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61,005 resultsShowing papers similar to Modification of acetoacetyl-CoA reduction step in Ralstonia eutropha for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from structurally unrelated compounds
ClearDisruption of poly (3-hydroxyalkanoate) depolymerase gene and overexpression of three poly (3-hydroxybutyrate) biosynthetic genes improve poly (3-hydroxybutyrate) production from nitrogen rich medium by Rhodobacter sphaeroides
Bacterial genes were engineered to improve production of PHB, a natural biodegradable plastic substitute, in bacteria that grow without using sugar as a carbon source. More efficient bio-based plastic production could help reduce dependence on petroleum-derived plastics.
Advancements in genetic engineering for enhanced Polyhydroxyalkanoates (PHA) production: a comprehensive review of metabolic pathway manipulation and gene deletion strategies
This review examines genetic engineering strategies for boosting production of polyhydroxyalkanoates, which are biodegradable bioplastics produced by bacteria. Researchers describe how modifying metabolic pathways and deleting competing genes can significantly increase bioplastic yields. The technology is relevant to the microplastics problem because scaling up biodegradable plastic alternatives could help reduce the accumulation of persistent conventional plastics in the environment.
Engineering chimeric polyhydroxyalkanoate synthases for enhanced copolymerization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate): A promising biotechnological approach
Researchers engineered chimeric bacterial enzymes to improve the production of polyhydroxyalkanoates, a class of biodegradable plastics that could serve as sustainable alternatives to conventional plastics. By swapping protein domains between two different PHA synthases, they achieved up to a 200% increase in bioplastic production with better control over polymer composition and granule formation. The approach offers a framework for scaling up production of environmentally friendly plastic alternatives.
Scalable Biosynthesis & Recovery of Poly-3-Hydroxybutyrate Produced from Cotton-Derived Glucose by Ralstonia eutropha
Researchers optimised the biosynthesis and recovery of poly-3-hydroxybutyrate using cotton-derived glucose as a substrate with Ralstonia eutropha, addressing the high production costs that limit large-scale use of this biodegradable biopolymer alternative to petroleum-based plastics.
Comparative Genomics of Marine Bacteria from a Historically Defined Plastic Biodegradation Consortium with the Capacity to Biodegrade Polyhydroxyalkanoates
Researchers conducted comparative genomics of marine bacteria from a plastic biodegradation consortium, finding that multiple strains had the genomic capacity to biodegrade polyhydroxyalkanoate (PHA) bioplastics, with implications for understanding microbial degradation of biodegradable plastic alternatives.
Poly(3-hydroxybutyrate) production by Rhodopseudomonas sp. S16-VOGS3 cells grown in digested sludge
Researchers demonstrated that photosynthetic bacteria can be grown using nutrient-rich wastewater sludge as a low-cost medium, producing a biodegradable plastic called PHB (polyhydroxybutyrate) when phosphate becomes scarce. This approach offers a way to create eco-friendly bioplastics from waste materials, reducing reliance on petroleum-based plastics.
Polyhydroxyalkanoates biosynthesis, resulting polymer structures, and plasticization
This review examines polyhydroxyalkanoates (PHAs), a class of biodegradable biopolymers synthesized by microorganisms, discussing strategies including plasticizers and monomer inclusion to overcome the brittleness and processing challenges of the most common PHA, poly(3-hydroxybutyrate).
Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment
Researchers isolated and characterised Pseudohalocynthiibacter aestuariivivens P96, a marine bacterium from a highly polluted coastal environment, finding it capable of producing poly(3-hydroxybutyrate) (PHB) at up to 4.73 g/L corresponding to 87% of total cell dry weight, representing a promising bio-based and biodegradable alternative to fossil-fuel plastics.
The synthesis of polyhydroxyalkanoates from low carbon wastewater under anaerobic-microaerobic process: effects of pH and nitrogen and phosphorus limitation
Researchers optimized conditions for producing polyhydroxyalkanoates (PHAs) — biodegradable bioplastics — from wastewater using bacteria under anaerobic-microaerobic conditions. Controlling pH and nutrient levels significantly improved PHA production yield. This work advances the development of sustainable plastic alternatives made from waste materials.
RSM–GA Based Optimization of Bacterial PHA Production and In Silico Modulation of Citrate Synthase for Enhancing PHA Production
Researchers optimized bacterial production of polyhydroxyalkanoates (PHAs) — biodegradable bioplastics — using kitchen and agricultural waste as cheap feedstocks. Scaling up PHA production is one strategy for replacing conventional petroleum-based plastics that persist in the environment as microplastics.
The co-conversion of methane and mixtures of volatile fatty acids into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) expands the potential of an integrated biorefinery
Researchers used a methane-consuming bacterium to simultaneously convert natural gas and food waste byproducts into PHBV, a biodegradable plastic alternative, achieving yields that varied depending on the mix of waste acids supplied. This integrated biorefinery approach could reduce reliance on conventional petroleum-based plastics by making biodegradable polymers from waste streams.
