We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Gut microbiota: an ideal biomarker and intervention strategy for aging
Summary
Not relevant to microplastics — this review explores how gut microbiome composition can serve as a biomarker for aging and a target for anti-aging interventions in humans, without addressing plastic pollution.
Population aging is a substantial challenge for the global sanitation framework. Unhealthy aging tends to be accompanied by chronic diseases such as cardiovascular disease, diabetes, and cancer, which undermine the welfare of the elderly. Based on the fact that aging is inevitable but retarding aging is attainable, flexible aging characterization and efficient anti-aging become imperative for healthy aging. The gut microbiome, as the most dynamic component interacting with the organism, can affect the aging process through its own structure and metabolites, thus holding the potential to become both an ideal aging-related biomarker and an intervention strategy. This review summarizes the value of applying gut microbiota as aging-related microbial biomarkers in diagnosing aging state and monitoring the effect of anti-aging interventions, ultimately pointing to the future prospects of microbial intervention strategies in maintaining healthy aging.
Sign in to start a discussion.
More Papers Like This
Association between microplastics exposure and gut microbiota and metabolites in older adults: A cross-sectional study
Researchers analyzed fecal samples from 45 older adults to assess the relationship between microplastic exposure and gut microbiota. They found an average of 70 microplastic particles per gram of feces, primarily PVC, butadiene rubber, and polyethylene, and observed that microplastic exposure was associated with changes in gut microbial diversity and metabolite levels. The study suggests that microplastics may influence gut health in older adults by altering bacterial community composition and metabolic pathways.
Association of gut microbiota composition and function with a senescence-accelerated mouse model of Alzheimer’s Disease using 16S rRNA gene and metagenomic sequencing analysis
This study compared gut microbiota composition between a senescence-accelerated mouse model of Alzheimer's disease and normal aging mice, finding distinct differences in microbial communities and functional profiles. While not directly about microplastics, understanding gut microbiome disruption is relevant to research on how microplastic-associated chemical exposures may affect neurodegenerative disease risk.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
In vitro gut models reveal how microplastics interact with human microbiome in adults and infants.
Researchers used in vitro gut models to investigate how microplastics interact with the human gut microbiome in both adults and infants, finding differences in microbial community responses depending on life stage. The study provides mechanistic insights into how microplastic ingestion may differentially affect gut health across age groups.
Gut microbiota as an emerging target for the health implications of microplastics
This review examines how microplastic exposure disrupts the gut microbiome, finding evidence that microplastics damage intestinal barrier proteins, promote inflammation and oxidative stress, and may drive systemic effects including neurotoxicity and reproductive toxicity through gut-mediated pathways.