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Semi-quantitative Assessment of the Distribution of Microplastic Particles of Different Size in the Liver of Rat
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Researchers examined the distribution of microplastic particles of different sizes (500 nm and 1000 nm) in rat liver tissue using semi-quantitative fluorescent staining, finding that particle size influenced the distribution pattern and intensity of MP accumulation within hepatic tissue.
The paper presents data on a study of the distribution of microplastic particles of different size (500 and 1000 nm) in the liver of experimental rats. A semi-quantitative assessment method using fluorescent staining was used for the analysis. In order to identify the distribution and intensity of microplastic accumulation in animal tissues, particles were injected as intracardiac administration, afterwards the histological samples were studied using microscopy and a comparative analysis of the level of particle distribution in the liver. The data obtained revealed a clear dependence of microplastic accumulation on its size: the highest concentration was observed for 1000 nm particles, which was confirmed by a pronounced increase of fluorescence in this group. It was found that larger particles (1000 nm) are distributed in the liver in significantly larger quantities compared to 500 nm particles and control samples, which emphasizes the influence of particle size on their distribution in the body.
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