We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Di-(2-ethylhexyl) phthalate exacerbated the toxicity of polystyrene nanoplastics through histological damage and intestinal microbiota dysbiosis in freshwater Micropterus salmoides
ClearEffects of polystyrene nanoplastics on oxidative stress, histopathology and intestinal microbiota in largemouth bass (Micropterus salmoides)
Researchers exposed largemouth bass — a commercially important freshwater fish — to polystyrene nanoplastics (tiny plastic particles 100 nanometers in size) for up to 19 days, finding tissue damage in the gills, liver, and intestines along with elevated markers of cellular stress. While growth was not significantly affected, the fish adjusted their gut microbiome in response, suggesting nanoplastics trigger adaptive but potentially harmful physiological changes.
Trophic transfer of nanoplastics and di(2-ethylhexyl) phthalate in a freshwater food chain (Chlorella Pyrenoidosa-Daphnia magna-Micropterus salmoides) induced disturbance of lipid metabolism in fish
This study traced how nanoplastics and the common plasticizer chemical DEHP move through a freshwater food chain from algae to water fleas to fish. The nanoplastics accumulated at higher levels as they moved up the food chain, and the combined exposure caused liver damage and disrupted fat metabolism in the fish. Since humans eat fish at the top of food chains, this research shows how nanoplastics and their associated chemicals could build up through the food web and reach our plates.
Polystyrene nanoparticles aggravate the adverse effects of di-(2-ethylhexyl) phthalate on different segments of intestine in mice
Researchers exposed mice to polystyrene nanoparticles and the plasticizer DEHP simultaneously, finding that co-exposure caused greater intestinal damage — including shorter villi, disrupted tight junctions, and reduced mucus coverage — than either contaminant alone, with gut microbiota alterations likely contributing to the enhanced toxicity.
Single and Combined Effects of Polystyrene Nanoplastics and Dibutyl Phthalate on Hybrid Snakehead (Channa maculata ♀ × Channa argus ♂)
Researchers studied the individual and combined effects of polystyrene nanoplastics and the chemical plasticizer dibutyl phthalate on a commercially important freshwater fish. The nanoplastics alone inhibited growth and caused liver and intestinal damage, and co-exposure with the plasticizer made these effects worse. The findings suggest that microplastics and the chemicals they carry can have compounding harmful effects on aquatic organisms.
Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus)
Researchers exposed channel catfish to nanoplastics and bisphenol A, both alone and combined, and found the combination caused more severe liver and intestinal damage than either substance alone. The co-exposure also disrupted gut bacteria in ways that amplified toxicity. Since nanoplastics and BPA commonly co-exist in polluted water, their combined effects on aquatic organisms may be worse than what single-pollutant studies suggest.
Combined Enterohepatic Toxicity of Polystyrene Microplastics and Di(2-ethylhexyl) Phthalate in Mice: Gut Microbiota-Dependent Synergistic Effects
Researchers investigated the combined toxicity of polystyrene microplastics and the plasticizer DEHP in mice, focusing on gut-liver axis effects. They found that co-exposure worsened harmful outcomes compared to either pollutant alone, with gut microbiota playing a key mediating role in the synergistic toxicity. The study suggests that microplastics and their associated chemical additives may interact to amplify health risks through disruption of the gut-liver connection.
Toxic impacts of polystyrene nanoplastics and PCB77 in blunt snout bream: Evidence from tissue morphology, oxidative stress and intestinal microbiome
Researchers studied the combined toxicity of polystyrene nanoplastics and a persistent organic pollutant (PCB77) in freshwater fish. They found that co-exposure caused worse tissue damage, higher oxidative stress, and greater disruption to gut bacteria than either contaminant alone. The study highlights that microplastics can worsen the harmful effects of other environmental pollutants when organisms are exposed to both simultaneously.
