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61,005 resultsShowing papers similar to Toxicity and Accumulation of Nanoplastics Materials: A Review of Experimental Evidence Across Biological Systems
ClearAssessing the Impact of Nanoplastics in Biological Systems: Systematic Review of In Vitro Animal Studies
This systematic review of lab studies found that nanoplastics can damage cells in the gut, lungs, liver, brain, and reproductive organs of animals. These ultra-small plastic particles appear capable of crossing biological barriers and causing inflammation and oxidative stress, raising concerns about similar effects in humans.
Microplásticos y nanoplásticos: mecanismos de bioacumulación y toxicidad
This systematic review summarizes current scientific evidence on how micro- and nanoplastics interact with living systems. It found that these tiny particles can accumulate in biological tissues and trigger toxic responses, underscoring growing concerns about their potential effects on human health.
Nanoplastics in the Biological System: A Microscopic Menace with an Impact
This chapter examines nanoplastics, ultra-small polymer particles under one micrometer, as widespread environmental pollutants with significant biological consequences. The study reviews evidence from cellular and animal research indicating that nanoplastics can traverse biological barriers, move through air, water, and soil, and induce oxidative stress in living organisms, highlighting their unique mobility compared to larger microplastics.
Effect of Nanoplastics on Different Biological Systems
This review examines how nanoplastics affect multiple biological systems — including digestive, reproductive, nervous, and immune systems — synthesizing evidence that nanoplastics cross biological barriers and cause oxidative stress, inflammation, and physiological dysfunction across species.
A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health
This systematic review found growing evidence that micro- and nanoplastics accumulate in human tissues including lungs, gut, and blood, with lab studies showing potential disruption to immune, reproductive, endocrine, and nervous systems. The review identifies ingestion, inhalation, and dermal contact as the three main exposure routes and highlights that the smallest nanoplastic particles pose the greatest concern due to their ability to cross biological barriers.
Neurotoxicity of nanoplastics: A review
This review examines the growing body of evidence on how nanoplastics may affect the nervous system. Researchers summarized findings showing that nanoplastics can cross biological barriers, accumulate in brain tissue, and trigger oxidative stress and inflammation in nerve cells. The evidence indicates that nanoplastic exposure may contribute to neurotoxic effects, though more research is needed to fully understand the risks to human brain health.
Human and ecological health effects of nanoplastics: May not be a tiny problem
This review examined the health effects of nanoplastics in humans and ecosystems, finding that while direct human evidence is limited, nanoplastic particles cross biological barriers more readily than larger fragments and trigger oxidative stress, inflammation, and endocrine disruption in animal models, suggesting the problem is far from trivial.
Micro- and Nanoplastics on Human Health and Diseases: Perspectives and Recent Advances
This review provides a comprehensive overview of how micro- and nanoplastics enter the human body through ingestion, inhalation, and skin absorption, and how they can then travel through the bloodstream to reach virtually every organ. Researchers summarize evidence that these particles can trigger inflammation, oxidative stress, and disruption of hormonal and immune functions. The study emphasizes that the ability of these particles to cross biological barriers and accumulate in tissues makes understanding their long-term health effects an urgent research priority.
Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications
This review summarizes what is known about the toxicity of micro- and nanoplastics, noting they can cross critical barriers in the body including the blood-brain barrier. Studies in lab animals show these particles can cause DNA damage, oxidative stress, and cell death, with potential effects on the brain, heart, lungs, and skin, underscoring the need for more real-world human studies.
Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems
This review summarizes what researchers have learned about nanoplastic toxicity from studies in cell cultures, aquatic organisms, and terrestrial animals. Evidence indicates that nanoplastics can be internalized by cells through various mechanisms and their toxicity depends on factors like particle size, surface modifications, and concentration. The study identifies key knowledge gaps and recommends more systematic research to better understand the health risks these particles may pose to humans.
Assessing toxicological risk of nanoplastics contaminants in food and feed from ingestion pathway to human diseases
This review examines how nanoplastics, which are tiny fragments smaller than 0.1 micrometers, enter the human food chain and may pose health risks. Evidence indicates that nanoplastics can cross biological membranes more easily than larger microplastics, potentially reaching organs and accumulating over time. The study highlights the need for better detection methods and risk assessments to understand the long-term health implications of nanoplastic ingestion through food and beverages.
Why Detecting Nanoplastics in Humans Matters: Exposure Routes, Biological Evidence, and Potential Health Implications
This review summarizes current evidence on nanoplastic detection in human biological samples, including blood, lung tissue, placenta, and brain samples, confirming that human exposure involves internal uptake rather than just environmental contact. The study discusses how ingestion and inhalation are the dominant exposure pathways, while experimental research suggests nanoplastics may induce oxidative stress, inflammation, and endocrine disruption, though direct causal links in humans remain limited.
