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61,005 resultsShowing papers similar to Semi-quantitative Assessment of the Distribution of Microplastic Particles of Different Size in the Liver of Rat
ClearSemiquantitative assessment of the distribution of microplastic particles in the body during acute exposure
Researchers developed and validated a semi-quantitative method to assess microplastic distribution across organs in rats under acute exposure conditions, using fluorescent particles of three sizes (100, 500, 1000 nm) to map accumulation patterns — finding size-dependent biodistribution with smaller particles reaching more tissues.
Comparative analysis of accumulation of microplastics of various sizes in the rat brain based on an automated morphometric approach
Researchers injected fluorescent polystyrene microparticles (100, 500, and 1000 nm) intracardiacally into female Wistar rats and compared accumulation in brain tissue using a novel semi-quantitative morphometric approach, finding that 100 nm particles showed the greatest brain penetration and accumulation.
Exploring the Impacts of Polyethylene Microplastics on Rat Liver
Wistar rats exposed to polyethylene microplastics at 0.1–5 mg/kg for 4 weeks showed dose-dependent PE accumulation in liver tissue confirmed by fluorescence microscopy, with histopathological signs of liver injury despite no significant change in body weight.
Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice
This study found that smaller plastic particles spread more widely through the bodies of mice and caused more organ damage than larger ones, particularly in the liver, kidneys, and heart. Nanoplastics (under 1 micrometer) were especially concerning because they crossed biological barriers more easily than microplastics. The results suggest that the tiniest plastic particles in our environment may pose the greatest health risks.
Histological, enzymatic and chemical analyses of the potential effects of differently sized microplastic particles upon long-term ingestion in zebrafish (Danio rerio)
Researchers exposed zebrafish to microplastics of varying sizes for extended periods and conducted histological and biochemical analyses, finding no evidence of particle translocation to liver in properly controlled experiments and calling for critical reassessment of studies claiming large microplastics cross biological barriers.
Kidney and Liver Disorders Due to Microplastic Exposure: Chronic in Vivo Study in Male White Rats
Male white rats were chronically exposed to microplastics (particles 5 mm or smaller) to assess kidney and liver toxicity, with exposure resulting from environmental weathering and ultraviolet irradiation of plastic materials. The study found measurable histopathological and biochemical damage in both organs, confirming that long-term microplastic exposure causes organ-level injury in mammals.
Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver
Researchers exposed zebrafish to polystyrene microplastics of two different sizes and tracked where the particles accumulated in the body. They found that smaller particles (5 micrometers) built up in the gills, liver, and gut, while larger particles (20 micrometers) mainly stayed in the gills and gut. The microplastics caused liver inflammation, oxidative stress, and disrupted fat metabolism, suggesting that ingested microplastics can damage internal organs in fish.
Differentiation in the expression of toxic effects of polyethylene-microplastics on two freshwater fish species: Size matters
Researchers exposed zebrafish and perch to two sizes of polyethylene microplastics for 21 days and found that smaller particles were more toxic, accumulating primarily in the liver while larger ones concentrated in the gills. Both sizes triggered oxidative stress, DNA damage, and activated cell death pathways in both species. The study demonstrates that microplastic particle size is a key factor in determining where the particles end up in fish tissues and how severely they cause harm.
A new insight of size-dependent plastics particles kinetics with regarding of metabolomics effects in liver and kidney
Researchers developed a comprehensive extraction and detection protocol to track polystyrene particles of three sizes (80 nm, 2 µm, and 20 µm) across multiple organs in exposed animals, finding that smaller particles accumulated more broadly — reaching the brain, liver, spleen, and kidney — while liver and kidney metabolism was disrupted in size-dependent but distinct ways.
Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
Researchers fed mice polystyrene microplastics of two sizes and tracked where the particles accumulated in the body, finding them in the liver, kidneys, and gut with distribution patterns depending on particle size. Biochemical analysis revealed that microplastic exposure disrupted energy and fat metabolism, caused oxidative stress, and altered markers of neurotoxicity in the blood. The study provides evidence that microplastics can accumulate in mammalian tissues and may pose widespread health risks.
The size-dependent effects of nanoplastics in mouse primary hepatocytes from cells to molecules
Researchers studied how different sizes of nanoplastics affect mouse liver cells, finding that particle size significantly influences toxicity. Larger nanoplastics were more harmful at low doses, while smaller particles caused greater damage at high doses by more effectively penetrating cells and disrupting enzyme function. The study suggests that nanoplastic size is a critical factor in determining potential liver health risks.
Uptake and depuration kinetics of microplastics with different polymer types and particle sizes in Japanese medaka (Oryzias latipes)
Researchers studied the uptake and depuration kinetics of microplastics with different polymer types and sizes in Japanese medaka fish. They found that smaller particles accumulated more readily in fish tissues and were retained longer than larger ones, with particle distribution varying by organ. The study provides important quantitative data on how microplastic characteristics influence their accumulation and clearance in fish, which is relevant to understanding food chain transfer.
