We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Exposure Pathways, Systemic Distribution, and Health Implications of Micro- and Nanoplastics in Humans
AI summary Read the abstract
This review summarizes how micro- and nanoplastics enter the human body through food, air, and skin, then distribute to organs throughout the body. Research in animal and cell models shows these particles can cause oxidative stress, inflammation, brain toxicity, reproductive problems, and potentially cancer, though standardized methods for assessing real-world human health risks are still needed.
Plastics have become integral to modern life; however, their widespread use and persistent nature have resulted in significant environmental contamination, especially by microplastics (MPs < 5 mm) and nanoplastics (NPs < 100 nm). These plastic particles can enter the human body via ingestion, inhalation, or dermal absorption, raising substantial concerns about their potential health impacts. Recent studies using zebrafish, rodent models, and human cell lines have begun to elucidate the mechanisms underlying micro- and nanoplastics (MNPs)-induced toxicity. These mechanisms include oxidative stress, inflammation, disruption of metabolic processes, neurotoxicity, reproductive dysfunction, and carcinogenicity. Despite these advances, significant knowledge gaps remain. There remains a lack of comprehensive reviews that systematically evaluate these effects across major human organ systems and address how MNPs cross biological barriers in the human body. This review addresses these gaps by summarizing the available evidence on MNPs’ toxicity, critically discussing their absorption, distribution, metabolism, and the associated cellular and molecular mechanisms of action. Furthermore, it outlines urgent research priorities, emphasizing the need for standardized analytical protocols, realistic exposure models, and extended epidemiological research to evaluate human health risks posed by MNPs accurately. In addition, the adoption of precautionary regulatory actions is recommended to mitigate exposure and safeguard public health.
More Papers Like This
A review on microplastics and nanoplastics in the environment: Their occurrence, exposure routes, toxic studies, and potential effects on human health
AI summary Read the abstract
This review summarizes what is known about how microplastics and nanoplastics enter the human body through food, air, and skin contact, and what they do once inside. Studies on cells and animals show these tiny particles can cause oxidative stress, DNA damage, inflammation, and harm to the immune, digestive, reproductive, and nervous systems. The research makes clear that microplastics are not just an environmental problem but a direct concern for human health.
Micro- and Nanoplastics on Human Health and Diseases: Perspectives and Recent Advances
AI summary Read the abstract
This review provides a comprehensive overview of how micro- and nanoplastics enter the human body through ingestion, inhalation, and skin absorption, and how they can then travel through the bloodstream to reach virtually every organ. Researchers summarize evidence that these particles can trigger inflammation, oxidative stress, and disruption of hormonal and immune functions. The study emphasizes that the ability of these particles to cross biological barriers and accumulate in tissues makes understanding their long-term health effects an urgent research priority.
The exposure routes of micro- and nanoplastics and their potential toxic effects on human health
AI summary Read the abstract
This review summarized current knowledge about how micro- and nanoplastics enter the human body through breathing, eating, and skin contact. The study discusses evidence from laboratory and animal studies suggesting these particles may affect the reproductive, respiratory, digestive, and immune systems, though researchers note that more human studies are needed to fully understand the health implications.
Micro and Nanoplastics on Human Health and Diseases: Perspectives and Recent Advances
AI summary Read the abstract
This review covers how micro- and nanoplastic particles enter the human body through ingestion, inhalation, infusion, and skin absorption, distribute to virtually all tissues and organs via the circulatory system, and cause health impacts including inflammatory responses, cellular damage, and endocrine disruption.
Human exposure to microplastics: A review on exposure routes and public health impacts
AI summary Read the abstract
This review examines how microplastics enter the human body through food, air, and skin contact and the health effects they can cause, including oxidative stress, inflammation, hormone disruption, and potential DNA damage. Despite growing evidence of harm, the exact routes plastics take through the body and the cellular mechanisms behind their effects are still not well understood, and there is an urgent need for standardized detection methods.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.