Micro- and nanoplastic induced cellular toxicity in mammals: A review
This review examines research on how micro- and nanoplastics cause cellular damage in mammalian systems, covering both laboratory and animal studies. Evidence indicates that these particles can trigger oxidative stress, inflammation, and DNA damage in cells, with smaller nanoplastics generally showing greater toxicity due to their ability to penetrate cell membranes more readily.
Human exposure to micro- and nanoplastic: biological effects and health consequence
This review summarized the biological effects and health consequences of human exposure to micro- and nanoplastics, covering routes of uptake (ingestion, inhalation, dermal), cellular toxicity mechanisms, and systemic health risks identified in recent experimental and epidemiological studies.
Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics.
Researchers found that after a single oral exposure in mice, nanoplastics were rapidly absorbed into the blood, accumulated in fat tissues, and crossed both the blood-brain and blood-testis barriers. The study demonstrated that the distribution and behavior of plastic particles in mammals is strongly dependent on particle size, with nanoplastics showing substantially greater tissue penetration than microplastics.
Systemic Accumulation and Distribution of Micro- and Nanoplastics in Human Tissues and Their Impact on Health: A Systematic Review
This systematic review synthesizes human evidence on the presence of micro- and nanoplastics in body tissues and fluids, including blood, lungs, placenta, breast milk, and liver. The research confirms that plastic particles can cross biological barriers and accumulate in multiple organ systems. While the long-term health effects are still being studied, the widespread presence of plastics inside the human body raises significant health concerns.
Penetration of micro/nanoplastics into biological barriers in organisms and associated health effects
This Chinese-language review systematically examined how micro- and nanoplastics penetrate gastrointestinal, respiratory, and skin barriers in humans and model organisms, and how they translocate via blood circulation to accumulate in organs including the liver, brain, testes, and placenta.
Nanoplastics in the Environment: Sources, Fate, Toxicity, Challenges and Mitigation Strategies
This review covers the formation, environmental fate, and health risks of nanoplastics, emphasizing their capacity to penetrate biological barriers and cause oxidative stress, inflammation, DNA damage, and endocrine disruption, alongside current strategies for mitigation.
Potential Health Impact of Environmentally Released Micro- and Nanoplastics in the Human Food Production Chain: Experiences from Nanotoxicology
This review assesses the potential for micro- and nanoplastics to enter the human food chain, drawing on evidence from studies of food production and related biological systems. Researchers found that while larger microplastics are unlikely to be absorbed by the human body, nanoplastics may be small enough to cross biological barriers and accumulate in tissues. The study highlights that much remains unknown about real-world human exposure levels and calls for more research into the health implications of these tiny particles in food.
Adverse Outcome Phenomena and Toxicity Mechanisms of Micro and Nanoplastics in Human Health
This review examines the growing evidence that micro- and nanoplastics can enter the human body through food, water, and air, and may contribute to harmful biological effects. Researchers found that these tiny particles can trigger oxidative stress, inflammation, and disruption of hormonal and immune systems in laboratory studies. The study highlights the need for a unified research approach to better understand how microplastic exposure may affect long-term human health.
A review on microplastics and nanoplastics in the environment: Their occurrence, exposure routes, toxic studies, and potential effects on human health
This review summarizes what is known about how microplastics and nanoplastics enter the human body through food, air, and skin contact, and what they do once inside. Studies on cells and animals show these tiny particles can cause oxidative stress, DNA damage, inflammation, and harm to the immune, digestive, reproductive, and nervous systems. The research makes clear that microplastics are not just an environmental problem but a direct concern for human health.
Effects of Nanoplastics on Human Health: A Comprehensive Study
This comprehensive review examines the diverse health effects of nanoplastics, drawing on toxicology, environmental science, and epidemiology to document how these particles interact with human biological systems. The authors conclude that nanoplastics represent a growing public health concern requiring further investigation.
The neurotoxic threat of micro- and nanoplastics: evidence from In Vitro and In Vivo models
This systematic review examined 26 studies showing that micro- and nanoplastics can cross into the brain, damage neurons, and trigger inflammation in lab and animal models. These findings raise concerns that long-term plastic exposure could contribute to neurological problems in humans, though more research is needed.
Toxicological considerations of nano-sized plastics
This review examined the toxicological considerations specific to nanoplastics, focusing on how particle deposition in different biological compartments, physical properties (size, shape, surface chemistry), and chemical additives interact to determine biological effects. The authors argue that understanding nanoplastic toxicology requires shifting focus from exposure characterization to mechanistic biological relevance at the tissue and organ level.