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20 resultsShowing papers similar to Initial empirical antibiotics of non-carbapenems for ESBL-producing E. coli and K. pneumoniae bacteremia in children: a retrospective medical record review
ClearEmpirical antibiotics of non-carbapenems for ESBL-producing E. coli and K. pneumoniae bacteremia in children : a retrospective medical record review
Researchers retrospectively analyzed clinical outcomes for 53 pediatric patients with ESBL-producing E. coli and K. pneumoniae bacteremia treated with carbapenem or non-carbapenem empirical antibiotics between 2014 and 2019. They found a 30-day all-cause mortality rate of 17%, with 84.6% of non-carbapenem-treated patients switched to carbapenem therapy by day 2, suggesting non-carbapenem empirical therapy was frequently inadequate for this population.
Understanding the clinical and molecular epidemiological characteristics of carbapenem-resistant Acinetobacter baumannii infections within intensive care units of three teaching hospitals
Researchers analyzed carbapenem-resistant Acinetobacter baumannii (CRAB) — a dangerous antibiotic-resistant bacterium — in intensive care units across three hospitals and found it is common and growing increasingly resistant over time. Early identification and aggressive management are critical to stopping its spread in hospital settings.
Multidrug-resistant Escherichia coli causing diarrhea in yak calves on the Qinghai-Tibet Plateau: phenotypic characterization, whole-genome sequencing, and pathogenicity analysis
Scientists found dangerous, drug-resistant E. coli bacteria in sick yak calves in Tibet that doesn't respond to most common antibiotics. These "superbug" strains could potentially spread to humans through the food chain or environment, making infections much harder to treat. This highlights the growing global threat of antibiotic-resistant bacteria, especially in areas where antibiotics are used heavily in livestock.
Hidden threats in the plastisphere: Carbapenemase-producing Enterobacterales colonizing microplastics in river water
Researchers placed microplastics in a river near a wastewater treatment plant and found that antibiotic-resistant bacteria, including dangerous carbapenem-resistant strains, colonized the plastic surfaces. These bacteria carried multiple drug-resistance genes and virulence traits, making them potential threats to human health. The study demonstrates that microplastics in waterways can serve as floating platforms that help spread antibiotic-resistant superbugs from wastewater into the broader environment.
Clinical and diagnostic values of metagenomic next-generation sequencing for infection in hematology patients: a systematic review and meta-analysis
This meta-analysis of 22 studies found that metagenomic next-generation sequencing (mNGS) had a substantially higher pathogen detection rate than conventional microbiological tests in hematology patients, with pooled sensitivity of 87%. The mNGS results led to antibiotic adjustments in about 50% of cases, demonstrating its clinical value for diagnosing infections in immunocompromised patients.
Antibiotic Resistance Pattern in Intensive Care Unit Patients of Bangladesh
This observational study examined antibiotic resistance patterns in intensive care unit patients at a hospital in Bangladesh, characterizing the organisms and resistance profiles of infections in critically ill patients. The study found high rates of multi-drug resistance among ICU pathogens, with implications for empirical treatment protocols in resource-limited settings.
Driving Antibiotic Resistance Evolution of E. coli by Three Commonly Used Disinfectants Under Concentration-Increasing Stress
Scientists found that three common disinfectants (including those used in hospitals and cleaning products) can make E. coli bacteria become resistant to both the disinfectants themselves and important antibiotics when exposed to low concentrations over time. This means that leftover disinfectant residues in our environment might be helping create "superbug" bacteria that are harder to treat with medicines. The findings suggest we need to be more careful about how we use and dispose of disinfectants to prevent creating more antibiotic-resistant infections.
Multiple Bacterial Strategies to Survive Antibiotic Pressure: A Review
This review examined multiple bacterial strategies for surviving antibiotic pressure, including genetic mutations, efflux pumps, biofilm formation, and horizontal gene transfer, highlighting how resistance reservoirs exist beyond hospital settings.
Clinical and diagnostic values of metagenomic next-generation sequencing for infection in hematology patients: a systematic review and meta-analysis
Researchers conducted a systematic review and meta-analysis showing that metagenomic next-generation sequencing (mNGS) — a technology that identifies pathogens by reading their DNA — achieves high detection rates for infections in blood cancer patients. The findings suggest mNGS can guide antibiotic decisions and improve patient outcomes, particularly in China where the evidence base is strongest.
