Papers

61,005 results
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Article Tier 2

Nano-scale and micron-scale plastics amplify the bioaccumulation of benzophenone-3 and ciprofloxacin, as well as their co-exposure effect on disturbing the antioxidant defense system in mussels, Perna viridis

Researchers studied how nano- and micro-sized plastic particles affect the accumulation of benzophenone-3 and the antibiotic ciprofloxacin in green mussels. They found that smaller plastic particles enhanced the uptake of both chemicals into mussel tissues and caused greater disruption to the animals' antioxidant defense systems. The study demonstrates that plastic particle size matters when assessing how microplastics transport and amplify the effects of other environmental contaminants in marine organisms.

2024 Environmental Pollution 8 citations
Article Tier 2

Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota

Researchers exposed mussels to nanoplastics and the antibiotic norfloxacin, both alone and together, and found that the combination caused greater biochemical stress than either pollutant alone. Nanoplastics appeared to carry the antibiotic into mussel tissues, increasing its bioavailability and impact on gut microbiota. The findings suggest that nanoplastics can amplify the toxicity of other contaminants in marine organisms.

2023 The Science of The Total Environment 30 citations
Article Tier 2

The particle effect: comparative toxicity of chlorpyrifos in combination with microplastics and phytoplankton particles in mussel

Researchers compared how microplastics and natural phytoplankton particles each affect the toxicity of the pesticide chlorpyrifos in mussels. They found that both particle types adsorbed the pesticide and transferred it to the mussels, but the biological effects differed depending on the carrier. The study suggests that microplastics are not uniquely dangerous as pollutant carriers, since natural particles in the environment can play a similar role in shuttling chemicals into marine organisms.

2024 Aquatic Toxicology 7 citations
Article Tier 2

Influence of Particle Size on Ecotoxicity of Low-Density Polyethylene Microplastics, with and without Adsorbed Benzo-a-Pyrene, in Clam Scrobicularia plana

Researchers found that smaller polyethylene microplastics (4-6 µm) caused greater biomarker alterations in clam gills, while the digestive gland was more affected overall, suggesting particle size influences microplastic ecotoxicity in marine bivalves.

2022 Biomolecules 20 citations
Article Tier 2

Size-dependent adsorption of waterborne Benzophenone-3 on microplastics and its desorption under simulated gastrointestinal conditions

Researchers studied how the UV filter Benzophenone-3 adsorbs onto microplastics of different sizes and found that smaller particles bound more contaminant per unit mass; simulated gastrointestinal conditions caused significant desorption, suggesting microplastics could enhance chemical exposure in organisms that ingest them.

2021 Chemosphere 47 citations
Article Tier 2

Interaction of Environmental Pollutants with Microplastics: A Critical Review of Sorption Factors, Bioaccumulation and Ecotoxicological Effects

This critical review examines how microplastics interact with and enhance the toxicity of co-occurring environmental pollutants including heavy metals, persistent organic compounds, and pharmaceuticals, synthesizing evidence on sorption mechanisms and combined ecotoxicological effects.

2020 Toxics 313 citations
Article Tier 2

Effect of size continuum from nanoplastics to microplastics on marine mussel Mytilus edulis: Comparison in vitro/in vivo exposure scenarios

Researchers compared the effects of nanoplastics versus microplastics on marine mussels using both in vivo and in vitro approaches, finding that smaller plastic particles caused greater cellular and physiological impacts across the size continuum.

2022 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 33 citations
Article Tier 2

Ecotoxic effects of microplastics and contaminated microplastics – Emerging evidence and perspective

This review examined the ecotoxic effects of microplastics alone and when contaminated with other environmental pollutants. Researchers analyzed how microplastics' small size, surface properties, and hydrophobicity contribute to their environmental persistence and tendency to bind other contaminants. The study suggests that contaminated microplastics may pose greater ecological risks than pristine particles due to combined toxic effects.

