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The combined toxic effects of polyvinyl chloride microplastics and di(2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)

Journal of Hazardous Materials 2022 95 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Min Lv, Min Lv, Xizhen Zhao, Yunxia Ji, Xizhen Zhao, Yunxia Ji, Hongdan Wang, Yunxia Ji, Yunxia Ji, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Min Lv, Min Lv, Min Lv, Min Lv, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Qiaoning Wang, Yunxia Ji, Yunxia Ji, Qiaoning Wang, Xizhen Zhao, Xizhen Zhao, Yunqing Wang, Min Lv, Yunqing Wang, Xizhen Zhao, Lingxin Chen Xizhen Zhao, Min Lv, Min Lv, Min Lv, Yunxia Ji, Xizhen Zhao, Xizhen Zhao, Min Lv, Lingxin Chen Yunqing Wang, Lingxin Chen Xiaoyan Wang, Xizhen Zhao, Xizhen Zhao, Yunxia Ji, Lingxin Chen Yunqing Wang, Lingxin Chen Min Lv, Lingxin Chen Lingxin Chen Lingxin Chen Yunqing Wang, Xizhen Zhao, Qiaoning Wang, Yunqing Wang, Yunqing Wang, Lingxin Chen Yunxia Ji, Xizhen Zhao, Lingxin Chen Xiaoyan Wang, Qiaoning Wang, Xiaoyue Han, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Xiaoyan Wang, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Xiaoyue Han, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Min Lv, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Xiaoyan Wang, Lingxin Chen

Summary

Researchers studied the combined toxic effects of PVC microplastics and the plasticizer DEHP on zebrafish embryos and larvae. While PVC alone slowed hatching and increased death rates, the combination of PVC and DEHP actually showed some antagonistic effects, reducing certain types of damage compared to individual exposures. The study provides insight into how microplastics and their associated chemicals may interact in complex ways when organisms are exposed to them together in natural waters.

Polymers

PVC

Body Systems

Cardiovascular

Models

Zebrafish

Microplastics (MPs) have the characteristics of large specific surface area, high hydrophobicity and surface charge, so they are easy to combine with other pollutants and cause toxic effects on aquatic organisms. Here, we prepared a polyvinyl chloride-microplastics (PVC-MPs) fragmentation model to simulate the real microplastic state, and characterized its composition, morphology, particle size and zeta potential. On this basis, we used single and compound exposure of PVC and di(2-ethylhexyl) phthalate (DEHP) to explore their effects on hatchability and mortality of zebrafish (Danio rerio) embryos and toxicity to oxidative stress and cardiac development in zebrafish larvae. Herein, PVC-MPs slowed down the hatching rate of zebrafish embryos and induced the death of zebrafish, while DEHP could slow down the induced of death, it had no effect on hatching rate. The PVC-MPs/DEHP single pollution could induce the reactive oxygen species (ROS) and activated the antioxidant defense signaling pathway, while the compound group showed the level of feedback autoregulation of NF-E2-related factor 2 (Nrf2) signaling pathway. The single pollution also could inhibit the expression of genes related to cardiac development, while the combined pollution showed an antagonistic effect. This study provided a theoretical basis for the ecotoxicology and biomonitoring of MPs in the natural state.

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