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61,005 resultsShowing papers similar to Single and combined acute and subchronic toxic effects of microplastics and copper in zebrafish (Danio rerio) early life stages
ClearToxicological effects induced on early life stages of zebrafish (Danio rerio) after an acute exposure to microplastics alone or co-exposed with copper
Researchers exposed zebrafish embryos to microplastics alone and combined with copper to assess their joint toxicity during early development. They found that copper, both alone and combined with microplastics, reduced survival, increased oxidative stress, inhibited a key nervous system enzyme, and disrupted avoidance and social behaviors. The study suggests that microplastics may modulate copper toxicity in some biological endpoints, highlighting the importance of studying combined pollutant exposures during vulnerable developmental stages.
Polystyrene microplastics (PS-MPs) harness copper presence and promote impairments in early zebrafish (Danio rerio) larvae: Developmental, biochemical, transcriptomic approaches and nontargeted metabolomics approaches
This zebrafish study found that polystyrene microplastics combined with copper produced worse toxic effects than either pollutant alone, causing developmental problems, oxidative stress, immune disruption, and nerve damage in larvae. The combination also disrupted the fish's metabolism in ways that neither pollutant caused independently. This is concerning because microplastics readily absorb heavy metals like copper in the environment, meaning organisms are often exposed to both together.
Combined effects of microplastics and copper on oxidative responses in zebrafish (Danio rerio)
Researchers exposed zebrafish (Danio rerio) to microplastics (10 µg/L) and copper (45 µg/L) individually and in combination, finding that fish exposed to both stressors simultaneously exhibited higher oxidative stress across multiple body organs than those exposed to either contaminant alone.
Microplastics alone or co-exposed with copper induce neurotoxicity and behavioral alterations on zebrafish larvae after a subchronic exposure
Researchers exposed zebrafish larvae to microplastics alone and in combination with copper, a common water pollutant, and found that both caused neurotoxic effects and behavioral changes. Larvae showed reduced swimming speed, impaired avoidance responses, and inhibited activity of acetylcholinesterase, a key enzyme for nervous system function. When microplastics and copper were combined, the harmful effects were amplified, suggesting that microplastics can worsen the toxicity of other environmental contaminants.
Long-term effects of individual and combined exposure to microplastics and copper in zebrafish hypothalamic-pituitary-gonadal axis – A multi-biomarker evaluation
This study exposed zebrafish to microplastics, copper, and both combined for 30 days and examined effects on their reproductive system. The combination of microplastics and copper caused greater hormonal disruption and oxidative stress than either pollutant alone, affecting genes that control reproduction in both male and female fish. These findings suggest that microplastics interacting with metal pollution in waterways could compound reproductive harm in aquatic organisms and potentially in humans who consume contaminated fish.
The impact of microplastics and copper on sex ratio and oxidative stress: analysis in zebrafish intestine, gonad and brain
Researchers exposed zebrafish embryos to copper, polyethylene, and polystyrene microplastics individually and in combination, finding that copper caused high mortality, PE alone induced a feminization trend, and co-exposure amplified adverse effects on sex differentiation and antioxidant enzyme activity.
Impact and Molecular Mechanism of Microplastics on Zebrafish in the Presence and Absence of Copper Nanoparticles
Polystyrene microplastics of three sizes combined with copper nanoparticles caused additive or synergistic toxicity in zebrafish, disrupting oxidative stress responses, gene expression, and early development, with 0.07-micrometer particles producing the most severe effects.
Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish
Researchers exposed adult zebrafish to polyethylene microplastics and cadmium, both individually and in combination, for 21 days. They found that microplastics and cadmium together produced additive toxic effects, increasing cadmium accumulation in fish tissues, altering behavior, and causing more severe organ damage. The study suggests that microplastics in contaminated waterways may worsen the harmful effects of heavy metals on aquatic life.
Toxicity of microplastics and copper, alone or combined, in blackspot seabream (Pagellus bogaraveo) larvae
Researchers examined the toxicity of microplastics and copper, alone and combined, on blackspot seabream larvae, finding that microplastic-copper mixtures can alter biochemical biomarkers and gene expression related to oxidative stress and immune response in developing fish.
Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics combined with cadmium for three weeks and found that the presence of microplastics significantly increased cadmium accumulation in the liver, gut, and gills. The combined exposure caused greater oxidative damage, tissue inflammation, and disruption of protective gene activity than either pollutant alone. The study demonstrates that microplastics can enhance the toxicity of heavy metals in fish by acting as carriers that increase the body's uptake of harmful substances.
Microplastics- and copper-induced changes in neurogenesis and DNA methyltransferases in the early life stages of zebrafish
Researchers found that exposure to microplastics and copper, alone or combined, disrupted neurogenesis and DNA methylation in zebrafish embryos, downregulating genes involved in neuronal development and suggesting epigenetic mechanisms underlying neurotoxicity.