Transmission and Evolution of Antibiotic Resistance Genes and Antibiotic-Resistant Bacteria in Animals, Food, Humans and the Environment
This research review shows that antibiotic-resistant bacteria and their genes are now found everywhere—in people, animals, food, and the environment—not just in hospitals like we used to think. The bacteria can easily share their resistance genes with each other, allowing "superbugs" to spread rapidly between different environments. This matters because it means antibiotic-resistant infections are becoming harder to treat and can reach us through multiple pathways, making it crucial to tackle this problem across all areas of health and the environment at once.
Potential of waterbodies as a reservoir ofEscherichia colipathogens and the spread of antibiotic resistance in the Indonesian aquatic environment
This review analyzes the factors driving the spread of pathogenic Escherichia coli and antibiotic-resistant bacteria in Indonesian aquatic environments, including antibiotic misuse, inadequate waste treatment, and poor industrial waste management. Indonesian rivers serve as vectors for both pathogenic E. coli and antimicrobial resistance genes, posing significant public health risks.
Bacterial colonization dynamics and antibiotic resistance gene dissemination in the hospital environment after first patient occupancy: a longitudinal metagenetic study
Researchers tracked how bacteria and antibiotic resistance genes spread throughout a newly opened hospital ward after its first patients arrived, providing new insights into how clinical environments become colonized with potentially dangerous microbes. The findings could help guide infection control strategies in healthcare facilities.
Are Putative Beta-Lactamases Posing a Potential Future Threat?
Researchers propose a reproducible early warning framework for identifying putative beta-lactamase enzymes that could contribute to future antibiotic resistance. The framework uses motif analysis and mobility context to prioritize candidates and complements existing antimicrobial resistance surveillance systems. The study aligns with a One Health approach that integrates monitoring across human, animal, and environmental reservoirs.
An approach for deriving water quality guideline values for antimicrobials that integrates ecotoxicity and antimicrobial resistance endpoints
Researchers developed an approach for setting water quality guideline values for antimicrobials in Australia and New Zealand that integrates both direct ecotoxicity endpoints and antimicrobial resistance endpoints, addressing a gap in current frameworks that do not account for resistance-promoting environmental concentrations.
Comparative selective pressure potential of antibiotics in the environment
Researchers developed a life-cycle-based framework to compare the antibiotic resistance selection pressure potential of various antibiotics in the environment, finding that measured environmental concentrations of certain antibiotics exceed predicted thresholds for resistance selection.
Differential survival of potentially pathogenic, septicemia- and meningitis-causing E. coli across the wastewater treatment train
Researchers screened E. coli isolates from Canadian wastewater treatment plant effluents and found that 86 isolates carried virulence markers characteristic of extraintestinal pathogenic E. coli (ExPEC) strains capable of causing septicemia and meningitis. Many isolates belonged to pandemic lineages (ST131, ST95, ST73) and survived chlorination, indicating that conventional wastewater treatment does not adequately eliminate clinically important pathogenic E. coli.
Evolution and Emergence of Antibiotic Resistance in Given Ecosystems: Possible Strategies for Addressing the Challenge of Antibiotic Resistance
This review traces the history of antibiotic resistance and examines how it evolves and spreads across aquatic and terrestrial ecosystems. Researchers discuss the ecological roles of antibiotics and the modern tools used to identify resistant organisms in various environments. The study highlights the ecotoxicological impact of antibiotic-resistant bacteria and explores potential strategies, including environmental monitoring, to address this growing public health challenge.
Variability of bile bacterial profiles and drug resistance in patients with choledocholithiasis combined with biliary tract infection: a retrospective study
This retrospective study examined changing patterns of bacterial infections in bile from patients with bile duct stones and biliary tract infections. Researchers found that gram-positive bacterial infections have been increasing over time, while gram-negative bacteria including E. coli have become less common. The findings suggest that antibiotic treatment for these infections should be tailored to reflect current local bacterial profiles.
Panel data analysis of spatial effects carbapenem-resistant organisms in mainland China
Researchers analyzed antibiotic-resistant "superbug" infection rates across 30 Chinese provinces over nearly a decade, finding that carbapenem-resistant bacteria cluster geographically and spread to neighboring regions. Urbanization, healthcare density, and pollution from pesticides and particulate matter (PM2.5) all contributed to the spread, highlighting the need for coordinated cross-regional strategies to contain antibiotic resistance.
Polymyxin Resistance in Salmonella: Exploring Mutations and Genetic Determinants of Non-Human Isolates
Researchers screened over 1,100 Salmonella samples from animals, food, and the environment in Brazil for resistance to polymyxin antibiotics, which are considered last-resort treatments for serious infections. They identified several strains carrying both chromosomal mutations and mobile resistance genes that could spread between bacteria. The findings highlight the growing challenge of antibiotic resistance emerging from non-human sources in the food production chain.