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Initial empirical antibiotics of non-carbapenems for ESBL-producing E. coli and K. pneumoniae bacteremia in children: a retrospective medical record review
Summary
Researchers reviewed medical records of children with bloodstream infections from antibiotic-resistant bacteria and found that starting with non-carbapenem antibiotics — a broader, less powerful class — did not increase mortality risk as long as treatment was quickly adjusted once lab results confirmed the specific bacteria involved.
The empirical use of non-carbapenems might not be a risk factor for mortality and early microbiological outcomes in pediatric patients with ESBL-producing E. coli and K. pneumoniae BSI if early transition to appropriate antimicrobial therapy was possible.
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