Production of polyhydroxyalkanoate (PHA) biopolymer from crop residue using bacteria as an alternative to plastics: a review
This review examines how PHA, a biodegradable plastic made from crop waste using bacteria, could serve as a sustainable alternative to conventional plastics. While PHA breaks down naturally unlike traditional plastics that fragment into microplastics, challenges remain in making it heat-stable and cost-competitive enough for widespread industrial use.
Exploring Microorganisms from Plastic-Polluted Sites: Unveiling Plastic Degradation and PHA Production Potential
Researchers screened microorganisms from plastic-polluted sites for their ability to break down conventional plastics and produce a biodegradable alternative called PHA. They identified several bacterial strains capable of degrading synthetic polymers and simultaneously producing this bio-based plastic from waste materials. The study highlights the potential for using naturally adapted microbes from contaminated environments as tools for both plastic cleanup and sustainable material production.
Bioplastics against Microplastics: Screening of Environmental Bacteria for Bioplastics Production
Researchers screened environmental bacteria for their ability to produce polyhydroxyalkanoate bioplastics, which are biodegradable alternatives to conventional petroleum-based plastics. Developing efficient bioplastic-producing strains is one strategy to reduce the long-term accumulation of persistent microplastics in the environment.
Production of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) by Haloferax mediterranei Using Candy Industry Waste as Raw Materials
Researchers explored using candy industry waste as a low-cost feedstock for the haloarchaeon Haloferax mediterranei to produce PHBV, a biodegradable polymer that could serve as an alternative to conventional plastics. They found that the microorganism could effectively convert sugar-rich waste streams into this bio-based material without requiring expensive precursor chemicals. The study presents a circular economy approach that simultaneously addresses food industry waste and plastic pollution.
The Halophilic Bacterium Paracoccus haeundaensis for the Production of Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) from Single Carbon Sources
This study demonstrated for the first time that Paracoccus haeundaensis can produce polyhydroxyalkanoates (PHAs) under nitrogen-limited conditions with glucose as carbon source, identifying it as a potential new bacterial host for biodegradable plastic production.
Structures of Polyhydroxyalkanoate Synthase PhaC from Aeromonas caviae , Producing Biodegradable Plastics
Researchers solved the crystal structures of polyhydroxyalkanoate synthase PhaC from Aeromonas caviae, providing molecular-level insight into how this bacterial enzyme polymerizes biodegradable PHA plastics, with implications for engineering improved bioplastic production systems.
Study of Bacterial Biopolymer Production by Bacillus Species
This study investigated the ability of Bacillus bacteria to produce polyhydroxyalkanoate (PHA) biopolymers, which are biodegradable alternatives to petroleum-based plastics. Microbial biopolymer production could help reduce reliance on conventional plastics that persist and accumulate in the environment.
Biosynthesis of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from CO2 by a Recombinant Cupriavidusnecator
A recombinant Cupriavidus necator strain was engineered to produce the flexible, marine-biodegradable copolyester PHBHHx from CO2 as the sole carbon source, demonstrating a route to bio-based plastic production that avoids competition with food crops for feedstocks.
Towards synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression
Researchers engineered a soil bacterium to simultaneously break down PET plastic and use its building-block chemicals as food, identifying key bottlenecks in balancing enzyme production with bacterial fitness that will need to be resolved before such microbes can be used for large-scale plastic biodegradation.
Polyhydroxyalkanoate (PHA) Biopolymer Synthesis by Marine Bacteria of the Malaysian Coral Triangle Region and Mining for PHA Synthase Genes
Researchers isolated PHA-producing bacterial strains from marine sponge and sediment samples collected in the Malaysian Coral Triangle, using both cultivation and metagenomic approaches to identify PHA synthase genes, and characterized novel strains capable of producing biodegradable biopolymers as potential alternatives to petroleum-based plastics.
Bioconversion of whey to Polyhydroxyalkanoate (PHA): Process Optimization and Yield Enhancement
Researchers investigated the microbial biosynthesis of polyhydroxyalkanoate using cheese whey as a substrate with a novel Stutzerimonas stutzeri strain, optimising the process to enhance PHA yield as a biodegradable alternative to conventional petroleum-based plastics.
Identification and characterization of a novel extracellular polyhydroxyalkanoate depolymerase in the complete genome sequence of Undibacterium sp. KW1 and YM2 strains
Researchers identified a bacterial enzyme in freshwater Undibacterium species that can degrade polyhydroxyalkanoate (PHA), a type of biodegradable plastic. This discovery is relevant to developing microbially enhanced breakdown of biodegradable plastic alternatives to conventional petroleum-based plastics.
Bacterial Production of Hydroxyalkanoates (PHA)
This review examines bacterial production of polyhydroxyalkanoates (PHA) as a biodegradable alternative to petroleum-based plastics, covering fermentation processes, scaling to industrial levels, and future trends, while noting that higher production costs currently prevent PHAs from competing commercially with conventional plastics.