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61,005 resultsShowing papers similar to Molecular toxicity of nanoplastics involving in oxidative stress and desoxyribonucleic acid damage
ClearMicro- and nanoplastic induced cellular toxicity in mammals: A review
This review examines research on how micro- and nanoplastics cause cellular damage in mammalian systems, covering both laboratory and animal studies. Evidence indicates that these particles can trigger oxidative stress, inflammation, and DNA damage in cells, with smaller nanoplastics generally showing greater toxicity due to their ability to penetrate cell membranes more readily.
Bioeffects of Nanoplastics: DNA Damage and Mechanism
This review examines how nanoplastics, plastic particles smaller than one micrometer, can damage DNA in cells. The authors explain that nanoplastics may cause genetic damage through oxidative stress, inflammation, and direct interference with cellular processes, which raises concerns about potential long-term health effects including cancer risk.
Research progress on the cellular toxicity caused by microplastics and nanoplastics
This review summarizes current research on how microplastics and nanoplastics cause damage at the cellular level. Researchers identified four main ways these particles harm cells: triggering oxidative stress, damaging cell membranes and organelles, causing inflammation, and disrupting DNA. The findings highlight growing evidence that plastic particles small enough to enter cells can interfere with fundamental biological processes.
Biomarkers of oxidative stress, inflammation, and genotoxicity to assess exposure to micro- and nanoplastics. A literature review
This systematic review summarizes research on biomarkers that can measure oxidative stress, inflammation, and DNA damage caused by micro and nanoplastic exposure. Identifying reliable biomarkers is a crucial step toward understanding exactly how microplastics affect human health and developing tools to monitor exposure in people.
Toxicity of metal-based nanoparticles: Challenges in the nano era
This review covers the toxic effects of metal-based nanoparticles on human health, including how they cause oxidative stress, inflammation, DNA damage, and organ dysfunction. While focused on engineered nanoparticles rather than microplastics directly, the toxicity pathways described overlap significantly with those triggered by nanoplastic exposure. Understanding these shared mechanisms helps explain how nano-scale particles of any kind, including nanoplastics, may harm the body.
Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals—What We Know So Far
This review summarized known cellular and systemic effects of micro- and nanoplastics in mammals, finding that while ingestion is common, knowledge of health impacts remains limited, with oxidative stress and inflammation as the most reported biological responses.
Recent consequences of micro-nanaoplastics (MNPLs) in subcellular/molecular environmental pollution toxicity on human and animals
This review examines the subcellular and molecular mechanisms by which micro- and nanoplastics cause toxicity in humans and animals, focusing on oxidative stress, inflammation, cell death pathways, and endocrine disruption at the cellular level.
Nanoplastics in the Environment: Sources, Fate, Toxicity, Challenges and Mitigation Strategies
This review covers the formation, environmental fate, and health risks of nanoplastics, emphasizing their capacity to penetrate biological barriers and cause oxidative stress, inflammation, DNA damage, and endocrine disruption, alongside current strategies for mitigation.
Cellular Impact of Micro(nano)plastics on Human Health: A Review.
This review examined how micro(nano)plastics (MNPs) entering the human body through ingestion, inhalation, and skin contact affect cells and tissues. It synthesized evidence of oxidative stress, inflammation, DNA damage, and endocrine disruption associated with MNP exposure.
Genotoxicity and Genomic Instability Induced by Micro- and Nanoplastics: A Comprehensive Multi-Taxa Mechanistic Review.
This review of existing research found that tiny plastic particles (microplastics and nanoplastics) can damage DNA in many different living things, from fish to human cells. The plastic particles cause this damage by creating harmful molecules called free radicals, disrupting the body's ability to repair DNA, and triggering inflammation. These findings suggest that the growing amount of plastic pollution in our environment could pose serious health risks to humans and wildlife.
Toxicity Induced by Micro-and Nanoplastics through Oxidative Stress: The Role of Co-Exposure to Other Chemical Pollutants
This review examined how micro- and nanoplastics cause oxidative stress — a form of cellular damage — in living organisms, particularly when combined with other chemical pollutants in the environment. Co-exposure to microplastics and chemicals like pesticides or heavy metals tends to be more damaging than either pollutant alone.
Genotoxic and neurotoxic potential of intracellular nanoplastics: A review
This review examines how nanoplastics, once inside human cells, could cause cancer and brain damage. At the cellular level, these tiny particles can disrupt waste-clearing processes, damage mitochondria, generate harmful free radicals, and directly damage DNA. In long-lived cells like neurons, nanoplastics may promote the buildup of toxic protein clumps linked to neurodegenerative diseases, while in rapidly dividing cells they could trigger tumor development.
Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects
This review examines the biological mechanisms by which micro- and nanoplastics may cause harm in humans, including oxidative stress, inflammation, disruption of protective barriers, and immune system problems. Evidence from lab and animal studies suggests these particles can affect the gut, heart, brain, and reproductive systems, though human data is still limited to detecting plastics in tissues rather than proving they cause specific diseases. The authors highlight that most studies use higher doses than people actually encounter, making it important to develop research models that better reflect real-world chronic exposure.
Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models
This review examines what animal and cell studies have revealed about how microplastics and nanoplastics cause harm at the molecular level, including promoting inflammation, oxidative stress, and cell death. Most research has focused on reproductive toxicity and polystyrene particles, while effects on the gut, brain, and heart remain understudied. The authors note that many experiments use unrealistic concentrations and synthetic particles, making it difficult to apply the results to real-world human exposure.
Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways
This review maps the biological harm caused by micro- and nanoplastics to formal toxicity pathways, finding that oxidative stress is a common starting point for damage at every level from cells to whole organisms. Researchers found that in ecological settings, this oxidative damage cascades into growth inhibition and behavioral changes, while in human health contexts it may trigger inflammatory responses. The study highlights that more mammalian research is needed to fully define the health risks of plastic particle exposure.
Effects of Micro‐ and Nanoplastics on Human Genome
This review examines the emerging evidence on how micro- and nanoplastics may interact with human genetic material, including potential effects on DNA integrity and gene expression. Researchers surveyed laboratory studies showing that these particles can induce oxidative stress and inflammatory responses in human cells, which are known pathways for genetic damage. The study highlights significant knowledge gaps and calls for more research into the long-term genomic effects of chronic microplastic exposure.
Cellular and Systemic Impacts of Microplastics and Nanoplastics
This review synthesized evidence on how micro- and nanoplastics cause cellular and systemic harm through inflammation, oxidative stress, mitochondrial dysfunction, and endocrine disruption across multiple organ systems. The authors emphasize that exposure is ubiquitous and that health impacts are no longer speculative.
Microplastics and Nanoplastics in Health Concerning Cellular Toxicity Mechanisms, Exposure Pathways, and Global Mitigation Strategies
This review synthesizes current knowledge on how micro- and nanoplastics cause cellular damage in the human body, covering mechanisms like oxidative stress, inflammation, DNA damage, and disruption of cell signaling pathways. Researchers note that exposure occurs through multiple routes including ingestion and inhalation, allowing particles to reach organs throughout the body. The study highlights significant gaps in understanding long-term and low-dose exposure effects that are most relevant to everyday human contact with these particles.
Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications
This review summarizes what is known about the toxicity of micro- and nanoplastics, noting they can cross critical barriers in the body including the blood-brain barrier. Studies in lab animals show these particles can cause DNA damage, oxidative stress, and cell death, with potential effects on the brain, heart, lungs, and skin, underscoring the need for more real-world human studies.
Insights into the potential carcinogenicity of micro- and nano-plastics.
This review examined existing evidence on the carcinogenic potential of micro- and nano-plastics, finding studies demonstrating genotoxicity, oxidative DNA damage, disruption of cell signaling, and tumor-promoting effects, while noting that direct human carcinogenicity data remain limited and mechanistic pathways require further investigation.
Microplastics and Oxidative Stress—Current Problems and Prospects
This review examines how microplastics cause oxidative stress, a condition where harmful molecules called free radicals damage cells. Microplastics have been linked to DNA damage, cell membrane disruption, mitochondrial problems, inflammation, and cell death, all driven by oxidative stress. These effects may contribute to serious health conditions including cancer and cardiovascular disease, though the authors note that more research is needed to fully understand the risks.
Nanoparticles: Weighing the Pros and Cons from an Eco-genotoxicological Perspective
This review assessed the eco-genotoxicological risks of nanoparticles including nanoplastics and metal oxide nanoparticles, examining their DNA-damaging potential across organisms from bacteria to mammals and finding that surface chemistry and dissolution behavior are the primary determinants of genotoxicity, with implications for environmental risk assessment frameworks.
Micro and nanoplastics in human carcinogenesis: Insights from in vitro studies
This narrative review compiles in vitro evidence on the carcinogenic effects of micro- and nanoplastics across multiple cancer types, examining mechanisms including oxidative stress, DNA damage, immune dysregulation, and epigenetic changes identified in cell culture experiments.
Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence
This review summarizes research showing that micro- and nanoplastics trigger oxidative stress, inflammation, and premature cell aging across many experimental models. These are the same biological processes linked to heart disease, brain disorders, and other age-related conditions. Particularly concerning, studies in animals show that plastic-related damage can be passed from parents to offspring, suggesting potential long-term generational health effects.