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Modification of acetoacetyl-CoA reduction step in Ralstonia eutropha for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from structurally unrelated compounds
Summary
Researchers demonstrated that modifying an enzyme pathway in the bacterium Ralstonia eutropha changes the composition of biodegradable plastic (PHA copolyester) it produces. Engineering bacteria to produce specific biodegradable plastic compositions is relevant to creating materials that degrade fully in the environment rather than persisting as microplastics.
The present results indicate the importance of flux distribution at the acetoacetyl-CoA node in R. eutropha for the biosynthesis of the PHA copolyesters with regulated composition from structurally unrelated compounds.
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