We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Meta-analysis of H. pylori and the gut microbiome interactions and clinical outcomes
Summary
This meta-analysis identified specific gut microbial signatures associated with H. pylori infection and disease progression, offering predictive models for early diagnosis and risk stratification. The findings support microbiome-based approaches to personalized treatment of H. pylori-associated gastrointestinal disorders.
This study highlights the critical role of GM dysbiosis in H. pylori-related disease progression. The identified microbial signatures and predictive models offer promising tools for early diagnosis, risk stratification, and personalized treatment of H. pylori-associated gastrointestinal disorders. Future integration of multi-omics data may further unravel the microbial mechanisms and support microbiome-based precision medicine.
Sign in to start a discussion.
More Papers Like This
Relationship Between Human Microbiome and Helicobacter pylori
This review explores the complex relationship between Helicobacter pylori, the bacterium that causes stomach ulcers, and the broader human gut microbiome. While not directly about microplastics, it provides important context because microplastic exposure is known to alter gut bacteria composition. Understanding how the gut microbiome interacts with specific pathogens is relevant to assessing whether microplastic-driven changes in gut bacteria could make people more vulnerable to infections.
Microplastic in Gastric Fasting Liquid and Associated Gastric Pathology
This study found microplastic particles in gastric fluid samples collected from patients undergoing routine stomach examinations, and noted associations between microplastic presence and gastric pathologies including H. pylori infection, intestinal metaplasia, and inflammation. The findings provide direct clinical evidence that microplastics accumulate in the human stomach and may be linked to gastric disease, though causality is not yet established. This is an important step toward understanding whether microplastic ingestion contributes to gastrointestinal health problems in humans.
Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
This Mendelian randomization study found genetic evidence supporting a causal relationship between specific gut microbiota compositions and gastrointestinal diseases. The findings suggest that microbiome-related interventions, including microbiome-dependent metabolites, could potentially be developed to treat or manage gastrointestinal conditions.
Quantitative evaluation of microplastic interference with gut microbiota: Identifying sensitive indicators and key factors
This meta-analysis combined with machine learning found that the Firmicutes-to-Bacteroidetes ratio is the most sensitive biomarker of microplastic-induced gut microbiome disruption, with exposure concentration, particle size, and duration as the key drivers. The resulting predictive model (R=0.91) offers a quantitative tool for assessing gastrointestinal harm from microplastic exposure.
Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics
This bibliometric analysis mapped global research trends and hotspots in gastrointestinal microbiome and toxicity studies, finding that modifications to the gut microbiome could offer new directions for treating and mitigating toxic exposures.