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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Human Health Effects Nanoplastics Sign in to save

Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice

International Journal of Nanomedicine 2024 36 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Bohai Du, Tianlan Li, Haoqi He, Xun Xu, Chunmei Zhang, Xianzhu Lu, Yuhan Wang, Jingyi Cao, Yinghan Lu, Yiwa Liu, Shanshan Hu, Juxiao Li, Li Li, Ming Shi

Summary

This study found that smaller plastic particles spread more widely through the bodies of mice and caused more organ damage than larger ones, particularly in the liver, kidneys, and heart. Nanoplastics (under 1 micrometer) were especially concerning because they crossed biological barriers more easily than microplastics. The results suggest that the tiniest plastic particles in our environment may pose the greatest health risks.

Polymers
PS
Body Systems
Cardiovascular Hepatic Renal
Models
Mouse
Study Type In vivo

The biological distribution and toxicity of plastic particles in mice were more obvious with the decrease of particle size and the increase of concentration of plastic particles. Compared with MPs, NPs were easier to enter the tissues and produce changes in liver, kidney, and heart functions. Therefore, more attention should be paid to the toxicity of NPs.

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