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61,005 resultsShowing papers similar to Meta-analysis of H. pylori and the gut microbiome interactions and clinical outcomes
ClearRelationship Between Human Microbiome and Helicobacter pylori
This review explores the complex relationship between Helicobacter pylori, the bacterium that causes stomach ulcers, and the broader human gut microbiome. While not directly about microplastics, it provides important context because microplastic exposure is known to alter gut bacteria composition. Understanding how the gut microbiome interacts with specific pathogens is relevant to assessing whether microplastic-driven changes in gut bacteria could make people more vulnerable to infections.
Microplastic in Gastric Fasting Liquid and Associated Gastric Pathology
This study found microplastic particles in gastric fluid samples collected from patients undergoing routine stomach examinations, and noted associations between microplastic presence and gastric pathologies including H. pylori infection, intestinal metaplasia, and inflammation. The findings provide direct clinical evidence that microplastics accumulate in the human stomach and may be linked to gastric disease, though causality is not yet established. This is an important step toward understanding whether microplastic ingestion contributes to gastrointestinal health problems in humans.
Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
This Mendelian randomization study found genetic evidence supporting a causal relationship between specific gut microbiota compositions and gastrointestinal diseases. The findings suggest that microbiome-related interventions, including microbiome-dependent metabolites, could potentially be developed to treat or manage gastrointestinal conditions.
Quantitative evaluation of microplastic interference with gut microbiota: Identifying sensitive indicators and key factors
This meta-analysis combined with machine learning found that the Firmicutes-to-Bacteroidetes ratio is the most sensitive biomarker of microplastic-induced gut microbiome disruption, with exposure concentration, particle size, and duration as the key drivers. The resulting predictive model (R=0.91) offers a quantitative tool for assessing gastrointestinal harm from microplastic exposure.
Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics
This bibliometric analysis mapped global research trends and hotspots in gastrointestinal microbiome and toxicity studies, finding that modifications to the gut microbiome could offer new directions for treating and mitigating toxic exposures.
Polyethylene microplastics cooperate with Helicobacter pylori to promote gastric injury and inflammation in mice
Researchers investigated how polyethylene microplastics interact with the stomach bacterium Helicobacter pylori in mice. They found that H. pylori formed biofilms on microplastic surfaces, and that mice exposed to both microplastics and the bacteria developed more severe gastric inflammation than those exposed to either alone. The study suggests that microplastics may facilitate bacterial colonization in the stomach and amplify infection-related tissue damage.
The Footprint of Microbiome in Pediatric Asthma—A Complex Puzzle for a Balanced Development
This review examines the growing body of evidence linking the human microbiome to the development of pediatric asthma. Researchers found that the composition of bacteria in the gut and respiratory tract during early childhood appears to influence whether children develop asthma. The study suggests that understanding these microbial patterns could open new approaches for preventing or managing asthma in children.
Gut microbiota: an ideal biomarker and intervention strategy for aging
Not relevant to microplastics — this review explores how gut microbiome composition can serve as a biomarker for aging and a target for anti-aging interventions in humans, without addressing plastic pollution.
Preparation of Corn Peptides with Anti-Adhesive Activity and Its Functionality to Alleviate Gastric Injury Induced by Helicobacter pylori Infection In Vivo
This paper is not about microplastics; it investigates corn protein hydrolysates as potential anti-adhesive agents against Helicobacter pylori infection in the stomach, testing their anti-inflammatory and protective effects in cell and animal models.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
Gut Microbiota and Extraintestinal Disorders: Are They Interrelated?
This review examines how disturbances to the gut microbiome — the community of bacteria living in the digestive tract — are linked not just to intestinal diseases but also to allergies, asthma, and cardiovascular conditions. This context is relevant to microplastics research because ingested plastic particles have been shown to alter gut microbial communities.
The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?
This review examines the human archaeome—archaeal microorganisms inhabiting the gut, skin, and other body sites—and their potential roles in health and disease. It finds no conclusive archaeal pathogens in humans but identifies indirect roles through metabolic interactions with bacteria, relevant to gut microbiome research.
Unraveling Microplastic Effects on Gut Microbiota across Various Animals Using Machine Learning
This meta-analysis used machine learning to compare how microplastics affect gut bacteria across different animal species. Mice showed the strongest negative effects, including reduced gut bacterial diversity and imbalanced gut flora — shifts linked to health problems in humans too. The study identified specific bacterial markers, including Lactobacillus, that could help detect microplastic-related gut damage.
