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A review on the combined toxicological effects of microplastics and their attached pollutants

Emerging contaminants 2025 20 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 63 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Mengzhen Li, Wenhao Ma, James Kar‐Hei Fang, Jiezhang Mo, Lei Li, Min Pan, Rong Li, Xiaoyun Zeng, Keng Po Lai

Summary

Researchers reviewed how microplastics act as carriers for other environmental pollutants — including heavy metals and persistent organic chemicals — and how these combinations produce toxic effects in organisms that are more severe than either contaminant alone. The findings highlight a complex, layered toxicity problem that affects microbes, invertebrates, and vertebrates across marine and terrestrial environments.

As an emerging environmental pollutant, microplastics (MPs) can adsorb various contaminants, including heavy metals and persistent organic pollutants (POPs). This ability stems from their small size and high specific surface area. Once adsorbed, the adherents can act in combination with MPs to produce synergistic toxic effects when they enter organisms through MPs, exacerbating their toxicity when introduced into organisms. This review examines the toxicological effects of the combination of different MPs and environmental pollutants on terrestrial and marine invertebrates, vertebrates, and microorganisms. In conclusion, the combined toxicological effects of MPs and their attachment to organisms are complex and multilayered. Existing studies have identified certain underlying mechanisms, underscoring the need for societies and governments to account for the combined toxic effects of MPs and their associated pollutants.

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