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Histologic Assessment of Polyvinyl Chloride on the Uterus of Adult Wistar Rats

International Journal of Pharmaceutical and Bio-Medical Science 2026 Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

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Summary

Researchers administered polyvinyl chloride microplastics orally to adult female rats for 21 days and examined the effects on uterine tissue. Histological examination revealed distorted uterine architecture across all PVC-treated groups compared to controls. The findings suggest that PVC microplastic exposure may negatively impact reproductive organ structure, raising concerns about potential fertility implications from prolonged exposure.

Polymers

PVC

Body Systems

Reproductive

Models

Rat

Backgrounds: Polyvinyl chloride (PVC), has emerged as a significant environmental concern with potential impacts on reproductive health. The uterus, a critical organ for female fertility and embryo development, may be vulnerable to microplastic exposure. This study investigated the histological effects of orally administered PVC microplastics on the uterus of adult Wistar rats. Methods: Fifteen adult female Wistar rats (150-200g) were randomly divided into five groups: A: control group, B: negative control group receiving cyclohexanone at 0.1 mg/kg, and C, D and E: Test groups receiving PVC at 0.1, 0.2, and 0.3 mg/kg. Animals were euthanized after 21 days of administration. Uterine tissues were harvested, fixed immediately in 10% formal saline and processed under a histological procedure. Results: Histological examination revealed distorted uterine architecture across all PVC-treated groups. Conclusion: Findings from the current study, showed that PVC-MPs impacted the histoarchitecture of the uterus and prolong and daily exposure can initiate fertility issue in the future, thereby preventing pregnancy in its totality.

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