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Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish
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Researchers investigated the combined effects of polystyrene microplastics and natural organic matter on copper accumulation and toxicity in zebrafish. They found that microplastics increased copper accumulation in the liver and gut, and that natural organic matter further amplified this effect in a size-dependent manner. The study suggests that microplastics in natural waters can interact with dissolved organic matter and metals to create more harmful exposure conditions for aquatic organisms.
As emerging contaminants, microplastics (MPs) are predicted to act as vectors for other contaminants and their combined effects are largely unknown. In this study, the combined effects of MPs and natural organic matter (NOM) on the accumulation and toxicity of copper (Cu) in zebrafish (Danio rerio) were investigated. As a result, small-size MPs could absorb more Cu than large-size MPs. The presence of NOM promoted Cu adsorption on MPs in the pH range of 6-8. Our results demonstrate that the combination of MPs and NOM increased Cu accumulation in the livers and guts in a size-depended manner. Correspondingly, the results of biochemical test showed that MPs and NOM could aggravate Cu-toxicity in the livers and guts, which is manifested in the increased levels of malonaldehyde (MDA) and metallothionein (MT) and decreased levels of superoxide dismutase (SOD). Furthermore, the results of transcriptomic analysis suggested that such aggravation of toxicity was mainly attributed to the inhibition of Cu-ion transport and the enhanced oxidative stress. Since the co-existence of MPs and NOM in the environment is inevitable, their enhancement effects on the bioaccumulation and toxicity of other pollutants such as heavy metals deserve more attention.
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Researchers examined the combined effects of polystyrene microplastics and copper on Nile tilapia and found that co-exposure increased copper accumulation in the liver and caused tissue damage in multiple organs. High concentrations of both contaminants together triggered oxidative stress, inflammation, and shifts in intestinal microbial communities. The study suggests that microplastics can worsen the toxic effects of heavy metals on freshwater fish.
Polystyrene microplastics (PS-MPs) harness copper presence and promote impairments in early zebrafish (Danio rerio) larvae: Developmental, biochemical, transcriptomic approaches and nontargeted metabolomics approaches
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This zebrafish study found that polystyrene microplastics combined with copper produced worse toxic effects than either pollutant alone, causing developmental problems, oxidative stress, immune disruption, and nerve damage in larvae. The combination also disrupted the fish's metabolism in ways that neither pollutant caused independently. This is concerning because microplastics readily absorb heavy metals like copper in the environment, meaning organisms are often exposed to both together.
Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish
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Researchers exposed adult zebrafish to polyethylene microplastics and cadmium, both individually and in combination, for 21 days. They found that microplastics and cadmium together produced additive toxic effects, increasing cadmium accumulation in fish tissues, altering behavior, and causing more severe organ damage. The study suggests that microplastics in contaminated waterways may worsen the harmful effects of heavy metals on aquatic life.
Single and combined acute and subchronic toxic effects of microplastics and copper in zebrafish (Danio rerio) early life stages
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Researchers exposed zebrafish embryos and larvae to microplastics, copper, and their combinations to assess individual and combined toxic effects. They found that microplastics alone caused limited harm, but when combined with copper, the mixture produced altered biochemical responses and changes in gene expression. The study suggests that microplastics can modify the toxicity of heavy metals in aquatic organisms during early development.
Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio)
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Researchers exposed zebrafish to polystyrene microplastics combined with cadmium for three weeks and found that the presence of microplastics significantly increased cadmium accumulation in the liver, gut, and gills. The combined exposure caused greater oxidative damage, tissue inflammation, and disruption of protective gene activity than either pollutant alone. The study demonstrates that microplastics can enhance the toxicity of heavy metals in fish by acting as carriers that increase the body's uptake of harmful substances.
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