Combined toxicity of microplastics and cadmium on the zebrafish embryos (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene microplastics combined with cadmium to assess their combined toxic effects on aquatic organisms. The study found that co-exposure produced greater negative impacts on survival and heart rate than either pollutant alone, with toxicity increasing in a concentration-dependent manner.
The Effects of Single and Combined Exposure to Polystyrene Nanoplastics and Copper on the Behavior of Adult Zebrafish
Researchers studied how polystyrene nanoplastics and copper ions affected zebrafish behavior when the fish were exposed to both pollutants simultaneously. The combination was more toxic than either pollutant alone, reducing the concentration needed to kill fish by up to 32%. Since nanoplastics and heavy metals commonly occur together in polluted water, their combined effects on aquatic life could increase the risks associated with consuming contaminated fish.
Microplastics and copper induce apoptosis, alter neurocircuits, and cause behavioral changes in zebrafish (Danio rerio) brain
Researchers investigated the chronic effects of microplastics and copper, alone and combined, on zebrafish brains over 30 days. The study found that both contaminants induced apoptosis, altered neurotransmitter pathways, and caused behavioral changes including increased anxiety, with combined exposure producing more severe effects than either pollutant alone.
Microplastics aggravate the adverse effects of methylmercury than inorganic mercury on zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene microplastics combined with two forms of mercury and found that the microplastics significantly increased the accumulation of methylmercury in the fish. The combination of microplastics and methylmercury caused worse developmental abnormalities, delayed hatching, and greater oxidative stress than either pollutant alone. The study suggests that microplastics can act as carriers for toxic metals, amplifying their harmful effects on aquatic organisms.
Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish
Researchers investigated the combined effects of polystyrene microplastics and natural organic matter on copper accumulation and toxicity in zebrafish. They found that microplastics increased copper accumulation in the liver and gut, and that natural organic matter further amplified this effect in a size-dependent manner. The study suggests that microplastics in natural waters can interact with dissolved organic matter and metals to create more harmful exposure conditions for aquatic organisms.
Mitochondrial dysfunction and lipometabolic disturbance induced by the co-effect of polystyrene nanoplastics and copper impede early life stage development of zebrafish (Danio rerio)
Researchers found that co-exposure to polystyrene nanoplastics and copper at environmentally relevant concentrations caused mitochondrial dysfunction and lipid metabolism disruption in zebrafish embryos, impairing early development and survival more severely than either contaminant alone.
Combined effects of microplastics and chemical contaminants on the organ toxicity of zebrafish ( Danio rerio )
Researchers studied the combined effects of microplastics and chemical contaminants like PCBs and methylmercury on zebrafish organs over three weeks of exposure. They found that microplastics carrying adsorbed contaminants produced the most significant effects, particularly on the liver, compared to either microplastics or contaminants alone. The results indicate that microplastics may act as carriers that increase the delivery of harmful chemicals to organisms' tissues.
Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure
Researchers investigated how PVC microplastics interact with copper exposure in common carp over 14 days. They found that the microplastic particles acted as a vector for copper, increasing its accumulation in the liver and worsening tissue damage beyond what either pollutant caused alone. The study suggests that microplastics can amplify the toxic effects of heavy metals in freshwater fish.
Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)
Researchers examined the combined effects of polystyrene microplastics and copper on Nile tilapia and found that co-exposure increased copper accumulation in the liver and caused tissue damage in multiple organs. High concentrations of both contaminants together triggered oxidative stress, inflammation, and shifts in intestinal microbial communities. The study suggests that microplastics can worsen the toxic effects of heavy metals on freshwater fish.
Microplastics and Copper Affect Zebrafish Behavior and Responses to Predation Threat
Zebrafish were exposed to two size classes of aged polyethylene microplastics with and without copper (10 µg/L) to assess effects on behaviour and predator response. Microplastics and copper together impaired anti-predator behaviour more than either pollutant alone, suggesting synergistic impacts on fish survival in contaminated environments.
Combined effects of polystyrene microplastics and cadmium on oxidative stress, apoptosis, and GH/IGF axis in zebrafish early life stages
Researchers exposed zebrafish embryos to polystyrene microplastics and cadmium, both alone and together, and found that the combination caused significantly worse effects than either pollutant individually. Co-exposure amplified oxidative stress, increased cell death in the spine and esophagus, and disrupted growth hormone pathways more severely than single exposures. The findings suggest that microplastics and heavy metals in waterways may interact to create heightened risks for developing fish.
Biochemical impacts of PET microplastics and cadmium on Danio rerio under environmental conditions
This study examined the combined biochemical effects of PET microplastics and cadmium on zebrafish under environmentally relevant exposures, finding that co-exposure altered oxidative stress biomarkers, liver enzyme activity, and immune responses in ways that differed from single-contaminant exposures.
Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
Researchers studied the combined toxic effects of polystyrene microplastics and cadmium at different concentrations in zebrafish over a 10-day exposure period. The study found that microplastics could either amplify or reduce cadmium toxicity depending on the metal concentration, affecting survival, growth, and antioxidant responses in complex ways.