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61,005 resultsShowing papers similar to Evaluation of nanoplastics-induced redox imbalance in cells, larval zebrafish, and daphnia magna with a superoxide anion radical fluorescent probe
ClearImpact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective
Researchers showed that polystyrene nanoplastics accumulate in zebrafish larvae and trigger excessive reactive oxygen species production via NADPH oxidase upregulation, causing mitochondrial dysfunction, apoptosis, and NF-κB-driven inflammation — with inhibiting ROS generation effectively blocking downstream cell death and inflammatory responses.
Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment
This review examines how nano- and micro-sized plastic particles cause toxic effects in zebrafish, focusing on the link between oxidative stress and neurodevelopmental damage. Researchers found that plastic particle exposure disrupts the balance of reactive oxygen species in cells, which can impair brain development and nervous system function. The study suggests these oxidative stress responses may serve as early warning signals of plastic particle toxicity in aquatic organisms.
Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.
Polystyrene nanoplastic induces ROS production and affects the MAPK-HIF-1/NFkB-mediated antioxidant system in Daphnia pulex
Researchers exposed the freshwater crustacean Daphnia pulex to polystyrene nanoplastics and found dose-dependent overproduction of reactive oxygen species (ROS) alongside activation of the MAPK-HIF-1/NFkB stress-signaling cascade, revealing that epigenetic and oxidative pathways mediate nanoplastic toxicity in zooplankton.
Exposure to Nanoplastics Cause Caudal Vein Plexus Damage and Hematopoietic Dysfunction by Oxidative Stress Response in Zebrafish (Danio rerio)
Researchers found that nanoplastic exposure in zebrafish embryos caused damage to blood vessel development and impaired the formation of blood cells. The nanoplastics triggered oxidative stress in vascular and blood-forming cells, disrupting normal developmental processes. The study suggests that nanoplastic contamination in aquatic environments could affect early development in fish by interfering with their circulatory and blood cell production systems.
Nanoplastic Exposure Mediates Neurodevelopmental Toxicity by Activating the Oxidative Stress Response in Zebrafish (Danio rerio)
Exposure to 20-nanometer plastic particles caused developmental problems in zebrafish embryos, including shorter body length, heart defects, and lower survival rates. The nanoplastics specifically damaged the development of motor neurons and triggered oxidative stress, a harmful chemical imbalance in cells. These results suggest that very small plastic particles could interfere with early brain and nerve development.
Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure
Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.
Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance
Researchers exposed adult zebrafish to polyethylene microplastics combined with a mixture of common water pollutants for 15 days and assessed DNA damage, mutation rates, and oxidative stress. They found that microplastics alone caused DNA damage and nuclear abnormalities as severe as those caused by the pollutant mixture, challenging the assumption that microplastics are less harmful than chemical contaminants. The study revealed that the fish's antioxidant defenses were overwhelmed across multiple organs, suggesting widespread oxidative damage from microplastic exposure.
The Impact of Micro- and Nanoplastics on Aquatic Organisms: Mechanisms of Oxidative Stress and Implications for Human Health—A Review
This review examines how microplastics and nanoplastics cause oxidative stress, a harmful chemical imbalance, in aquatic organisms from plankton to fish. These tiny plastics accumulate in the food chain and may reach humans through seafood consumption. While the evidence of harm in aquatic species is growing, more research is needed to fully understand the implications for human health.
Genotoxic and Oxidative Damage of Environmental Pollutant Microplastics on Zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene and polyethylene microplastics at different concentrations for up to 21 days to measure oxidative stress and DNA damage. The study found that both types of microplastics disrupted the antioxidant system and caused measurable DNA damage, with effects depending on dosage and exposure time. These results suggest that microplastics in waterways could pose genetic and cellular risks to aquatic life.
Toxic effect of chronic exposure to polyethylene nano/microplastics on oxidative stress, neurotoxicity and gut microbiota of adult zebrafish (Danio rerio)
Researchers exposed adult zebrafish to polyethylene microplastics and nanoplastics for 21 days and found both caused oxidative damage to organs, disrupted brain function, and altered gut bacteria. Surprisingly, the toxic effects of microplastics and nanoplastics were similar in terms of brain and gut impacts, though organ-level oxidative damage varied by tissue type. These findings are concerning because they show that the plastic particles commonly found in food and water can simultaneously harm the brain, gut, and vital organs.
Superoxide Dismutase 3 Deficiency Disrupts the Regulation of Oxidative Stress Caused by Polystyrene Nanoplastics
Researchers used superoxide dismutase 3 (SOD3) knockout zebrafish to investigate the role of extracellular antioxidant defenses in polystyrene nanoplastic toxicity, finding that SOD3 deficiency worsened nanoplastic-induced oxidative stress, demonstrating that extracellular antioxidant capacity is an important determinant of nanoplastic harm.
Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways
This review maps the biological harm caused by micro- and nanoplastics to formal toxicity pathways, finding that oxidative stress is a common starting point for damage at every level from cells to whole organisms. Researchers found that in ecological settings, this oxidative damage cascades into growth inhibition and behavioral changes, while in human health contexts it may trigger inflammatory responses. The study highlights that more mammalian research is needed to fully define the health risks of plastic particle exposure.
