We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Preliminary Study on the Toxic Effects of Polystyrene Microplastics in Human Colorectal Cells
Summary
Researchers tested the toxic effects of polystyrene microplastics on human colorectal cells in the laboratory and found that both 80-nanometer and 500-nanometer particles significantly reduced cell viability and induced programmed cell death. The effects were size- and concentration-dependent, with smaller particles generally causing greater toxicity, providing experimental evidence for evaluating the intestinal health risks of microplastic exposure.
According to this rapid urbanization background, the widespread presence of microplastics in the environment, caused by plastic pollution and poor waste management, poses a huge threat to public health. This research aims to evaluate the colorectal health risk associated with microplastics and provides data for managing urban water and food security. We have evaluated the toxic impact of different sizes (80 nm and 500 nm) of polystyrene microplastics (PS-MPs) on human colorectal cells (NCM460). Analyses were conducted to assess changes in cell viability, cell cycle, and apoptotic response after exposure to PS-MPs of varying particle sizes and concentrations. Our results revealed that 80 nm and 500 nm PS-MPs significantly reduced cell viability, induced cell apoptosis, and prolonged the time that cells stay in the S-phase. These results demonstrated a size-and concentration-dependent toxic effect. Therefore, this investigation provides experimental evidence for evaluating the intestinal health risks of microplastics, and calls for the optimization of the water treatment process in the field of environmental engineering to achieve targeted removal of these high-risk microplastics.
Sign in to start a discussion.
More Papers Like This
Preliminary Study on the Toxic Effects of Polystyrene Microplastics in Human Colorectal Cells
Researchers evaluated the toxic effects of polystyrene microplastics in two sizes, 80 nanometers and 500 nanometers, on human colorectal cells in laboratory culture. They found that both sizes significantly reduced cell viability, induced cell death, and disrupted the normal cell cycle in a dose-dependent manner. The study provides preliminary evidence that microplastic particles at sizes relevant to human exposure may pose risks to intestinal cell health.
The potential effects of microplastic pollution on human digestive tract cells
Researchers tested polystyrene particles of four different sizes on human colon and small intestine cells to assess the potential effects of microplastic ingestion. They found that the smallest nanoscale particles were more readily taken up by cells and caused greater reductions in cell viability and increased oxidative stress. The study suggests that smaller plastic particles may pose a greater risk to the human digestive tract than larger ones.
The effects of polystyrene microplastics on human intestinal cells health and function
This study examined how polystyrene microplastics affect normal and cancer intestinal cells, addressing a gap left by previous research that used only cancer cell lines and pristine plastics. The work evaluated microplastic toxicity under more realistic conditions including digestive system biotransformation, assessing effects on nutrient uptake and cellular function.
Pro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines
Researchers tested the effects of polystyrene microplastics on human and mouse intestinal cell lines. They found that microplastic exposure increased cell death and triggered inflammatory responses, including the release of inflammatory signaling molecules. The study suggests that microplastics may promote inflammation in the gut lining, which could have implications for digestive health.
Elucidating the Size‐Dependency of In Vitro Digested Polystyrene Microplastics on Human Intestinal Cells Health and Function
Polystyrene microplastics of different sizes were subjected to simulated in vitro digestion and then applied to human intestinal cells, with smaller particles causing greater disruption to cell health and barrier function than larger ones. The results suggest that the smallest microplastics reaching the human gut pose the greatest risk to intestinal integrity.