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Systematic Review ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 1 ? Systematic review or meta-analysis. Synthesizes findings across many studies. Strongest evidence. Food & Water Human Health Effects Marine & Wildlife Nanoplastics Policy & Risk Remediation Sign in to save

A Systematic Review on the Impact of Micro-Nanoplastics Exposure on Human Health and Diseases

Biointerface Research in Applied Chemistry 2022 18 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Kannabiran Krishnan, M Paul, V Stock, J Cara-Carmona, E Lisicki, S Shopova, V Fessard, A Braeuning, H Sieg, L Bohmert, C Campanale, C Massarelli, I Savino, V Locaputo, V Uricchio, V Parvathi, N Yoghalakshmi, S Kumar, P Athulya, H Ageel, S Harrad, M Abdallah, H Yadav, S; Sethulekshmi, A Shriwastav, A Rodrigues, G De Jesus, D Waked, G Gomes, T Silva, V Yariwake, M Da Silva, A Magaldi, M Veras, S Rist, C Almroth, N Hartmann, T Karlsson, P Gopinath, V Saranya, S Vijayakumar, M Meera, S Ruprekha, R Kunal, A Pranay, J Thomas, A Mukherjee, N Chandrasekaran, T Zheng, D Yuan, C Liu, S Wieland, A Balmes, J Bender, J Kitzinger, F Meyer, A Ramsperger, Roeder, F Tengelmann, B Wimmer, C Laforsch, H Kress, A Vianello, R Jensen, L Liu, J Vollertsen, C Mirande, J Gasperi, S Wright, R Dris, F Collard, C Mandin, M Guerrouache, V Langlois, F Kelly, B Tassin, M Blsing, W Amelung, F Meng, T Fan, X Yang, M Riksen, M Xu, W Geissen, K Zhang, H Shi, J Peng, Y Wang, X Xiong, C Wu, P Lam

Summary

This systematic review summarizes existing research on how micro and nanoplastic exposure affects human health and may contribute to disease. The evidence suggests that these tiny particles can enter the body through food, water, air, and even cosmetics, potentially causing inflammation, oxidative stress, and disruptions to the immune and reproductive systems.

Body Systems
Cardiovascular Hepatic Immune Nervous Renal Respiratory
Models
Human
Study Type Review

Plastic production is continuously increasing worldwide for daily use. Micro-plastics and nano-plastics remain major emerging pollutants and threaten the environment, ecosystem, human health, and well-being. Micro-nanoplastics (MNPs) are also exposed to humans through cosmetics, inhalation, ingestion, drinking water, dietary sources, and drug formulations. Oral uptake is the major among the different exposure routes of MNPs to humans. After entry, it gets absorbed due to its nano size (˂100 nm) and easily distributed to all parts of the body through blood, affecting multiple organs, especially vital organs of the human body leading to severe diseases. It causes cancer, heart, liver, and kidney diseases, crosses the blood-brain barrier, and affects the brain. Its adsorption with protein leads to multi-layered corona formation in human blood plasma. MNPs interact with immune cells and induce pro-inflammatory mediators, inflammatory reactions, reactive oxygen species (ROS) production, and associated cytotoxicity. MNPs suppress T lymphocyte activity which results in a lack of immune regulation leading to autoimmune diseases. Hence, it is necessary to understand the impact of MNPs exposure on humans. Strict control measures for the production and use of plastics and developing appropriate strategies for safe disposal would prevent MNPs-mediated toxicity in humans.

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