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Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models
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This review examines what animal and cell studies have revealed about how microplastics and nanoplastics cause harm at the molecular level, including promoting inflammation, oxidative stress, and cell death. Most research has focused on reproductive toxicity and polystyrene particles, while effects on the gut, brain, and heart remain understudied. The authors note that many experiments use unrealistic concentrations and synthetic particles, making it difficult to apply the results to real-world human exposure.
Microplastics (MPs) and nanoplastics (NPs) represent an emerging issue for human and animal health. This review critically examines in vitro and in vivo studies to elucidate their mechanisms of action and toxicological effects. Key objectives included: providing a comprehensive overview of MP-NPs studies in literature, assessing experimental conditions relative to real environmental scenarios, and identifying toxicological pathways at the molecular level. The findings revealed significant progress in understanding MP-NPs impacts. In particular, it has been observed the promotion of inflammation, oxidative stress, apoptosis, autophagy, and endoplasmic reticulum (ER) stress via specific signaling axes. Reproductive toxicity emerged as the primary research focus, particularly in male models, whereas effects on gastrointestinal, neurological, and cardiovascular systems were insufficiently studied, especially for the molecular pathways affected. Most studies disproportionately focused on polystyrene particles, neglecting other prevalent polymers such as polyethylene and polypropylene. Furthermore, reliance on synthetic microspheres and non-realistic experimental concentrations limits relevance to real-world conditions. Limited long-term exposure studies further constrain the understanding of MP-NPs persistence and risks. In view of this, future research should integrate environmentally relevant conditions for particles doses, size and composition, long-term exposure assessments, and advanced methodologies such as omics and computational modeling. In addition, therapeutic interventions targeting oxidative and ER stress, inflammation and apoptosis may be an excellent solution to mitigate MP-NPs toxicity. At the same time, a standardized global approach is needed to fully understand the risks posed by MP-NPs, attempting to safeguard public and environmental health.
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Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects
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This review examines the biological mechanisms by which micro- and nanoplastics may cause harm in humans, including oxidative stress, inflammation, disruption of protective barriers, and immune system problems. Evidence from lab and animal studies suggests these particles can affect the gut, heart, brain, and reproductive systems, though human data is still limited to detecting plastics in tissues rather than proving they cause specific diseases. The authors highlight that most studies use higher doses than people actually encounter, making it important to develop research models that better reflect real-world chronic exposure.
Research progress on the cellular toxicity caused by microplastics and nanoplastics
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This review summarizes current research on how microplastics and nanoplastics cause damage at the cellular level. Researchers identified four main ways these particles harm cells: triggering oxidative stress, damaging cell membranes and organelles, causing inflammation, and disrupting DNA. The findings highlight growing evidence that plastic particles small enough to enter cells can interfere with fundamental biological processes.
Micro- and nanoplastic induced cellular toxicity in mammals: A review
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This review examines research on how micro- and nanoplastics cause cellular damage in mammalian systems, covering both laboratory and animal studies. Evidence indicates that these particles can trigger oxidative stress, inflammation, and DNA damage in cells, with smaller nanoplastics generally showing greater toxicity due to their ability to penetrate cell membranes more readily.
Microplastics and Nanoplastics in Health Concerning Cellular Toxicity Mechanisms, Exposure Pathways, and Global Mitigation Strategies
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This review synthesizes current knowledge on how micro- and nanoplastics cause cellular damage in the human body, covering mechanisms like oxidative stress, inflammation, DNA damage, and disruption of cell signaling pathways. Researchers note that exposure occurs through multiple routes including ingestion and inhalation, allowing particles to reach organs throughout the body. The study highlights significant gaps in understanding long-term and low-dose exposure effects that are most relevant to everyday human contact with these particles.
Micro- and nanoplastics (MNPs) and their potential toxicological outcomes: State of science, knowledge gaps and research needs
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This review summarizes what is known about the toxicity of micro- and nanoplastics in mammals, drawing from both cell studies and animal experiments. Evidence suggests these particles can cause inflammation, oxidative stress, gut disruption, and reproductive harm, with effects depending on particle size, shape, and chemical composition. However, most studies use uniform lab-made particles rather than the irregular plastics humans actually encounter, making real-world risk assessment challenging.
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