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Intestinal effects of ingested PVC microplastic in Wistar rats
Summary
Researchers fed Wistar rats PVC microplastics and assessed intestinal effects including permeability, colonic morphology, and inflammatory markers. The findings showed that ingested PVC microplastics caused measurable changes in gut integrity and inflammation, contributing evidence for gastrointestinal toxicity.
Plastic has become a global environmental threat due to its irresponsible use and inadequate waste management, which has eventually led to the accumulation of microplastic in terrestrial and aquatic environments. Microplastics are now a growing concern for their impact on the ecosystem as well as human health. Humans are exposed to microplastic daily, mainly through ingestion and inhalation. With the ingestion of contaminated food and drinks or release of microplastic from food contact materials believed to be the main exposure route. This study aims to investigate the effects of ingested polyvinyl chloride (PVC) microplastic on animals’ overall wellbeing, intestinal permeability and colonic gene expression in Wistar rats.