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61,005 resultsShowing papers similar to The Histopathological and Genetic Effects of Long-Term Treatment with High-Molecular-Weight Polyvinyl Chloride on Various Organs of Young Wistar Rats
ClearIntestinal effects of ingested PVC microplastic in Wistar rats
Researchers fed Wistar rats PVC microplastics and assessed intestinal effects including permeability, colonic morphology, and inflammatory markers. The findings showed that ingested PVC microplastics caused measurable changes in gut integrity and inflammation, contributing evidence for gastrointestinal toxicity.
Dose‐Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
Researchers fed rats PVC and polystyrene microplastics at different doses for eight weeks and observed significant changes including weight loss, elevated blood glucose, increased cholesterol and liver enzymes, and signs of oxidative stress. The study suggests that oral microplastic exposure at these levels can cause dose-dependent toxicological effects across multiple organ systems in mammals.
Kidney and Liver Disorders Due to Microplastic Exposure: Chronic in Vivo Study in Male White Rats
Male white rats were chronically exposed to microplastics (particles 5 mm or smaller) to assess kidney and liver toxicity, with exposure resulting from environmental weathering and ultraviolet irradiation of plastic materials. The study found measurable histopathological and biochemical damage in both organs, confirming that long-term microplastic exposure causes organ-level injury in mammals.
Exposure to High-molecular-weight Polyvinyl Chloride Alters Bacterial Diversity in the Gut Microbiota of the Wistar Rat
Researchers exposed Wistar rats to high-molecular-weight polyvinyl chloride microplastics through their diet and measured changes in gut microbiota diversity and composition. PVC microplastic ingestion significantly altered bacterial diversity in the gut microbiome, supporting the hypothesis that microplastic exposure can disrupt intestinal microbial ecology with potential consequences for host health.
Polyvinyl Chloride Exposure Induces Liver Injury: A Biochemical and Histological Evaluation
This rat study evaluated liver toxicity from 42 days of daily oral polyvinyl chloride administration at doses of 0.1, 0.2, and 0.3 mg/kg. Liver enzymes (AST, ALT, ALP) were elevated disproportionately, oxidative stress markers were disrupted, and histological changes were observed, suggesting dose-dependent hepatotoxicity from PVC microplastics.
In vivo test of acute exposure of polyethylene microplastics on kidney and liver of Rattus norvegicus Wistar strain rats
Researchers exposed male rats to a single dose of polyethylene microplastics and monitored them for 14 days, finding significant changes in body weight, elevated markers of kidney and liver stress in blood tests, and visible tissue abnormalities under microscopy. The results indicate that even short-term, high-dose microplastic exposure can cause measurable organ damage in mammals.
Manifestation of polystyrene microplastic accumulation in tissues of vital organs including brain with histological and behaviour analysis on Swiss albino mice
Researchers exposed rats to polystyrene microplastics and examined accumulation in vital organs including the brain, liver, kidney, and gut, finding tissue-specific deposition that was associated with behavioral changes and organ-level pathological effects.
Avaliação de danos genotóxicos, estresse oxidativo e alterações histopatológicas em robalos juvenis (Centropomus undecimalis) expostos à dieta contendo pó de policloreto de vinila (PVC)
This Brazilian study fed juvenile snook fish a diet containing PVC powder to evaluate genotoxicity, oxidative stress, and tissue damage, finding significant harmful effects including DNA damage and organ pathology. The results indicate that PVC microplastic ingestion causes serious biological harm in fish that are commercially important for human consumption.
Exposure of Cyprinus carpio var. larvae to PVC microplastics reveals significant immunological alterations and irreversible histological organ damage
Researchers conducted a 60-day feeding experiment exposing carp larvae to PVC microplastics at varying concentrations and found significant immune system disruption and organ damage. The microplastics caused liver vacuolation, intestinal villi damage, spleen inflammation, and kidney degeneration, along with elevated inflammatory markers and reactive oxygen species. The findings indicate that chronic dietary exposure to PVC microplastics can cause serious and potentially irreversible harm to freshwater fish immune function.
The Effect of Peroral Polyvinyl Chloride Microplastic on the Value of Prothrombin Time and Activated Partial Thromboplastin Time in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats given 0.5 mg/day of PVC microplastics orally exhibited altered prothrombin time and activated partial thromboplastin time values compared to controls, suggesting that microplastic accumulation in the liver impairs hepatocyte synthesis of blood clotting factors.
Effect of Microplastic Intake on Intestinal and Pancreatic Cell Damage
Researchers investigated the effects of oral microplastic administration on the intestinal and pancreatic cells of Rattus norvegicus Wistar rats to assess organ-level damage from ingestion via contaminated food and drink. Using a quantitative experimental design, they found that oral microplastic intake impairs the function of the small intestine, large intestine, and pancreas, providing experimental evidence for cellular damage in key digestive and endocrine organs following microplastic ingestion.