Revealing the effects of polystyrene microplastics and di(2-ethylhexyl) phthalate on mussels:An evidence chain of gill-intestine-hemolymph
Researchers exposed mussels to polystyrene microplastics combined with the plasticizer DEHP for 30 days and found a cascade of harmful effects across gill, intestine, and blood systems. The combination caused gill damage, disrupted energy metabolism, triggered oxidative stress, altered gut microbiota, and suppressed immune function. The study establishes a pollutant cascade mechanism linking tissue damage, metabolic changes, and microbial imbalance in marine organisms.
Concurrent impacts of polystyrene nanoplastic exposure and Aeromonas hydrophila infection on oxidative stress, immune response and intestinal microbiota of grass carp (Ctenopharyngodon idella)
Researchers studied the combined effects of polystyrene nanoplastics and a bacterial infection on grass carp, a common freshwater fish. They found that nanoplastic exposure worsened the impact of the infection by increasing oxidative stress, suppressing immune responses, and disrupting the gut microbiome. The study suggests that nanoplastic pollution in waterways could make fish more vulnerable to disease by weakening their natural defenses.
The combined toxic effects of polyvinyl chloride microplastics and di(2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)
Researchers studied the combined toxic effects of PVC microplastics and the plasticizer DEHP on zebrafish embryos and larvae. While PVC alone slowed hatching and increased death rates, the combination of PVC and DEHP actually showed some antagonistic effects, reducing certain types of damage compared to individual exposures. The study provides insight into how microplastics and their associated chemicals may interact in complex ways when organisms are exposed to them together in natural waters.
Impact of polypropylene microplastics and chemical pollutants on European sea bass (Dicentrarchus labrax) gut microbiota and health
Researchers investigated how polypropylene microplastics, alone and combined with chemical pollutants, affect the gut health and microbiome of European sea bass. They found that microplastic ingestion altered the gut microbial community composition and that combined exposure with pollutants amplified the harmful effects. The study suggests that microplastics may serve as carriers for toxic chemicals, compounding their impact on fish health and potentially affecting seafood safety.
Polystyrene nano/microplastics induce microbiota dysbiosis, oxidative damage, and innate immune disruption in zebrafish
Researchers exposed zebrafish to polystyrene particles of two different sizes and found that both nano- and micro-sized plastics disrupted gut bacteria, caused oxidative damage, and altered immune responses. The severity of effects depended on particle size and concentration, with smaller particles and higher doses causing more harm. The study suggests that plastic particles in waterways may pose a broader threat to fish health than previously understood, affecting digestion, stress defenses, and immunity simultaneously.
Combined ecotoxicity of polystyrene microplastics and Di-(2-ethylhexyl) phthalate increase exposure risks to Mytilus coruscus based on the bioaccumulation, oxidative stress, metabolic profiles, and nutritional interferences
Researchers exposed hard-shelled mussels to a common plastic additive (DEHP) and polystyrene microplastics together, and found that the microplastics increased how much DEHP accumulated in the animals' digestive organs. The combined exposure disrupted the mussels' antioxidant defenses and altered their metabolic processes more than either pollutant alone. The study suggests that microplastics can amplify the harmful effects of chemical pollutants in marine organisms.
Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice
Researchers investigated the combined reproductive toxicity of polystyrene nanoparticles and the plasticizer DEHP in male mice over 35 days. The study found that co-exposure to nanoparticles and DEHP produced enhanced adverse effects on sperm quality and testicular tissue compared to either substance alone, suggesting nanoplastics may amplify the endocrine-disrupting effects of plasticizers.
Parental exposure to polystyrene nanoplastics and di(2-ethylhexyl) phthalate induces transgenerational growth and reproductive impairments through bioaccumulation in Daphnia magna
Researchers assessed the transgenerational impacts of parental exposure to polystyrene nanoplastics and the plasticizer DEHP on Daphnia magna over four generations. The study found that combined exposure to nanoplastics and DEHP caused growth and reproductive impairments that persisted across generations through bioaccumulation, suggesting that the ecological consequences of nanoplastic and plasticizer co-contamination may extend well beyond directly exposed organisms.