Uptake and Effects of Micro‐, Submicro‐ and Nanoplastics Investigated on in vitro Models of the Intestinal Barrier and the Liver
Researchers investigated the uptake and toxic effects of micro-, submicro-, and nanoplastics using in vitro models of the intestinal barrier and liver to assess how plastic particles of different sizes interact with gastrointestinal and hepatic cells. The study examined cellular internalization, barrier integrity, and metabolic responses to characterize size-dependent toxicity mechanisms.
Size-dependent and tissue specific accumulation of polystyrene microplastics and nanoplastics in zebrafish
Researchers tracked size-dependent accumulation of polystyrene micro- and nanoplastics in multiple zebrafish tissues, finding that smaller particles distributed more broadly throughout the body compared to larger ones. Nanoplastics showed greater systemic distribution including into brain and reproductive tissues, raising concerns about size-dependent health risks.
Contrasting the distribution kinetics of microplastics and nanoplastics in medaka following exposure and depuration
This study tracked how micro and nanoplastics distribute across different organs in medaka fish over time after exposure and recovery. Nanoplastics spread to more organs including the brain, liver, and eyes, and were harder for the fish to clear than microplastics. The findings show that smaller plastic particles pose a greater risk because they travel further in the body and accumulate in organs, which has implications for understanding human exposure through seafood.
MassBalance Tracing of In Vivo Biodistribution,Relocation, and Excretion of Europium-Doped Micro/Nanoplastics inRats
This rat study used europium-labeled micro- and nanoplastics to track particle distribution in the body after intravenous administration, finding that most accumulated in the liver and spleen with very little reaching the brain or heart. The results suggest that standard biological filtration processes govern microplastic distribution following classical size-dependent rules.
[Exposure Pathways of Polystyrene Nanoplastics Mediate Their Cellular Distribution and Toxicity].
This study found that the route by which polystyrene nanoplastics enter the body determines which liver cell types accumulate the particles and what toxic effects occur, demonstrating that exposure pathway—not just dose—shapes nanoplastic toxicity in hepatic tissue.
Distribution and toxicity of submicron plastic particles in mice
Researchers found that orally administered submicron-sized microplastics distributed to multiple organs and biofluids in mice over four weeks, causing oxidative stress and inflammation in tissues including the liver, kidneys, and gut.
Distinctive lipidomic responses induced by polystyrene micro- and nano-plastics in zebrafish liver cells
Researchers compared how micro-sized and nano-sized polystyrene plastic particles affect fat metabolism in zebrafish liver cells. They found that both sizes were taken up by cells, but the smaller nanoplastics caused more pronounced disruptions to lipid profiles and triggered cell death pathways. The findings underscore that particle size matters when assessing the biological impact of plastic pollution on fish.
Size-Dependent Tissue Translocation and Physiological Responses to Dietary Polystyrene Microplastics in Salmo trutta
Researchers fed brown trout polystyrene microplastics of different sizes through their diet and tracked particle distribution and physiological effects, including a recovery period after exposure ended. They found that smaller microplastics were more likely to translocate from the gut to other organs, and that size significantly influenced where particles accumulated. The study provides important data on how microplastic size affects tissue distribution and physiological responses in a temperate freshwater fish.
Potential toxicity of microplastics on vertebrate liver: A systematic review and meta–analysis
This meta-analysis of 118 studies found that microplastics damage vertebrate livers by inducing oxidative stress and intracellular toxicity, altering biotransformation processes, and disrupting lipid metabolism. Organisms at earlier life stages, exposed to smaller particles, and for longer durations showed the greatest liver damage, with catalase, GST, reactive oxygen species, and alkaline phosphatase levels progressively increasing with microplastic concentration.
Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka (Oryzias melastigma)
Researchers exposed marine medaka fish to different sizes of polystyrene microplastics for 60 days and found that particle size was a key factor in determining health effects. Larger particles (200 micrometers) caused weight gain and fat accumulation, while smaller particles (2 and 10 micrometers) led to liver inflammation and damage. The study also revealed that microplastics disrupted the balance of gut bacteria, particularly with larger particle exposure.
Organ-specific distribution and size-dependent toxicity of polystyrene nanoplastics in Australian bass (Macquaria novemaculeata)
Researchers fed Australian bass fish nanoplastics of different sizes and found that smaller particles (50 nanometers) accumulated more in the brain and muscle tissue, while larger ones concentrated in the gut and liver. The smallest nanoplastics caused the most severe organ damage, including liver inflammation, gill changes, and brain tissue disruption. The study suggests that particle size plays a critical role in how nanoplastics distribute through the body and how much harm they cause.
The size-dependence and reversibility of polystyrene nanoplastics-induced lipid accumulation in mice: Possible roles of lysosomes
This mouse study found that smaller nanoplastics (100 nm) cause more fat buildup in the liver than larger ones (500 nm), showing that size matters when it comes to health effects. Encouragingly, the liver damage was reversible after the mice stopped being exposed, suggesting the body can recover once nanoplastic intake is reduced. The damage appears to work by disrupting the cell's waste-recycling system (lysosomes).