We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Uptake and Effects of Micro‐, Submicro‐ and Nanoplastics Investigated on in vitro Models of the Intestinal Barrier and the Liver
AI summary Read the abstract
Researchers investigated the uptake and toxic effects of micro-, submicro-, and nanoplastics using in vitro models of the intestinal barrier and liver to assess how plastic particles of different sizes interact with gastrointestinal and hepatic cells. The study examined cellular internalization, barrier integrity, and metabolic responses to characterize size-dependent toxicity mechanisms.
Prof. Dr. Albert Braeuning (Bundesinstitut fr Risikobewertung
More Papers Like This
Complex intestinal and hepatic in vitro barrier models reveal information on uptake and impact of micro-, submicro- and nanoplastics
AI summary Read the abstract
Using laboratory models of human intestinal and liver barriers, researchers studied how plastic particles of different sizes cross from the gut into the body. Smaller nanoplastics (25 nm) were more readily taken up than larger microplastics, and the intestinal mucus layer provided some protection against particle absorption. The study also found signs of oxidative stress and changes in how liver cells process foreign substances after plastic exposure, providing insight into how ingested microplastics could affect human organs.
Beyond microplastics - investigation on health impacts of submicron and nanoplastic particles after oral uptake in vitro
AI summary Read the abstract
Researchers compared how human intestinal and liver cells take up microplastics versus submicron and nanoplastics and found that smaller plastic particles (under 1 micrometer) pass through gut cells in larger amounts and behave differently depending on their chemical makeup. The findings suggest nanoplastics from contaminated food and beverages may be more bioavailable — meaning more likely to enter the body — than larger microplastic particles.
Mechanisms of ingested polystyrene micro-nanoplastics (MNPs) uptake and translocation in an in vitro tri-culture small intestinal epithelium
AI summary Read the abstract
Researchers used a sophisticated laboratory model of the human small intestine to study how micro- and nanoplastics cross the gut barrier after simulated digestion. They found that smaller nanoplastics were absorbed more efficiently than larger microplastics, and the particles used multiple cellular pathways to cross the intestinal lining. The study provides new evidence about the mechanisms by which ingested plastic particles could potentially reach the bloodstream.
Toxicity, uptake, and nuclear translocation of ingested micro-nanoplastics in an in vitro model of the small intestinal epithelium
AI summary Read the abstract
Researchers tested the toxicity and uptake of various micro- and nanoplastics in a laboratory model of the small intestinal lining. They found that carboxylated nanoplastics significantly reduced cell viability and increased intestinal permeability, with the smallest particles (25 nm) showing the greatest uptake. Strikingly, some nanoplastic particles were found inside cell nuclei, suggesting they can penetrate deep into cellular structures after ingestion.
Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)
AI summary Read the abstract
This review summarizes how microplastics and nanoplastics can damage the gastrointestinal tract and disrupt liver metabolism when they enter the human body. The particles trigger oxidative stress, inflammation, and cell death in gut tissues, and can interfere with how the liver processes glucose and fats. As plastics continue to break down into ever-smaller particles, the potential for harm increases because nanoplastics can penetrate cells more easily.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.