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Sub-chronic oral exposure to PET nanoplastics: Histopathological effects on ileum, liver, and kidney
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Researchers exposed rats to PET nanoplastics orally over a sub-chronic period and assessed histopathological changes in the ileum and other tissues. PET nanoplastics caused structural damage to intestinal tissue at doses relevant to human dietary exposure scenarios.
Polyethylene terephthalate (PET) plastics are widely used synthetic polymers in packaging for water, fruit juices, and soft drinks. During the production and use of these plastics, microplastics (MPs) and nanoplastics (NPs) are releasing, contributing to PET plastics becoming a prevalent nanopollutant, posing significant concerns for both the environment and human health. This study aimed to investigate the effects of orally administered PET nanoplastics on the ileum, liver, and kidney. For this purpose, PET nanoplastics with a diameter of 56 nm were produced using the dilution-precipitation technique and administered to mice orally at the doses of 0, 0.1, and 0.5 mg/day for 28 days. Following sub-chronic exposure of PET-NPs, organ indexes were calculated and histopathological analysis were performed. Our data revealed that sub-chronic exposure to PET-NPs did not significantly affect liver, kidney or ileum indexes compared to the control group (p¿0.05). Histopathological damage caused by PET nanoplastics was significantly higher in all examined tissues compared to that of in the control group (p Also see: https://micro2024.sciencesconf.org/558673/document
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Sub-chronic oral exposure to PET nanoplastics: Histopathological effects on ileum, liver, and kidney
AI summary Read the abstract
Researchers conducted a sub-chronic oral exposure study in rats using PET nanoplastics, examining histopathological changes in the ileum and other intestinal tissues. PET nanoplastic exposure caused significant structural damage to the intestinal lining at doses relevant to estimated human dietary exposure.
50 Chronic PET nanoplastics ingestion triggers genotoxic and immune responses disrupting gut and systemic homeostasis
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Researchers orally dosed mice with bottle-derived PET nanoplastics and tracked gut and systemic responses over 28 days, finding dose-dependent DNA damage and inflammatory signaling in the jejunum and distal colon, immune suppression in lymph nodes at high doses, and evidence of epithelial reinforcement as the gut adapted to persistent nanoplastic exposure.
Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: The insights in physiological, histological, and oxidative damages
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Researchers gave mice nanoplastics at doses estimated to match real-world human exposure levels and found the particles crossed the intestinal barrier and accumulated in the liver and kidneys. Even at these low, environmentally relevant doses, the nanoplastics caused oxidative stress and tissue damage across multiple organs. The findings suggest that everyday nanoplastic exposure may pose broader health risks than previously assumed.
Potential risks of PET micro- and nanoplastics to the human gastrointestinal system
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Researchers exposed Caco-2 and HepG2 gastrointestinal cell lines to PET micro- and nanoplastics (50 nm to 2 mm) at concentrations from 0.001 to 100 mg/mL for up to 24 hours, assessing effects on gastrointestinal barrier integrity, cell viability, and inflammatory responses. Short-term exposure up to 4 hours did not affect barrier integrity, while longer exposures at higher concentrations began to reveal effects, with PET particles characterized by FTIR, Raman, SEM, and dynamic light scattering showing irregular morphology and elevated electrical charge.
The Histopathological and Genetic Effects of Long-Term Treatment with High-Molecular-Weight Polyvinyl Chloride on Various Organs of Young Wistar Rats
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Researchers fed young Wistar rats food containing 1% or 2% polyvinyl chloride for eight weeks, finding histopathological damage to the intestines, liver, kidney, and spleen, along with genetic effects including DNA fragmentation, demonstrating organ-level toxicity of chronic PVC microplastic ingestion.
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