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61,005 resultsShowing papers similar to Assessment of the cytotoxicity micro- and nano-plastic on human intestinal Caco-2 cells and the protective effects of catechin.
ClearNanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells
Researchers tested how polystyrene nanoparticles interact with human intestinal cells in the lab. They found that the nanoparticles were readily taken up by the cells in a concentration-dependent manner, but no significant toxic effects were observed under the conditions tested. The study suggests that while nanoplastics can enter gut cells, their short-term toxicity at the tested levels appears limited.
Green tea extracts rich in epicatechins inducing aggregation and inhibiting absorption of amine surface functionalized polystyrene microplastics in vitro mimick system
Researchers investigated whether green tea extracts containing 35% epicatechins affect the bioaccessibility of amine-functionalized polystyrene microplastics using in vitro digestion with a Caco-2 cell model, measuring effects on intestinal membrane integrity, microplastic absorption, and aggregation behavior.
The effects of polystyrene microplastics on human intestinal cells health and function
This study examined how polystyrene microplastics affect normal and cancer intestinal cells, addressing a gap left by previous research that used only cancer cell lines and pristine plastics. The work evaluated microplastic toxicity under more realistic conditions including digestive system biotransformation, assessing effects on nutrient uptake and cellular function.
Pro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines
Researchers tested the effects of polystyrene microplastics on human and mouse intestinal cell lines. They found that microplastic exposure increased cell death and triggered inflammatory responses, including the release of inflammatory signaling molecules. The study suggests that microplastics may promote inflammation in the gut lining, which could have implications for digestive health.
Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models
Researchers studied how the human digestive process transforms polystyrene microplastics and affects their intestinal toxicity using in vitro Caco-2 cell models. The study found that digestion formed a corona on microplastic surfaces without altering their chemical composition, and that smaller particles (100 nm) showed higher toxicity than larger ones (5 micrometers) regardless of digestive treatment.
A novel 3D intestine barrier model to study the immune response upon exposure to microplastics
Scientists developed a three-dimensional in vitro intestinal model using human epithelial cell lines (Caco-2 and HT-29) to study the immune response to ingested microplastics, finding that microplastics induced inflammatory cytokine release and altered barrier integrity in a dose-dependent manner.
Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells.
Researchers exposed human intestinal organoid-derived epithelial tissue models with and without M cells to polystyrene micro- and nano-plastics, finding that nano-plastics caused greater disruption of barrier integrity and uptake than micro-plastics, and that M cell-containing models showed enhanced particle translocation compared to standard epithelial models.
An inverted in vitro triple culture model of the healthy and inflamed intestine: Adverse effects of polyethylene particles.
Using a laboratory model of the human intestinal lining, researchers tested how polyethylene microplastics affect intestinal cells and found they disrupted the barrier function of the gut wall. A compromised intestinal barrier allows larger molecules and particles to pass into the body, which could amplify the health effects of microplastic ingestion.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review of 30 in vitro studies found that microplastics and nanoplastics cause size- and concentration-dependent damage to human gastrointestinal cells, including increased oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Smaller particles consistently showed greater cellular uptake and biological effects, though chronic low-dose exposure generally produced minimal impacts.
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Researchers studied how polystyrene microplastics of different sizes and charges are transported across intestinal cells, and whether green tea extracts can reduce that absorption. The study suggests that green tea extracts may help strengthen the intestinal barrier, reduce microplastic transport into the body, and lower the oxidative stress that certain microplastics cause in cells.
Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
This review examines the evidence on how nano- and microplastics affect the immune system and intestinal health. The findings suggest that exposure to these particles can disrupt the gut microbiome and impair critical intestinal barrier functions, potentially contributing to the development of chronic inflammatory and immune conditions.
Micro-sized polyethylene particles affect cell viability and oxidative stress responses in human colorectal adenocarcinoma Caco-2 and HT-29 cells
Researchers tested the effects of micro-sized polyethylene particles on two types of human colon cancer cells commonly used in gut research. The microplastics reduced cell survival and triggered oxidative stress, which is a type of cellular damage caused by an imbalance of harmful molecules. This study provides evidence that microplastics reaching the human gut through food and water could damage intestinal cells, though more research is needed at real-world exposure levels.
Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells
Researchers studied how human intestinal Caco-2 cells take up polystyrene plastic particles of five different sizes ranging from 300 nanometers to 6 micrometers. The study found that smaller particles were taken up at higher rates and that co-exposure with bisphenol A increased cellular toxicity, suggesting that nanoscale plastics may pose a greater risk to human intestinal cells than larger microplastics.
