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Papers
61,005 resultsShowing papers similar to Nanoparticle-Based Delivery Systems for Vaccines
ClearCharacterization of nanoparticles-based vaccines for COVID-19
Researchers reviewed characterization strategies for nanoparticle-based COVID-19 vaccines, arguing that physicochemical, immunological, and toxicological assays must be combined to adequately assess nanovaccine safety and efficacy, and that rigorous characterization frameworks will be essential for navigating regulatory approval of current and future nanoparticle vaccine platforms.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
An Overview of Nanoparticle Properties and Their Bioactivity
This systematic review summarized the properties and bioactivity of nanoparticles (1-100 nm), covering how their size, shape, and surface characteristics influence their behavior in biological systems and their potential applications in microbiology.
An updated overview of some factors that influence the biological effects of nanoparticles
This review provides an updated look at how the size, shape, chemical composition, and surface properties of nanoparticles influence their biological effects when they enter the body. Researchers summarize how these physical characteristics determine how nanoparticles interact with proteins, cell receptors, and other biological molecules. The study highlights the importance of understanding these factors for both the safe design of medical nanoparticles and for assessing environmental nanoparticle risks.
Current Status and Challenges of Analytical Methods for Evaluation of Size and Surface Modification of Nanoparticle-Based Drug Formulations
Researchers reviewed the analytical methods used to characterize nanoparticle-based drug products — including liposomal therapies and mRNA vaccines — identifying key measurement challenges around polydispersity, non-spherical particles, and surface modifications, and calling for better reference materials and standardization to support next-generation nanomedicine development.
Biomembrane-wrapped gene delivery nanoparticles for cancer therapy
This review examined biomembrane-wrapped nanoparticles as gene delivery vehicles for cancer therapy, highlighting how cell membrane coatings improve targeting, immune evasion, and therapeutic efficacy compared to conventional synthetic delivery systems.
Could Nanotechnology Help to End the Fight Against COVID-19? Review of Current Findings, Challenges and Future Perspectives
This review assessed the potential role of nanotechnology in combating COVID-19, covering nano-enabled diagnostics, drug delivery systems, and vaccines, while noting that most applications were still in early development stages and faced significant regulatory and safety challenges.
Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy
Researchers reviewed how engineering the protein corona — the layer of proteins that coats nanoparticles in biological fluids — through modifications like PEGylation and protein pre-coating can improve nanoparticle targeting for cancer drug delivery by controlling how immune cells recognize and clear the particles.
Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
Researchers reviewed how the physical and chemical properties of nanoparticles — including size, shape, surface charge, and material type — influence their toxicity in living cells and tissues, with relevance to both medical applications and environmental exposures like nanoplastics. Smaller particles are generally more toxic because they have greater surface area and can more easily penetrate cell membranes and trigger oxidative stress.
Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control
Researchers reviewed the benefits and risks of using nanoparticles in pandemic control strategies, including mRNA vaccine delivery, antiviral face masks coated with metal nanoparticles, and biosensors, noting that while nanoparticles offer powerful new tools, they also carry risks such as immune reactions, hormonal disruption, and environmental contamination from improper disposal. The review calls for careful assessment of these trade-offs as nanotechnology becomes more central to public health responses.
All the small things: How virus‐like particles and liposomes modulate allergic immune responses
This review examines how virus-like nanoparticles and liposomes are being engineered as antigen delivery platforms for allergy treatment, discussing their ability to break immunological tolerance against endogenous cytokines and IgE. The authors critically assess the pros and cons of inducing neutralising autoantibodies and review progress toward non-anaphylactogenic particle designs in preclinical and clinical allergy studies.
Nanoparticles in Drug Delivery
This review examines how nanoparticles made from various materials, including polymers, are being developed for targeted drug delivery across biological barriers. Researchers highlighted advances in stimuli-responsive nanoparticle engineering for tumor targeting and the integration of AI models for personalized medicine. While focused on biomedical applications, the study is relevant to understanding how polymer-based particles interact with biological systems at the nanoscale.
A Concise Review of The Role of Nanotechnology, Nanoparticles and Nanomedicine Play in The Diagnostics, Vaccination and Treatment Options For COVID-19
This paper is not about microplastics; it reviews nanotechnology and nanomedicine applications for COVID-19 diagnosis, vaccination, and treatment.
Nanoteknolojinin Tıp ve Mühendislik Uygulamaları
This review covers nanotechnology applications in medicine and engineering, summarizing advancements in nanomaterial development and their utilization across biomedical and engineering domains.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment
Researchers reviewed the evolving field of nanosafety, examining approaches to evaluate the potential toxicity and risks of nanomaterials used across industries including cosmetics, pharmaceuticals, food, and agriculture. The study discusses how traditional toxicological methods are being adapted alongside new nanotoxicology approaches to assess immunotoxicity and genotoxicity of nanomaterials. The review highlights the need for comprehensive safety frameworks as the rapid development of new nanomaterials continues to outpace our understanding of their potential health effects.
Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation
This review covers how tiny chip-like devices called microfluidic systems can be used to manufacture nanoparticles with precise control and then test their safety and effectiveness in realistic lab environments. While focused on medical nanoparticles, the technology is also relevant to studying how nanoplastics behave in biological systems.
Feature of Review Papers in Nanotechnology and Applied Nanosciences
This editorial reviews the characteristics and trends of review papers published in the field of nanotechnology and applied nanosciences, examining how the format and scope of review articles have evolved as the discipline has matured. The authors discuss the role of review papers in synthesizing nanoparticle research across centuries of use and contemporary applications.
The ancillary effects of nanoparticles and their implications for nanomedicine
Researchers reviewed 'ancillary effects' — the unintended biological interactions between nanoparticles and living systems that occur independent of engineered targeting or therapeutic functions — cataloguing how nanomaterial surface properties can modulate cell signaling, immune responses, and toxicity in ways that have major implications for nanomedicine safety and design.
Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review
This review examines nano-carrier systems designed to deliver antibacterial active substances for applications in food packaging, preservation, and other fields. Researchers found that combining natural antimicrobial compounds with nano-carrier materials can substantially improve their stability and effectiveness while reducing microbial resistance, offering promising alternatives to conventional plastic-based approaches.
Efficacy of Nanoparticles in Water Treatment
This overview reviews how engineered nanoparticles can improve conventional water treatment by selectively removing heavy metals, organic pollutants, and pathogens through adsorption and catalytic degradation. While promising, the authors note that the potential toxicity of nanoparticles to humans and ecosystems must be resolved before they can be widely deployed as safe water purification tools.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.
In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials
This review examines in vitro and in vivo models used to assess the immune effects of nanomaterials, comparing cell line, primary cell, and animal model approaches used by regulatory bodies to evaluate immunosafety of drugs, nanomaterials, and environmental contaminants including nanoplastics.
Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations
This review examines emerging approaches for assessing the immunotoxicity of nanomaterials, including nanoplastics, with a focus on vulnerable populations. Researchers describe the evolution from simple cell models to advanced systems that more realistically mimic how the body interacts with nanoparticles, including the role of protein corona formation. The study highlights the need to understand how nanomaterial exposure may shift the immune system toward either inflammatory or tolerant states, using integrated experimental and computational methods.