Deciphering the cytotoxicity of micro- and nanoplastics in Caco-2 cells through meta-analysis and machine learning
This meta-analysis uses data from multiple studies and machine learning to determine which properties of micro- and nanoplastics make them most toxic to human intestinal cells. The findings show that smaller particles and certain plastic types cause more cell damage, which is important for understanding how ingested microplastics may affect gut health.
Microplastics in our diet: complementary in vitro gut and epithelium models to understand their fate in the human digestive tract.
Researchers used complementary in vitro gut models to study how microplastics behave during human digestion, finding that digestive conditions alter microplastic surface properties and their interactions with gut cells. The work advances understanding of how ingested microplastics may affect the human digestive system.
[Effect of microand nanoplastics on the gastrointestinal mucosa and intestinal microbiome].
This review examines how micro- and nanoplastics entering through the food chain affect the gastrointestinal tract, finding evidence of disruption to gut mucosal integrity and intestinal microbiome composition, with implications for digestive health and systemic immune function.
Charge-dependent effects of nanoplastics on Helicobacter pylori virulence and gastric pathogenesis
Researchers infected mice with Helicobacter pylori and co-exposed them to positively charged, negatively charged, or neutral polystyrene nanoplastics, then assessed gastric pathogenesis. Positively charged nanoplastics most strongly enhanced H. pylori virulence, gastric inflammation, and ulceration, identifying surface charge as a key determinant of how nanoplastics interact with gut pathogens.
Clinical and diagnostic values of metagenomic next-generation sequencing for infection in hematology patients: a systematic review and meta-analysis
This meta-analysis of 22 studies found that metagenomic next-generation sequencing (mNGS) had a substantially higher pathogen detection rate than conventional microbiological tests in hematology patients, with pooled sensitivity of 87%. The mNGS results led to antibiotic adjustments in about 50% of cases, demonstrating its clinical value for diagnosing infections in immunocompromised patients.
Considering the Importance of Medicinal Plants and Natural Products and Their Mechanisms of Action for Treatment of Gastrointestinal Disorders
This bibliometric analysis of over a thousand articles reviewed medicinal plants and natural products for treating gastrointestinal disorders, highlighting their anti-inflammatory, antioxidant, and gut-protective mechanisms. While not focused on microplastics, the gut-protective properties of certain natural compounds are relevant to understanding how to mitigate gastrointestinal damage from environmental contaminants.
Exploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis
Researchers analyzed gut microbiome protein expression in Thai infants with atopic dermatitis using metaproteomic analysis. The study found reduced abundance of probiotic species and increased pathogenic bacteria and fungi in affected infants, along with stress-related protein expression patterns, suggesting that gut microbial imbalances and their functional interactions may play a role in this allergic skin condition.
Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
Researchers detected and characterized microplastics in human gastric cancer tissue and adjacent healthy tissue, finding significantly higher microplastic concentrations in cancer tissue, and used transcriptome sequencing to explore potential molecular mechanisms linking microplastic exposure to gastric cancer development.
Clinical and diagnostic values of metagenomic next-generation sequencing for infection in hematology patients: a systematic review and meta-analysis
Researchers conducted a systematic review and meta-analysis showing that metagenomic next-generation sequencing (mNGS) — a technology that identifies pathogens by reading their DNA — achieves high detection rates for infections in blood cancer patients. The findings suggest mNGS can guide antibiotic decisions and improve patient outcomes, particularly in China where the evidence base is strongest.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers investigated the combined effects of polystyrene nanoplastics and H. pylori bacteria on gastric cancer cells. In laboratory experiments, co-exposure reduced cancer cell viability, increased cell death, and enhanced autophagy. However, in animal models the combined exposure showed an antagonistic effect, where H. pylori actually reduced the metastasis-promoting effects of nanoplastics alone, suggesting complex interactions between nanoplastics and bacterial pathogens in the gut environment.
Exploring Bacterial Interactions with Microplastics in the Human Gut Microbiome
This review explored how microplastics interact with bacteria in the human gut microbiome, examining evidence that plastic particles can alter microbial community composition, enable colonization by pathogens, and facilitate horizontal gene transfer of antibiotic resistance genes. The gut microbiome appears to be a significant site of microplastic-microorganism interaction.