2022 The Science of The Total Environment 45 citations
Article Tier 2

Interactive effects of micro/nanoplastics and nanomaterials/pharmaceuticals: Their ecotoxicological consequences in the aquatic systems

Researchers reviewed how micro- and nanoplastics interact with co-occurring nanomaterials and pharmaceuticals in aquatic environments, finding that plastics act as vectors that can either amplify or attenuate the bioavailability and toxicity of these contaminants depending on species, trophic level, and environmental conditions.

2021 Aquatic Toxicology 61 citations
Article Tier 2

Aged microplastics enhance their interaction with ciprofloxacin and joint toxicity on Escherichia coli

Researchers found that aged microplastics showed enhanced adsorption of the antibiotic ciprofloxacin compared to pristine particles, and that their combined exposure produced greater toxicity to E. coli at the molecular level than either pollutant alone.

2022 Ecotoxicology and Environmental Safety 39 citations
Article Tier 2

Toxicological interactions of microplastics/nanoplastics and environmental contaminants: Current knowledge and future perspectives

This review examines how the combined presence of micro- and nanoplastics with other environmental contaminants like heavy metals, pesticides, and pharmaceuticals affects toxicity. Researchers found that plastic particles can alter the bioavailability and toxic effects of co-occurring pollutants, sometimes increasing harm to organisms, which complicates environmental risk assessment.

2020 Journal of Hazardous Materials 501 citations
Article Tier 2

Impacts of size-fractionation on toxicity of marine microplastics: Enhanced integrated biomarker assessment in the tropical mussels, Perna viridis

Researchers studied how different sizes of polystyrene microplastics (0.5, 5, and 50 micrometers) affect toxicity in tropical green mussels. The study found that smaller microplastics caused greater bioaccumulation and more severe toxic effects, including oxidative stress and tissue damage, indicating that size is a critical factor in determining microplastic toxicity in marine organisms.

2022 The Science of The Total Environment 41 citations
Article Tier 2

Microplastics and associated emerging contaminants in the environment: Analysis, sorption mechanisms and effects of co-exposure

Researchers reviewed how microplastics act as carriers for other environmental pollutants — including antibiotics, PFAS, and triclosan — absorbing them from surrounding water and potentially delivering higher doses to organisms that ingest the plastic, with combined toxicity effects that can be either amplified or reduced depending on the combination.

2022 Trends in Environmental Analytical Chemistry 151 citations
Article Tier 2

A review on the combined toxicological effects of microplastics and their attached pollutants

Researchers reviewed how microplastics act as carriers for other environmental pollutants — including heavy metals and persistent organic chemicals — and how these combinations produce toxic effects in organisms that are more severe than either contaminant alone. The findings highlight a complex, layered toxicity problem that affects microbes, invertebrates, and vertebrates across marine and terrestrial environments.

2025 Emerging contaminants 20 citations
Article Tier 2

Microplastics as vectors for environmental contaminants in the food chain: Assessing the combined toxicological effects and bioavailability

This review examines how microplastics and nanoplastics act as carriers for environmental pollutants including heavy metals, organic chemicals, and microbial agents as they move through food chains. Researchers detail how polymer type, particle size, and environmental conditions influence the binding and release of these contaminants. The study highlights that the combined toxicity of microplastics together with the pollutants they carry may be greater than either would cause alone.

2025 Toxicology Letters 3 citations
Article Tier 2

Bioaccumulation of emerging contaminants in mussel (Mytilus galloprovincialis): Influence of microplastics

Researchers investigated whether microplastics influence the bioaccumulation of emerging contaminants in Mediterranean mussels. The study found that the presence of microplastics altered how certain chemical pollutants accumulated in mussel tissue, suggesting that microplastics can act as carriers that change the uptake and distribution of other contaminants in marine organisms.

2021 The Science of The Total Environment 76 citations
Article Tier 2

Biomarker responses of marine mussels (Mytilus galloprovincialis) experimentally exposed to emerging contaminants: pharmaceuticals and microplastics.

