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Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice

International Journal of Nanomedicine 2024 36 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Bohai Du, Bohai Du, Tianlan Li, Tianlan Li, Haoqi He, Xun Xu, Chunmei Zhang, Chunmei Zhang, Xianzhu Lu, Xianzhu Lu, Yuhan Wang, Jingyi Cao, Jingyi Cao, Yinghan Lu, Yinghan Lu, Yiwa Liu, Yiwa Liu, Shanshan Hu, Juxiao Li, Juxiao Li, Li Li, Ming Shi

Summary

This study found that smaller plastic particles spread more widely through the bodies of mice and caused more organ damage than larger ones, particularly in the liver, kidneys, and heart. Nanoplastics (under 1 micrometer) were especially concerning because they crossed biological barriers more easily than microplastics. The results suggest that the tiniest plastic particles in our environment may pose the greatest health risks.

Polymers

Body Systems

Cardiovascular Hepatic Renal

Models

Mouse

Study Type In vivo

The biological distribution and toxicity of plastic particles in mice were more obvious with the decrease of particle size and the increase of concentration of plastic particles. Compared with MPs, NPs were easier to enter the tissues and produce changes in liver, kidney, and heart functions. Therefore, more attention should be paid to the toxicity of NPs.

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