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61,005 resultsShowing papers similar to Adverse Outcome Phenomena and Toxicity Mechanisms of Micro and Nanoplastics in Human Health
ClearMicro- and Nanoplastics on Human Health and Diseases: Perspectives and Recent Advances
This review provides a comprehensive overview of how micro- and nanoplastics enter the human body through ingestion, inhalation, and skin absorption, and how they can then travel through the bloodstream to reach virtually every organ. Researchers summarize evidence that these particles can trigger inflammation, oxidative stress, and disruption of hormonal and immune functions. The study emphasizes that the ability of these particles to cross biological barriers and accumulate in tissues makes understanding their long-term health effects an urgent research priority.
A review on microplastics and nanoplastics in the environment: Their occurrence, exposure routes, toxic studies, and potential effects on human health
This review summarizes what is known about how microplastics and nanoplastics enter the human body through food, air, and skin contact, and what they do once inside. Studies on cells and animals show these tiny particles can cause oxidative stress, DNA damage, inflammation, and harm to the immune, digestive, reproductive, and nervous systems. The research makes clear that microplastics are not just an environmental problem but a direct concern for human health.
Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects
This review examines the biological mechanisms by which micro- and nanoplastics may cause harm in humans, including oxidative stress, inflammation, disruption of protective barriers, and immune system problems. Evidence from lab and animal studies suggests these particles can affect the gut, heart, brain, and reproductive systems, though human data is still limited to detecting plastics in tissues rather than proving they cause specific diseases. The authors highlight that most studies use higher doses than people actually encounter, making it important to develop research models that better reflect real-world chronic exposure.
From Environment to Body: Microplastics' Sources, Pathways, and Health Repercussions
This systematic review provides a comprehensive overview of how microplastics enter the human body through food, water, air, and skin contact. Researchers found evidence that these particles may cause physical damage, chemical toxicity, inflammation, and oxidative stress in biological systems. The study highlights significant gaps in understanding the long-term health implications of chronic microplastic exposure in humans.
Microplastics and Nanoplastics in Human Health: Toxicological Mechanisms Involving Oxidative Stress, Endocrine Interference, and Inflammatory Responses
Tiny plastic particles called microplastics and nanoplastics are now found everywhere—in our air, water, and food—and this review of existing research shows they may harm our health in three main ways. These particles can damage cells, disrupt hormones, and cause inflammation throughout the body, potentially affecting organs like the heart, liver, and brain. While scientists are still studying exactly how dangerous these plastic particles are to humans, the evidence suggests we should be concerned about our constant exposure to them.
The Impact of Microplastic on Human Health
This review synthesized evidence on microplastic exposure pathways and health effects in humans, finding that microplastics enter the body via ingestion, inhalation, and dermal contact and are associated with oxidative stress, inflammation, genotoxicity, and endocrine disruption.
Microplastics and Human Health: A Comprehensive Review on Exposure Pathways, Toxicity, and Emerging Risks
This comprehensive review examines microplastic exposure pathways in humans, methods of detection, and the potential toxic effects on various biological systems. The study highlights growing evidence that microplastics can enter the body through ingestion, inhalation, and dermal contact, and may affect multiple organ systems, though significant uncertainties remain about long-term health outcomes.
Environmental exposure to microplastics: An overview on possible human health effects
This review examines the potential health effects of human exposure to microplastics through ingestion, inhalation, and skin contact. Researchers found that microplastic exposure may cause oxidative stress, inflammation, and immune system disruption, with the body's inability to break down synthetic particles potentially leading to chronic inflammation. The study emphasizes that while evidence of harm is growing, microplastic toxicity varies greatly depending on particle properties, concentration, and individual susceptibility.
A Systematic Review on the Impact of Micro-Nanoplastics Exposure on Human Health and Diseases
This systematic review summarizes existing research on how micro and nanoplastic exposure affects human health and may contribute to disease. The evidence suggests that these tiny particles can enter the body through food, water, air, and even cosmetics, potentially causing inflammation, oxidative stress, and disruptions to the immune and reproductive systems.
Mechanistic insight into potential toxic effects of microplastics and nanoplastics on human health
This review summarizes how microplastics and nanoplastics enter the body through breathing, eating, and skin contact, then travel through the bloodstream to deposit in organs. Studies show they can cause oxidative stress, inflammation, immune dysfunction, genetic damage, developmental abnormalities, and potentially cancer, though most evidence comes from cell and animal studies rather than human research.
Unseen Hazards—Toxicological Effects and Human Health Impacts of Nanoplastics and Microplastics
This review covers the toxicological effects of microplastics and nanoplastics in humans, examining exposure routes (oral, inhalation, dermal), tissue distribution, and mechanisms of harm including oxidative stress, inflammation, and endocrine disruption. It emphasises the importance of particle size, polymer type, and adsorbed chemical additives in determining toxicity.
Microplastics and Nanoplastics in Health Concerning Cellular Toxicity Mechanisms, Exposure Pathways, and Global Mitigation Strategies
This review synthesizes current knowledge on how micro- and nanoplastics cause cellular damage in the human body, covering mechanisms like oxidative stress, inflammation, DNA damage, and disruption of cell signaling pathways. Researchers note that exposure occurs through multiple routes including ingestion and inhalation, allowing particles to reach organs throughout the body. The study highlights significant gaps in understanding long-term and low-dose exposure effects that are most relevant to everyday human contact with these particles.