Exposure to Di(2‐Ethylhexyl) Phthalate Increases the Internalization of Polystyrene Microplastics by Human Hepatocellular Carcinoma Cells and Leads to Cell Damage
Researchers found that the common plasticizer DEHP significantly increased the uptake of polystyrene microplastics by human liver cancer cells in laboratory experiments. The smallest microplastic particles (100 nanometers) had the highest uptake rate, and DEHP exposure boosted internalization especially for the larger particles. The study raises concerns that co-exposure to plasticizers and microplastics, which commonly occur together in the environment, could amplify cellular damage beyond what either pollutant causes alone.
Polystyrene nanoplastics aggravated ecotoxicological effects of polychlorinated biphenyls in on zebrafish (Danio rerio) embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics combined with PCBs (polychlorinated biphenyls, banned industrial chemicals that persist in the environment) and found that nanoplastics significantly worsened PCB toxicity — amplifying damage to bone and heart development and suppressing the genes that normally help detoxify harmful chemicals. The nanoplastics also accumulated in the liver, intestine, and gills of zebrafish rather than being excreted, raising serious concerns about the ecological risks of rising nanoplastic levels in aquatic environments.
Polystyrene nanoplastics enhance the toxicological effects of DDE in zebrafish (Danio rerio) larvae
Researchers found that polystyrene nanoplastics enhanced the toxicity of the pesticide metabolite DDE in zebrafish larvae, with co-exposure causing greater developmental abnormalities and oxidative stress than either pollutant alone.
Integration of physiology, microbiota and metabolomics reveals toxic response of zebrafish gut to co-exposure to polystyrene nanoplastics and arsenic
Researchers exposed zebrafish to arsenic combined with polystyrene nanoplastics and found that the nanoplastics significantly increased arsenic accumulation in the gut, by up to 77% at the higher dose. The combined exposure caused more oxidative damage and greater disruption to gut bacteria and metabolism than arsenic alone. This study shows that nanoplastics can make other environmental pollutants more dangerous by helping them accumulate in the digestive system.
Toxic effects of polyethylene terephthalate microparticles and Di(2-ethylhexyl)phthalate on the calanoid copepod, Parvocalanus crassirostris
Researchers tested the toxic effects of polyethylene terephthalate microparticles and the plasticizer DEHP on aquatic organisms, finding that both caused harm individually and that combined exposure produced distinct toxic responses.
Interactive effects of polystyrene nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonates on the histomorphology, oxidative stress and gut microbiota in Hainan Medaka (Oryzias curvinotus)
Researchers exposed a freshwater fish species to nanoplastics and a fluorinated chemical pollutant, both alone and in combination, and found that the mixture caused more severe tissue damage than either substance alone. The combined exposure harmed gills, liver, and intestines while disrupting antioxidant systems and gut bacteria. The study suggests nanoplastics can worsen the effects of industrial chemicals on aquatic life.
Effect of polystyrene nanoplastics on the intestinal histopathology, oxidative stress, and microbiota of Acrossocheilus yunnanensis
Researchers studied the effects of polystyrene nanoplastics on the intestinal health of a freshwater fish species and found significant damage to the gut lining, including ruptured tissue and damaged nutrient-absorbing structures. The nanoplastics also increased oxidative stress markers and shifted the composition of gut bacteria, reducing beneficial species. The findings suggest that nanoplastic exposure can compromise both the physical barrier and microbial balance of fish intestines.
Enhanced toxicity of triphenyl phosphate to zebrafish in the presence of micro- and nano-plastics
Co-exposure of zebrafish to triphenyl phosphate (TPhP) with micro- or nano-polystyrene showed that nano-PS (46 nm) aggravated TPhP-induced liver and gonad enlargement, while micro-PS had minimal effect — suggesting nanoplastics can enhance the toxicity of organophosphate flame retardants.
Microplastic consumption elevates fish oxidative stress but does not affect predator-driven mortality
Juvenile coral reef fish exposed to polystyrene microplastics for just two days showed increased oxidative stress and cellular damage, especially when the plastics contained the common plasticizer DEHP. However, the microplastic exposure did not affect the fish's ability to escape predators in short-term trials. The study highlights that microplastics may cause hidden health damage to marine organisms even when they appear to function normally.