nontargeted metabolomics approaches
This zebrafish study found that polystyrene microplastics combined with copper produced worse toxic effects than either pollutant alone, causing developmental problems, oxidative stress, immune disruption, and nerve damage in larvae. The combination also disrupted the fish's metabolism in ways that neither pollutant caused independently. This is concerning because microplastics readily absorb heavy metals like copper in the environment, meaning organisms are often exposed to both together.
Biochemical impacts of PET microplastics and cadmium on Danio rerio under environmental conditions
This study examined the combined biochemical effects of PET microplastics and cadmium on zebrafish under environmentally relevant exposures, finding that co-exposure altered oxidative stress biomarkers, liver enzyme activity, and immune responses in ways that differed from single-contaminant exposures.
The impact of microplastics and copper on sex ratio and oxidative stress: analysis in zebrafish intestine, gonad and brain
Researchers exposed zebrafish embryos to copper, polyethylene, and polystyrene microplastics individually and in combination, finding that copper caused high mortality, PE alone induced a feminization trend, and co-exposure amplified adverse effects on sex differentiation and antioxidant enzyme activity.
Impact and Molecular Mechanism of Microplastics on Zebrafish in the Presence and Absence of Copper Nanoparticles
Polystyrene microplastics of three sizes combined with copper nanoparticles caused additive or synergistic toxicity in zebrafish, disrupting oxidative stress responses, gene expression, and early development, with 0.07-micrometer particles producing the most severe effects.
Toxic Effect of Combined Exposure of Microplastics and Copper on Goldfish (Carassius auratus): Insight from Oxidative Stress, Inflammation, Apoptosis and Autophagy in Hepatopancreas and Intestine
Researchers found that combined exposure to microplastics and copper in goldfish significantly enhanced copper accumulation and tissue damage in the hepatopancreas and intestine, triggering oxidative stress, inflammation, apoptosis, and autophagy beyond the effects of either pollutant alone.
Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.
Microplastics and copper effects on the neotropical teleost Prochilodus lineatus: Is there any interaction?
Researchers exposed the neotropical fish Prochilodus lineatus to polyethylene microplastics and copper separately and together, finding that microplastics alone caused oxidative stress and genotoxic effects, while combined exposure with copper did not consistently amplify harm compared to either stressor alone.
Co-exposure to microplastics and tire particles exacerbates oxidative stress and gut microbiome dysbiosis in zebrafish (Danio rerio)
Researchers exposed zebrafish for 21 days to environmentally relevant mixtures of microplastics and tire particles and found that combined exposure caused more severe oxidative stress and gut microbiome disruption than either pollutant alone. Particle accumulation occurred mainly in the gut with secondary deposition in the liver, and the most pronounced tissue damage was observed under the highest combined exposure. Gut microbiota analysis revealed significant shifts in community structure, including reduced beneficial bacteria and increased pollutant-tolerant species.
The Combined Effect of Copper Nanoparticles and Microplastics on Transcripts Involved in Oxidative Stress Pathway in Rainbow Trout (Oncorhynchus Mykiss) Hepatocytes
Primary rainbow trout hepatocytes were exposed to copper nanoparticles, microplastics, and their combination for 48 hours, finding that both dissolved copper and copper nanoparticles upregulated antioxidant enzyme transcripts while microplastics alone had minimal effect. Co-exposure to nanoparticles and microplastics did not significantly alter the oxidative stress response beyond nanoparticle effects alone.
Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics combined with cadmium for three weeks and found that the presence of microplastics significantly increased cadmium accumulation in the liver, gut, and gills. The combined exposure caused greater oxidative damage, tissue inflammation, and disruption of protective gene activity than either pollutant alone. The study demonstrates that microplastics can enhance the toxicity of heavy metals in fish by acting as carriers that increase the body's uptake of harmful substances.
Polyethylene microplastic exposure and concurrent effect with Aeromonas hydrophila infection on zebrafish
Researchers found that polyethylene microplastic exposure in zebrafish caused oxidative stress, altered antioxidant enzyme activity, and induced intestinal damage, with concurrent Aeromonas hydrophila infection amplifying these toxic effects and increasing mortality rates.
Microplastics and copper induce apoptosis, alter neurocircuits, and cause behavioral changes in zebrafish (Danio rerio) brain
Researchers investigated the chronic effects of microplastics and copper, alone and combined, on zebrafish brains over 30 days. The study found that both contaminants induced apoptosis, altered neurotransmitter pathways, and caused behavioral changes including increased anxiety, with combined exposure producing more severe effects than either pollutant alone.
Combined effects of microplastics and copper on antioxidant capacity, gut microbiome, and metabolomics of Pseudorasbora parva
Researchers studied the combined effects of microplastics and copper on the freshwater fish Pseudorasbora parva, examining antioxidant capacity, gut microbiota, and metabolic responses. They found that the presence of microplastics alongside copper actually reduced copper accumulation in tissues and lessened oxidative damage compared to copper exposure alone. The study suggests that while microplastics can alter the toxicity profile of metals in fish, the interactions are complex and involve metabolic adjustments that balance cellular repair and energy expenditure.
Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance
Researchers exposed adult zebrafish to polyethylene microplastics combined with a mixture of common water pollutants for 15 days and assessed DNA damage, mutation rates, and oxidative stress. They found that microplastics alone caused DNA damage and nuclear abnormalities as severe as those caused by the pollutant mixture, challenging the assumption that microplastics are less harmful than chemical contaminants. The study revealed that the fish's antioxidant defenses were overwhelmed across multiple organs, suggesting widespread oxidative damage from microplastic exposure.
Combined effects of polystyrene microplastics and cadmium on oxidative stress, apoptosis, and GH/IGF axis in zebrafish early life stages
Researchers exposed zebrafish embryos to polystyrene microplastics and cadmium, both alone and together, and found that the combination caused significantly worse effects than either pollutant individually. Co-exposure amplified oxidative stress, increased cell death in the spine and esophagus, and disrupted growth hormone pathways more severely than single exposures. The findings suggest that microplastics and heavy metals in waterways may interact to create heightened risks for developing fish.
Microplastics and Copper Affect Zebrafish Behavior and Responses to Predation Threat
Zebrafish were exposed to two size classes of aged polyethylene microplastics with and without copper (10 µg/L) to assess effects on behaviour and predator response. Microplastics and copper together impaired anti-predator behaviour more than either pollutant alone, suggesting synergistic impacts on fish survival in contaminated environments.
The Role of Synthetic Polymers in the Aquatic Environment and Its Implications in Danio Rerio as a Model Organism
Exposing zebrafish to polystyrene microplastics combined with silver nanoparticles caused significantly more oxidative damage, tissue injury in gills and intestines, and higher mortality than either contaminant alone. The study demonstrates that microplastics can act as carriers that enhance the toxicity of co-pollutants like silver nanoparticles, a combination effect that is highly relevant to understanding real-world aquatic contamination where multiple pollutants co-occur.
Toxicity of microplastics and copper, alone or combined, in blackspot seabream (Pagellus bogaraveo) larvae
Researchers examined the toxicity of microplastics and copper, alone and combined, on blackspot seabream larvae, finding that microplastic-copper mixtures can alter biochemical biomarkers and gene expression related to oxidative stress and immune response in developing fish.
The impact of combined exposure to triphenyltin and microplastics on the oxidative stress, energy metabolism, and digestive function of common carp (Cyprinus carpio)
Exposing common carp to triphenyltin and microplastics individually and in combination found that combined exposure caused greater oxidative stress, disrupted energy metabolism more severely, and more strongly impaired digestive enzyme activity than either pollutant alone.