Effects of Microplastics on Human Physiology: Mechanisms of Toxicity and Health Risks
This systematic review of 48 studies found that microplastics have been detected in human blood, placenta, and reproductive tissues, showing they can cross biological barriers. The most common harmful effects include oxidative stress, inflammation, hormonal disruption, and DNA damage, raising serious questions about long-term health consequences.
Microplastics and Nanoplastics in Human Health: Toxicological Mechanisms Involving Oxidative Stress, Endocrine Interference, and Inflammatory Responses
This review of existing research shows that tiny plastic particles from broken-down plastic waste can harm our bodies in three main ways: by damaging cells, disrupting hormones, and causing inflammation. These microscopic plastics are now everywhere in our environment - in the air we breathe, water we drink, and food we eat - and studies suggest they may contribute to health problems affecting our hearts, digestive system, and other organs. While scientists are still studying exactly how dangerous these particles are to humans, the evidence suggests we should be concerned about our constant exposure to plastic pollution.
Potential Health Impact of Microplastics: A Review of Environmental Distribution, Human Exposure, and Toxic Effects
This review summarizes existing research on how microplastics are found throughout the environment and in human samples, entering the body through food, air, and skin contact. Lab studies in cells and animals show microplastics can cause oxidative stress, DNA damage, immune reactions, brain toxicity, and reproductive harm, and early human health data links microplastic exposure to several chronic diseases.
Human exposure to microplastics: A review on exposure routes and public health impacts
This review examines how microplastics enter the human body through food, air, and skin contact and the health effects they can cause, including oxidative stress, inflammation, hormone disruption, and potential DNA damage. Despite growing evidence of harm, the exact routes plastics take through the body and the cellular mechanisms behind their effects are still not well understood, and there is an urgent need for standardized detection methods.
Impact of Microplastics on Human Health: A Comprehensive Review
This comprehensive review examines how microplastics enter the human body through food, water, and air, and what health effects they may cause. Researchers found evidence that microplastics can accumulate in the body and may contribute to inflammation, oxidative stress, and disruption of gut bacteria. The study suggests that more research is needed to fully understand the long-term health implications of ongoing human exposure to microplastics.
Microplastic and nanoplastic transfer, accumulation, and toxicity in humans
Researchers reviewed human exposure routes to micro- and nanoplastics — via air, water, and food — and summarized reported toxicological outcomes, identifying ingestion and inhalation as primary entry points and flagging oxidative stress, inflammation, and endocrine disruption as key health concerns warranting further study.
Integrating aggregate exposure pathway and adverse outcome pathway for micro/nanoplastics: A review on exposure, toxicokinetics, and toxicity studies
This review brings together research on how micro and nanoplastics enter the human body, where they go once inside, and what harm they may cause, using a framework that links exposure pathways to health outcomes. Studies show these tiny particles can be absorbed through the gut, lungs, and skin, and may accumulate in organs like the liver and kidneys. The paper highlights that micro and nanoplastics can trigger inflammation, oxidative stress, and disruption of hormones, though more research is needed to fully understand the long-term health risks.
Microplastics and human health: unraveling the toxicological pathways and implications for public health
This review pulls together recent research on how microplastics enter the human body and cause cellular damage through inflammation, oxidative stress, and direct cell injury. The authors highlight that microplastics can also amplify the harmful effects of other environmental pollutants they carry, creating combined health risks that are greater than either threat alone.
Exposure Pathways, Systemic Distribution, and Health Implications of Micro- and Nanoplastics in Humans
This review summarizes how micro- and nanoplastics enter the human body through food, air, and skin, then distribute to organs throughout the body. Research in animal and cell models shows these particles can cause oxidative stress, inflammation, brain toxicity, reproductive problems, and potentially cancer, though standardized methods for assessing real-world human health risks are still needed.
Understanding the human health impacts of environmental micro- and nanoplastics
This review summarized current understanding of how micro- and nanoplastic particles enter the human body through food and air, accumulate in tissues, and cause health effects through oxidative stress, inflammation, and endocrine disruption, with a focus on gaps in knowledge about long-term human health impacts.
Human exposure to micro- and nanoplastic: biological effects and health consequence
This review summarized the biological effects and health consequences of human exposure to micro- and nanoplastics, covering routes of uptake (ingestion, inhalation, dermal), cellular toxicity mechanisms, and systemic health risks identified in recent experimental and epidemiological studies.
Micro-and Nanoplastic-Induced Biochemical Toxicity: Emerging Mechanisms and Health Risks Across Biological Systems
This comprehensive review synthesizes current understanding of how micro- and nanoplastics cause biochemical toxicity across biological systems, from plants and invertebrates to vertebrates and humans. Key mechanisms include oxidative stress, membrane disruption, immune activation, genotoxicity, endocrine disruption, and microbiome perturbation, all modulated by particle size, shape, and surface chemistry. The authors highlight critical gaps in standardization, chronic low-dose effect data, and the need for translatable biomarkers for risk assessment.