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Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice
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This study found that smaller plastic particles spread more widely through the bodies of mice and caused more organ damage than larger ones, particularly in the liver, kidneys, and heart. Nanoplastics (under 1 micrometer) were especially concerning because they crossed biological barriers more easily than microplastics. The results suggest that the tiniest plastic particles in our environment may pose the greatest health risks.
The biological distribution and toxicity of plastic particles in mice were more obvious with the decrease of particle size and the increase of concentration of plastic particles. Compared with MPs, NPs were easier to enter the tissues and produce changes in liver, kidney, and heart functions. Therefore, more attention should be paid to the toxicity of NPs.
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Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
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Researchers fed mice polystyrene microplastics of two sizes and tracked where the particles accumulated in the body, finding them in the liver, kidneys, and gut with distribution patterns depending on particle size. Biochemical analysis revealed that microplastic exposure disrupted energy and fat metabolism, caused oxidative stress, and altered markers of neurotoxicity in the blood. The study provides evidence that microplastics can accumulate in mammalian tissues and may pose widespread health risks.
Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems
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Researchers exposed mouse and human liver cells and live mice to polystyrene nanoplastics of five different sizes and found that the smallest particles were most toxic in lab dishes, while medium and large particles caused the most liver damage in living animals. The larger particles triggered immune responses by recruiting inflammatory cells to the liver and intestines, causing tissue damage. This study reveals that nanoplastic size matters in unexpected ways, and that lab tests alone may not predict which particles are most dangerous in the body.
Blood uptake and urine excretion of nano- and micro-plastics after a single exposure.
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Mice exposed to polystyrene nanoparticles (100 nm) and microparticles (3 µm) via different routes showed that smaller particles appeared rapidly in blood and were detected in urine, while larger particles cleared more slowly. The study provides direct evidence that nanoplastics can cross biological barriers and enter circulation, with potential for distribution throughout the body.
Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics.
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Researchers found that after a single oral exposure in mice, nanoplastics were rapidly absorbed into the blood, accumulated in fat tissues, and crossed both the blood-brain and blood-testis barriers. The study demonstrated that the distribution and behavior of plastic particles in mammals is strongly dependent on particle size, with nanoplastics showing substantially greater tissue penetration than microplastics.
Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites
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A mouse study found that microplastics of different sizes cause damage to multiple organs, but in different ways. Smaller particles (0.5 micrometers) spread more widely through the body and caused more inflammation in the spleen, kidneys, heart, lungs, and liver, while larger particles (5 micrometers) caused worse gut damage and disrupted gut bacteria linked to brain inflammation. This suggests that the size of microplastics we are exposed to matters for which organs are most affected.
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