Polystyrene Microplastics of Varying Sizes and Shapes Induce Distinct Redox and Mitochondrial Stress Responses in a Caco-2 Monolayer
Researchers tested three sizes and shapes of polystyrene microplastics on human intestinal cells and found that all were taken up by the cells, with the smallest particles (200 nm) causing the most pronounced effects on cellular stress responses. The microplastics triggered changes in antioxidant gene expression and mitochondrial activity. The study suggests that the number of particles a cell absorbs, driven largely by particle size, determines the severity of the stress response.
Impact of polyethylene nanoplastics on human intestinal cells
Researchers tested the effects of polyethylene nanoplastics on human intestinal cell lines and found that particles prepared with cationic chemical initiators caused significant cell damage, oxidative stress, and DNA damage over time. Cells that produce a protective mucus layer were largely unaffected, suggesting that mucus may serve as a natural defense. The findings indicate that the surface chemistry of nanoplastics, not just their size, plays a critical role in determining their toxicity to gut tissue.
Exposure to polystyrene nanoparticles leads to dysfunction in DNA repair mechanisms in Caco-2 cells
Researchers found that exposing intestinal cells (Caco-2) to polystyrene nanoplastics impaired DNA repair mechanisms even at doses that didn't kill the cells, raising concern that nanoplastic exposure could lead to genetic instability and long-term health risks over time.
Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells
Researchers compared how two sizes of polystyrene microplastics affect human intestinal cells grown in the lab. While both sizes showed low direct toxicity, they disrupted mitochondrial function and inhibited important cellular transport pumps that normally help remove harmful substances from cells. The findings suggest that microplastics in the gut could interfere with how intestinal cells handle drugs and toxins, even at concentrations that do not cause obvious cell damage.
Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine
Researchers tested the acute toxicity of polystyrene and polyvinyl chloride micro- and nanoparticles using an advanced triple-culture model of the human intestinal barrier, including both healthy and inflamed conditions. They found that the plastic particles did not cause significant acute toxicity at the concentrations tested, though the inflamed intestinal model showed greater particle uptake. The study suggests that while short-term exposure may not cause immediate damage, chronic exposure and pre-existing inflammation could influence how the body handles ingested microplastics.
Micro(nano)plastics in food system: potential health impacts on human intestinal system.
This review assessed how micro(nano)plastics in the human food system reach the intestine and accumulate in the gut, summarizing evidence that they can alter intestinal barrier function, trigger inflammation, and disrupt the gut microbiome, with implications for long-term digestive health.
The role of human intestinal mucus in the prevention of microplastic uptake and cell damage
Researchers studied how the mucus lining of the human intestine acts as a barrier against microplastic particles of different sizes and surface coatings. The mucus layer significantly reduced microplastic uptake by cells and protected against toxicity and inflammation. This study suggests that a healthy intestinal mucus layer is an important natural defense against the harmful effects of swallowed microplastics.
Impact of Environmental Microplastic Exposure on Caco-2 Cells: Unraveling Proliferation, Apoptosis, and Autophagy Activation
Researchers exposed human intestinal cells to polyethylene and PET microplastics of different sizes and observed significant decreases in cell survival along with increased oxidative stress. The microplastics triggered both programmed cell death (apoptosis) and the cell's self-recycling process (autophagy), with effects varying by particle size. The study suggests that microplastic exposure may compromise the intestinal barrier through multiple pathways of cellular damage.
Uptake and cellular effects of PE, PP, PET and PVC microplastic particles
Researchers tested intestinal uptake and cytotoxicity of PE, PP, PET, and PVC microplastic particles using human cell lines and found that 1–4 µm polyethylene particles crossed the intestinal epithelium at significantly higher rates than polystyrene, though cytotoxic effects only appeared at concentrations far above realistic dietary exposure.
Polystyrene microplastics with absorbed nonylphenol induce intestinal dysfunction in human Caco-2 cells
Researchers exposed human intestinal cells to polystyrene microplastics carrying the pollutant nonylphenol and found the combination caused oxidative stress, inflammation, and damage to the intestinal barrier. The damaged barrier allowed more microplastics to pass through, and the smallest particles (0.1 micrometers) acted as a "chemosensitizer" that made cells less able to detect and respond to other toxic substances over time. This study suggests that microplastics carrying absorbed pollutants could damage the gut lining and increase the body's vulnerability to other harmful chemicals in food and water.
Preliminary Study on the Toxic Effects of Polystyrene Microplastics in Human Colorectal Cells
Researchers tested the toxic effects of polystyrene microplastics on human colorectal cells in the laboratory and found that both 80-nanometer and 500-nanometer particles significantly reduced cell viability and induced programmed cell death. The effects were size- and concentration-dependent, with smaller particles generally causing greater toxicity, providing experimental evidence for evaluating the intestinal health risks of microplastic exposure.