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Papers
61,005 resultsShowing papers similar to Fundamental studies on droplet throughput and the analysis of single cells using a downward-pointing ICP-time-of-flight mass spectrometer
ClearCharacterization of a high-sensitivity ICP-TOFMS instrument for microdroplet, nanoparticle, and microplastic analyses
Researchers characterized the capabilities of an ICP time-of-flight mass spectrometry instrument for single-droplet and single-particle analysis, demonstrating its high sensitivity for simultaneously detecting multiple elements in individual microdroplets, nanoparticles, and microplastic particles.
Determination of carbon in microplastics and single cells by total consumption microdroplet ICP-TOFMS
This study developed a total consumption microdroplet ICP-TOFMS method to determine carbon content in microplastics and single cells, overcoming size limitations of conventional nebulization methods. The approach enables more accurate elemental characterization of individual microplastic particles.
Development of microdroplet calibration for the accurate quantification of particles by single-particle ICP-TOFMS
Researchers developed and validated a microdroplet calibration technique for single-particle ICP-TOFMS to improve accuracy and throughput in multi-elemental quantification of nanoparticles and microparticles in complex sample matrices, achieving single-digit attogram detection limits for many elements.
Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events
This review describes how time-resolved ICP-MS analysis has transformed the technique from bulk elemental analysis into a tool for characterizing individual nanoparticles and single cells, enabling detection and characterization of nanoplastics and other nano-objects in complex samples.
Single-Particle ICP-TOFMS with Online Microdroplet Calibration: A Versatile Approach for Accurate Quantification of Nanoparticles, Submicron Particles, and Microplastics in Seawater
Online microdroplet calibration was used with single-particle ICP-TOFMS to overcome matrix effects and achieve accurate multi-element quantification in nanoparticle and microparticle samples, demonstrating a versatile approach for environmental and industrial nanoparticle analysis.
Facets of ICP-MS and their potential in the medical sciences—Part 2: nanomedicine, immunochemistry, mass cytometry, and bioassays
Researchers review how inductively coupled plasma mass spectrometry (ICP-MS), a technique that measures trace elements in biological samples, has expanded into medical fields like nanomedicine, cancer diagnostics, and disease biomarker detection. This powerful analytical tool is enabling personalized medicine by allowing scientists to simultaneously analyze both elements and biomolecules at very low concentrations.
Development of single-cell ICP-TOFMS to measure nanoplastics association with human cells
Researchers developed a new single-cell analytical technique using ICP-TOFMS to measure how nanoplastic particles associate with individual human cells. This method enables detection of nanoplastics at the single-cell level, offering a more precise way to study how these tiny plastic particles interact with human tissues. The approach addresses a critical gap in understanding nanoplastic exposure and uptake in biological systems.
Expanding the boundaries of atomic spectroscopy at the single-cell level: critical review of SP-ICP-MS, LIBS and LA-ICP-MS advances for the elemental analysis of tissues and single cells
Researchers reviewed three advanced atomic measurement techniques — SP-ICP-MS, LIBS, and LA-ICP-MS — that can detect and map metals inside individual cells with extreme precision. These tools are increasingly important for understanding how toxic metals from pollution, including those leached by microplastics, distribute within biological tissues and affect disease.
Investigating the Cellular Uptake of Model Nanoplastics by Single-Cell ICP-MS
Researchers developed gold-doped polyethylene and polyvinyl chloride nanoparticles as model nanoplastics and used single-cell ICP-MS to investigate their cellular uptake. The study demonstrated that this approach enables rapid, high-throughput detection of nanoplastic interactions with cells, providing a valuable tool for understanding how environmentally relevant nanoplastics behave at the cellular level.
Optofluidic Force Induction meets Raman Spectroscopy and Inductively Coupled Plasma – Mass Spectrometry: A new hyphenated technique for comprehensive and complementary characterisations of single particles
Optofluidic force induction was combined with Raman spectroscopy and ICP-MS to characterize nanoparticle size distributions, elemental compositions, and concentrations, demonstrating a multi-modal analytical approach for comprehensive nanoparticle characterization in environmental and industrial contexts.
Catching particles by atomic spectrometry: Benefits and limitations of single particle - inductively coupled plasma mass spectrometry
This review evaluates single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS) as an analytical technique, highlighting its expanding capabilities for detecting, sizing, and quantifying metal-based nanoparticles and emerging applications in microplastic and carbon-based particle analysis.
Trends and Advances in Inductively Coupled Plasma Tandem Quadruple Mass Spectrometry (ICP-QMS/QMS) With Reaction Cell
This review summarized advances in inductively coupled plasma tandem quadrupole mass spectrometry (ICP-QMS/QMS) from 2018-2021, highlighting its expanding applications in environmental, food, biological, and material sciences including single-particle analysis of nanoplastics and trace element speciation.
