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Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota

The Science of The Total Environment 2023 30 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Youji Wang Youji Wang Menghong Hu, Ran Xu, Liang Li, Elvis Genbo Xu, Liang Li, Elvis Genbo Xu, Elvis Genbo Xu, Ran Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Chenglong Ji, Elvis Genbo Xu, Chenglong Ji, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Huifeng Wu, Liang Li, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Jiahui Zheng, Jiahui Zheng, Xiang Chen, Youji Wang Youji Wang Ran Xu, Menghong Hu, Youji Wang Elvis Genbo Xu, Youji Wang Liang Li, Yu‐Chuan Chen, Menghong Hu, Menghong Hu, Youji Wang Menghong Hu, Menghong Hu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Chenglong Ji, Chenglong Ji, Elvis Genbo Xu, Elvis Genbo Xu, Chenglong Ji, Elvis Genbo Xu, Huifeng Wu, Elvis Genbo Xu, Elvis Genbo Xu, Chenglong Ji, Elvis Genbo Xu, Elvis Genbo Xu, Chenglong Ji, Elvis Genbo Xu, Chenglong Ji, Elvis Genbo Xu, Elvis Genbo Xu, Chenglong Ji, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Liang Li, Xiang Chen, Huifeng Wu, Menghong Hu, Menghong Hu, Menghong Hu, Huifeng Wu, Huifeng Wu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Huifeng Wu, Youji Wang Elvis Genbo Xu, Huifeng Wu, Youji Wang Elvis Genbo Xu, Yu‐Chuan Chen, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Menghong Hu, Menghong Hu, Menghong Hu, Huifeng Wu, Huifeng Wu, Huifeng Wu, Huifeng Wu, Huifeng Wu, Huifeng Wu, Huifeng Wu, Menghong Hu, Menghong Hu, Huifeng Wu, Huifeng Wu, Menghong Hu, Huifeng Wu, Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Huifeng Wu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Menghong Hu, Menghong Hu, Menghong Hu, Elvis Genbo Xu, Elvis Genbo Xu, Huifeng Wu, Huifeng Wu, Menghong Hu, Huifeng Wu, Huifeng Wu, Yu‐Chuan Chen, Huifeng Wu, Xiang Chen, Xiang Chen, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Menghong Hu, Menghong Hu, Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Menghong Hu, Yu‐Chuan Chen, Youji Wang Elvis Genbo Xu, Youji Wang Menghong Hu, Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Chenglong Ji, Liang Li, Youji Wang Menghong Hu, Menghong Hu, Menghong Hu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Menghong Hu, Menghong Hu, Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Menghong Hu, Youji Wang Youji Wang Youji Wang Youji Wang Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Menghong Hu, Elvis Genbo Xu, Menghong Hu, Youji Wang Youji Wang Youji Wang Menghong Hu, Menghong Hu, Elvis Genbo Xu, Youji Wang Menghong Hu, Menghong Hu, Menghong Hu, Youji Wang Menghong Hu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Menghong Hu, Youji Wang Youji Wang Youji Wang

Summary

Researchers exposed mussels to nanoplastics and the antibiotic norfloxacin, both alone and together, and found that the combination caused greater biochemical stress than either pollutant alone. Nanoplastics appeared to carry the antibiotic into mussel tissues, increasing its bioavailability and impact on gut microbiota. The findings suggest that nanoplastics can amplify the toxicity of other contaminants in marine organisms.

Polymers

Models

Invertebrate other

Antibiotics and nanoplastics (NPs) are among the two most concerned and studied marine emerging contaminants in recent years. Given the large number of different types of antibiotics and NPs, there is a need to apply efficient tools to evaluate their combined toxic effects. Using the thick-shelled mussel (Mytilus coruscus) as a marine ecotoxicological model, we applied a battery of fast enzymatic activity assays and 16S rRNA sequencing to investigate the biochemical and gut microbial response of mussels exposed to antibiotic norfloxacin (NOR) and NPs (80 nm polystyrene beads) alone and in combination at environmentally relevant concentrations. After 15 days of exposure, NPs alone significantly inhibited superoxide dismutase (SOD) and amylase (AMS) activities, while catalase (CAT) was affected by both NOR and NPs. The changes in lysozyme (LZM) and lipase (LPS) were increased over time during the treatments. Co-exposure to NPs and NOR significantly affected glutathione (GSH) and trypsin (Typ), which might be explained by the increased bioavailable NOR carried by NPs. The richness and diversity of the gut microbiota of mussels were both decreased by exposures to NOR and NPs, and the top functions of gut microbiota that were affected by the exposures were predicted. The data fast generated by enzymatic test and 16S sequencing allowed further variance and correlation analysis to understand the plausible driving factors and toxicity mechanisms. Despite the toxic effects of only one type of antibiotics and NPs being evaluated, the validated assays on mussels are readily applicable to other antibiotics, NPs, and their mixture.

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