Exploring the Impacts of Polyethylene Microplastics on Rat Liver
Wistar rats exposed to polyethylene microplastics at 0.1–5 mg/kg for 4 weeks showed dose-dependent PE accumulation in liver tissue confirmed by fluorescence microscopy, with histopathological signs of liver injury despite no significant change in body weight.
Histologic Assessment of Polyvinyl Chloride on the Uterus of Adult Wistar Rats
Researchers administered polyvinyl chloride (PVC) microplastics orally to female Wistar rats at different doses for 21 days and examined uterine tissue. Histological examination revealed distorted uterine architecture across all PVC-treated groups, suggesting that microplastic exposure may have implications for reproductive health.
Histologic Assessment of Polyvinyl Chloride on the Uterus of Adult Wistar Rats
Researchers administered polyvinyl chloride (PVC) microplastics orally to female Wistar rats at different doses for 21 days and examined uterine tissue. Histological examination revealed distorted uterine architecture across all PVC-treated groups, suggesting that microplastic exposure may have implications for reproductive health.
Morphological features of the internal organs in mice after prolonged microplastics consumption
Researchers fed mice polystyrene microplastics at three dose levels for four weeks and found dose-dependent morphological changes restricted to the spleen and colon, including inflammatory infiltration and alterations in mucin-secreting goblet cells, while other organs showed no significant pathological changes.
Distribution and toxicity of submicron plastic particles in mice
Researchers found that orally administered submicron-sized microplastics distributed to multiple organs and biofluids in mice over four weeks, causing oxidative stress and inflammation in tissues including the liver, kidneys, and gut.
Sub-chronic oral exposure to PET nanoplastics: Histopathological effects on ileum, liver, and kidney
Researchers exposed rats to PET nanoplastics orally over a sub-chronic period and assessed histopathological changes in the ileum and other tissues. PET nanoplastics caused structural damage to intestinal tissue at doses relevant to human dietary exposure scenarios.
Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: The insights in physiological, histological, and oxidative damages
Researchers gave mice nanoplastics at doses estimated to match real-world human exposure levels and found the particles crossed the intestinal barrier and accumulated in the liver and kidneys. Even at these low, environmentally relevant doses, the nanoplastics caused oxidative stress and tissue damage across multiple organs. The findings suggest that everyday nanoplastic exposure may pose broader health risks than previously assumed.
Histologic Assessment of Polyvinyl Chloride on the Uterus of Adult Wistar Rats
Researchers administered polyvinyl chloride microplastics orally to adult female rats for 21 days and examined the effects on uterine tissue. Histological examination revealed distorted uterine architecture across all PVC-treated groups compared to controls. The findings suggest that PVC microplastic exposure may negatively impact reproductive organ structure, raising concerns about potential fertility implications from prolonged exposure.
The effect of polystyrene foam in different doses on the blood parameters and relative mass of internal organs of white mice
Researchers fed white mice different doses of polystyrene foam over 42 days and found dose-dependent changes in blood biochemical parameters and relative organ masses, providing evidence that ingested microplastics affect metabolism and internal organ function in mammals.
Ingestion of Polyvinylchloride Powder Particles Induces Oxidative Stress and Hepatic Histopathological Changes in Oreochromis niloticus (Nile Tilapia)—A Preliminary Study
Researchers found that oral exposure to PVC microplastic powder induced oxidative stress and liver histopathological changes in Nile tilapia, with altered water quality parameters and tissue damage indicating significant toxicological effects from ingested plastic particles.
Polyvinyl chloride microplastics induced gut barrier dysfunction, microbiota dysbiosis and metabolism disorder in adult mice
Researchers exposed adult mice to PVC microplastics for 60 days and observed significant damage to the intestinal barrier, including reduced mucus production and increased gut permeability. The exposure also caused notable shifts in gut bacteria composition and altered metabolic profiles in ways associated with intestinal injury. These findings suggest that chronic microplastic ingestion may disrupt gut health by weakening the intestinal lining and changing the microbiome.
The Protective Effect of Pumpkin Extract on Polyvinylchloride) PVC( Hepatotoxicity in Male Albino Rats
This study investigated whether pumpkin extract could protect against liver damage caused by polyvinyl chloride (PVC) microplastics in male albino rats, given that PVC is a common and persistent source of microplastic exposure. Results suggested that pumpkin extract offered a protective effect against PVC-induced hepatotoxicity.
The Effect of Peroral Polyvinyl Chloride Microplastic on Alkaline Phosphatase and Gamma-glutamyl Transferase Levels in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats administered 0.5 mg/day of polyvinyl chloride microplastics orally showed altered alkaline phosphatase and gamma-glutamyl transferase levels compared to controls, providing experimental evidence that oral PVC microplastic exposure can disrupt liver enzyme function.