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Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells
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Researchers tested how polystyrene nanoparticles interact with human intestinal cells in the lab. They found that the nanoparticles were readily taken up by the cells in a concentration-dependent manner, but no significant toxic effects were observed under the conditions tested. The study suggests that while nanoplastics can enter gut cells, their short-term toxicity at the tested levels appears limited.
Our results show that both nPS are easily internalized by Caco-2 cells in a concentration-dependent manner, but no relevant toxic effects are observed under the analyzed exposure conditions.
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Interactions of polystyrene nanoplastics with in vitro models of the human intestinal barrier
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Researchers assessed the effects of polystyrene nanoparticles on two in vitro models simulating the human intestinal barrier and its associated immune system. The study found that while cell viability and membrane integrity were largely maintained, the nanoparticles were able to interact with and translocate across the intestinal cell layers, raising questions about potential long-term exposure effects.
Exposure to polystyrene nanoparticles leads to dysfunction in DNA repair mechanisms in Caco-2 cells
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Researchers found that exposing intestinal cells (Caco-2) to polystyrene nanoplastics impaired DNA repair mechanisms even at doses that didn't kill the cells, raising concern that nanoplastic exposure could lead to genetic instability and long-term health risks over time.
Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells
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Researchers studied how human intestinal Caco-2 cells take up polystyrene plastic particles of five different sizes ranging from 300 nanometers to 6 micrometers. The study found that smaller particles were taken up at higher rates and that co-exposure with bisphenol A increased cellular toxicity, suggesting that nanoscale plastics may pose a greater risk to human intestinal cells than larger microplastics.
Long-Term Effects of Polystyrene Nanoplastics in Human Intestinal Caco-2 Cells
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Researchers exposed human intestinal cells to polystyrene nanoplastics over an extended period to simulate chronic dietary exposure. They found that long-term exposure at low concentrations caused subtle but persistent changes in cell function, including altered gene expression and increased oxidative stress markers. The study highlights that the health effects of nanoplastics may build up gradually over time, underscoring the importance of studying chronic rather than just short-term exposure.
Interactions between polystyrene nanoparticles and human intestinal epithelial Caco-2 cells
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Researchers traced how 70 nm polystyrene nanoplastics enter and exit human intestinal Caco-2 cells, finding that particles accumulate in lysosomes and mitochondria over 72 hours and are cleared primarily through the lysosomal pathway, with serum in the medium inhibiting that clearance.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.