Polyethylene microplastic exposure and concurrent effect with Aeromonas hydrophila infection on zebrafish
Researchers found that polyethylene microplastic exposure in zebrafish caused oxidative stress, altered antioxidant enzyme activity, and induced intestinal damage, with concurrent Aeromonas hydrophila infection amplifying these toxic effects and increasing mortality rates.
The mechanism of polystyrene nanoplastics hepatotoxicity in zebrafish (Danio rerio)
This study investigated the hepatotoxic mechanisms of polystyrene nanoplastics in zebrafish (Danio rerio), finding that nanoplastics accumulating in the liver triggered oxidative stress and cellular injury pathways. The results highlight nanoplastics as a significant liver toxicant in aquatic vertebrates.
Genotoxicity and Genomic Instability Induced by Micro- and Nanoplastics: A Comprehensive Multi-Taxa Mechanistic Review.
This review of existing research found that tiny plastic particles (microplastics and nanoplastics) can damage DNA in many different living things, from fish to human cells. The plastic particles cause this damage by creating harmful molecules called free radicals, disrupting the body's ability to repair DNA, and triggering inflammation. These findings suggest that the growing amount of plastic pollution in our environment could pose serious health risks to humans and wildlife.
Toxicological Research on Nano and Microplastics in Environmental Pollution: Current Advances and Future Directions
This review summarizes existing research on how nano- and microplastics from our massive global plastic production enter aquatic environments, absorb harmful chemicals, and move through food chains into living organisms. Studies show these particles can cause brain damage, disrupt metabolism, trigger inflammation, and produce harmful oxidative stress in aquatic species, with microplastics even detected in commercial fish that people eat.
Sodium nitroprusside alleviates nanoplastics-induced developmental toxicity by suppressing apoptosis, ferroptosis and inflammation
Researchers discovered that sodium nitroprusside, a compound that releases nitric oxide, could protect zebrafish larvae from the toxic effects of nanoplastics by reducing oxidative stress, cell death, and inflammation. The treatment worked by activating a signaling pathway that neutralized the harmful reactive oxygen species triggered by nanoplastic exposure. This is one of the first studies to identify a potential treatment that could counteract nanoplastic toxicity, offering hope for developing protective strategies against plastic particle exposure.
Toxic mechanisms of nanoplastics exposure at environmental concentrations on juvenile red swamp crayfish (Procambarus clarkii): From multiple perspectives
Researchers exposed juvenile red swamp crayfish to nanoplastics at concentrations found in the environment and observed stunted growth, oxidative stress, liver and gill damage, and changes in gene activity. Different concentrations triggered different toxic pathways, including immune disruption and metabolic problems. Since crayfish are a widely consumed freshwater species, these findings raise concerns about nanoplastic contamination in the food supply.
Immune response to polystyrene microplastics: Regulation of inflammatory response via the ROS-driven NF-κB pathway in zebrafish (Danio rerio)
Researchers found that polystyrene microplastics triggered immune system inflammation in zebrafish by generating reactive oxygen species (ROS) that activated the NF-kB signaling pathway. The microplastics accumulated mainly in the intestines, causing tissue damage and behavioral changes in the fish. This study identifies a specific molecular mechanism by which microplastics cause immune dysfunction, which could be relevant to understanding inflammation in humans exposed to microplastics.
Potential toxicity of nanoplastics to fish and aquatic invertebrates: Current understanding, mechanistic interpretation, and meta-analysis
Nanoplastics significantly reduced survival, behavior, and reproduction of fish and aquatic invertebrates by 56%, 24%, and 36% respectively, while increasing oxidative stress by 72% and decreasing antioxidant defenses by 24%, with effects influenced by particle size, functional groups, and concentration.
Study of the effects of nanoplastics ingestion in a freshwater fish ( Danio rerio )
Researchers exposed zebrafish to polystyrene nanoplastics and found evidence of intestinal damage, oxidative stress, and behavioral changes. The study adds to growing evidence that nanoplastics in freshwater environments can harm fish health, with potential implications for the health of ecosystems and fish-eating humans.
Toxic effects of naturally-aged microplastics on zebrafish juveniles: A more realistic approach to plastic pollution in freshwater ecosystems
Researchers exposed juvenile zebrafish to naturally aged polystyrene microplastics at environmentally relevant concentrations for five days. They found that the microplastics disrupted the fish's antioxidant defenses, indicating oxidative stress, and caused measurable cellular and neurological impacts. The study suggests that even short-term exposure to realistic levels of weathered microplastics can affect the health of freshwater organisms.
Microplastics Induce Structural Color Deterioration in Fish Poecilia reticulata Mediated by Oxidative Stress
Researchers exposed guppy fish to environmentally relevant concentrations of microplastics and nanoplastics, finding that 160 µg/L microplastics significantly reduced growth and impaired structural blue coloration by disrupting skin oxidative stress markers. Nanoplastics caused more severe gut lipid peroxidation, showing that plastic type matters for biological impact.