Critical evaluation of the potential of ICP-MS-based systems in toxicological studies of metallic nanoparticles
This review evaluates advanced mass spectrometry techniques for studying how metallic nanoparticles behave in biological systems, including how they enter cells, where they accumulate, and how they transform inside the body. While focused on metal nanoparticles rather than microplastics, many of the same analytical methods are being applied to track nanoplastics in tissues. Better tools for detecting and measuring tiny particles in the body are essential for understanding the real health impacts of nanoplastic exposure.
Quantitative sizing of microplastics up to 20 µm using ICP-TOFMS
Researchers tested new ways to measure the size of individual microplastic particles using a specialized mass spectrometry technique (ICP-TOFMS). By modifying the sample introduction system, they extended the upper size limit for detection from 10 micrometers to 20 micrometers. The study demonstrates that instrument configuration significantly affects the ability to accurately size and count microplastic particles in liquid samples.
Label-free droplet image analysis with Cellprofiler
Researchers developed a label-free droplet image analysis workflow using CellProfiler to enable high-throughput processing of droplet microfluidics images without requiring molecular labels or expensive proprietary software. The approach makes droplet microfluidic technology more accessible for a broader range of biological and microbiological applications.
Detection and characterization of secondary micro- and nanoplastics after aging using single particle ICP-MS and OF2i
Researchers combined single-particle ICP-MS and optofluidic force induction Raman spectroscopy to detect and characterize secondary micro- and nanoplastics generated during aging of larger plastic fragments, demonstrating that the combined approach can analyze particles across a wide size range.
Rapid Single Particle Atmospheric Solids Analysis Probe-Mass Spectrometry for Multimodal Analysis of Microplastics
Researchers developed an atmospheric solid analysis probe coupled to mass spectrometry for rapid chemical characterization of single microplastic particles, enabling polymer identification while remaining compatible with complementary imaging techniques for comprehensive microplastic analysis.
Introducing “time-of-flight single particle investigator” (TOF-SPI): a tool for quantitative spICP-TOFMS data analysis
Researchers developed a new software tool called TOF-SPI for analyzing single-particle data from a mass spectrometry technique used to characterize tiny particles in environmental samples. The software provides accurate, high-throughput processing of particle composition data. The tool is designed to help scientists more efficiently identify and quantify nanoparticles and microplastics in complex samples.
Optofluidic Force Induction Meets Raman Spectroscopy and Inductively Coupled Plasma-Mass Spectrometry: A New Hyphenated Technique for Comprehensive and Complementary Characterizations of Single Particles
Researchers developed a new analytical technique that combines optical trapping, Raman spectroscopy, and mass spectrometry to characterize individual nanoparticles in a single measurement. The method can identify the chemical composition, elemental makeup, and size of particles one at a time. While demonstrated on engineered nanoparticles, this technology could eventually be applied to detect and characterize individual nanoplastic particles in environmental and biological samples.
Single-particle isotope ratio analysis of lanthanide-doped microplastics using inductively coupled plasma time-of-flight mass spectrometry
Inductively coupled plasma time-of-flight mass spectrometry (ICP-TOF-MS) with collision cell technology was optimized for single-particle isotope ratio analysis of lanthanide-doped microplastics, achieving improved accuracy and precision—enabling tracer-based tracking of individual microplastic particles in environmental samples.
Characterisation of microplastics and unicellular algae in seawater by targeting carbon via single particle and single cell ICP-MS
Researchers used single particle and single cell ICP-MS to characterize microplastics and microalgae simultaneously in seawater by targeting carbon signals, demonstrating the technique as a rapid and sensitive tool for distinguishing plastic particles from biological material.
Detection of microplastics using inductively coupled plasma-mass spectrometry (ICP-MS) operated in single-event mode
Researchers tested whether inductively coupled plasma-mass spectrometry (ICP-MS) operated in single-event mode could detect microplastics by identifying their trace metal signatures, offering a novel analytical approach. This method could complement existing optical techniques for detecting microplastics in complex environmental samples.
Droplet-Based Technology for Studying the Phenotypic Effect of Microplastics on Antimicrobial Resistance
This study used droplet-based microfluidic technology to investigate the phenotypic effects of microplastics on individual cells or organisms at high throughput. Droplet microfluidics enables rapid screening of how different microplastic concentrations and types affect biological responses at the cellular level.
ICP-MS-Based Characterization and Quantification of Nano- and Microstructures
Researchers developed ICP-MS-based methods for characterizing and quantifying both nano- and microstructures in environmental and biological samples, evaluating the capability of single-particle ICP-MS and bulk analysis to distinguish particle populations by size, elemental composition, and number concentration. The methodology demonstrated detection of particles down to the low nanometer size range in complex matrices.