Researchers exposed marine mussels to the antibiotic clarithromycin, the antidepressant venlafaxine, and polystyrene microplastics alone and in combination, finding that the pharmaceuticals caused oxidative stress but that co-exposure with microplastics diminished these effects, likely because microplastics sequestered the drugs.

2026 Environmental science and pollution research international
Article Tier 2

Size-dependent effect of microplastics on toxicity and fate of diclofenac in two algae

This study investigated how different sizes of polystyrene microplastics affect two species of algae and interact with the common pharmaceutical pollutant diclofenac. Researchers found that the smallest microplastics caused the most significant growth inhibition in algae, and the combined presence of microplastics and diclofenac could alter how each pollutant behaves. The findings underscore how microplastics can change the toxicity and environmental fate of other water contaminants.

2023 Journal of Hazardous Materials 35 citations
Article Tier 2

Beyond carrier effects: Polyamide microplastics and TCPP jointly drive physiological toxicity in mussels at environmental concentrations

Researchers exposed thick-shelled mussels to polyamide microplastics combined with the flame retardant TCPP at environmentally relevant concentrations. They found that the combined stress caused physiological toxicity through an adsorption effect rather than a simple carrier effect, with potentially irreversible damage to digestive glands. The study also showed that the internal bacterial diversity of exposed mussels was altered, indicating broader ecological consequences of microplastic-chemical co-exposure in marine environments.

2025 Environmental Pollution 1 citations
Article Tier 2

A critical review on the interaction of polymer particles and co-existing contaminants: Adsorption mechanism, exposure factors, effects on plankton species

This review critically examines how microplastics and nanoplastics interact with co-existing contaminants including organic pollutants, toxic metals, and nanoparticles. Researchers found that the combined toxicity depends on multiple factors including plastic size, polymer type, weathering, and the nature of the co-contaminant. The study reveals that mixture effects on plankton species vary widely, with some combinations producing synergistic harm and others showing antagonistic interactions.

2022 Journal of Hazardous Materials 64 citations
Article Tier 2

Impact of microplastics pollution on ciprofloxacin bioaccumulation in the edible mussel (Perna viridis): Implications for human gut health risks

Researchers studied how microplastics affect the accumulation of the antibiotic ciprofloxacin in edible green mussels from a mariculture farm. They found that microplastics altered the way mussels absorbed and retained the antibiotic, with implications for human gut health when contaminated seafood is consumed. The study highlights the compounding food safety risks when multiple pollutants interact in aquaculture environments.

2024 Environmental Technology & Innovation 8 citations
Article Tier 2

Effects of heavy metals on the adsorption of ciprofloxacin on polyethylene microplastics: Mechanism and toxicity evaluation

Researchers studied how heavy metals in water affect the ability of polyethylene microplastics to absorb the antibiotic ciprofloxacin. They found that heavy metals competed with the antibiotic for binding sites on the microplastic surface, changing how much of each pollutant the plastic could carry. This is important because it shows microplastics in real-world environments may transport different combinations of pollutants, potentially delivering both antibiotics and heavy metals into the food chain.

2023 Chemosphere 83 citations
Article Tier 2

In-depth characterization revealed polymer type and chemical content specific effects of microplastic on Dreissena bugensis

Researchers exposed the freshwater mussel Dreissena bugensis to well-characterized microplastics of different polymer types and chemical compositions, finding that toxic effects varied by polymer type and additive content rather than particle size alone, highlighting the importance of chemical characterization in microplastic ecotoxicology studies.

2022 Journal of Hazardous Materials 36 citations
Article Tier 2

A Comparative Assessment of the Chronic Effects of Micro- and Nano-Plastics on the Physiology of the Mediterranean Mussel Mytilus galloprovincialis

Researchers compared the chronic effects of polystyrene microplastics and nanoplastics on Mediterranean mussels over a 21-day exposure at very low concentrations. They found that nanoplastics generally produced stronger biological responses than microplastics, including greater impacts on immune function, oxidative stress, and neurotoxicity markers. The study suggests that smaller plastic particles may pose greater risks to marine filter feeders even at trace environmental concentrations.

2021 Nanomaterials 89 citations