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61,005 resultsShowing papers similar to Sciadopitysin attenuates paraquat induced renal toxicity by modulating Nrf2/Keap-1 pathway in male albino rats
ClearRETRACTED ARTICLE: Sciadopitysin mitigates spermatological and testicular damage instigated by paraquat administration in male albino rats
Researchers evaluated whether the flavonoid sciadopitysin could protect against testicular damage caused by paraquat herbicide in rats. The study found that paraquat exposure significantly increased oxidative stress markers and sperm abnormalities, while sciadopitysin treatment helped mitigate these effects by restoring antioxidant enzyme activity. Note: this article has been retracted by the publisher.
Sakuranetin counteracts polyethylene microplastics induced nephrotoxic effects via modulation of Nrf2/Keap1 pathway
Researchers found that polyethylene microplastics caused kidney damage in rats by increasing oxidative stress and disrupting a key protective cellular pathway. However, when the natural plant compound sakuranetin was administered alongside the microplastics, it significantly reduced the kidney damage by restoring antioxidant defenses. The study suggests that certain natural compounds may help counteract some of the harmful effects of microplastic exposure on organ health.
Reno-protective potential of poncirin against polyethylene microplastics instigated kidney damage in rats via regulating Nrf-2/Keap-1 pathway
In a rat study, daily exposure to polyethylene microplastics caused kidney damage — elevated creatinine, urea, and injury biomarkers — while a natural plant compound called poncirin partially reversed this damage by activating the Nrf-2/Keap-1 antioxidant defense pathway. While the doses used were high and results need human validation, the study adds to growing evidence that microplastics can harm the kidneys and that dietary antioxidants may offer some protection.
Mitigative potential of kaempferide against polyethylene microplastics induced testicular damage by activating Nrf-2/Keap-1 pathway
Researchers tested whether kaempferide, a natural plant compound with antioxidant properties, could protect against testicular damage caused by polyethylene microplastics in rats. They found that the microplastics triggered significant oxidative stress and tissue damage in the testes, but kaempferide treatment substantially reduced these harmful effects by activating a key protective cellular pathway. The study suggests that natural antioxidant compounds may help counteract some of the reproductive harm associated with microplastic exposure.
Narirutin ameliorates polystyrene microplastics induced nephrotoxicity by modulating oxidative stress, inflammation and Nrf2/Keap1 pathway
Researchers investigated whether narirutin, a natural compound found in citrus fruits, could protect kidneys from damage caused by polystyrene microplastics in rats. The study suggests that microplastic exposure triggered significant kidney stress through oxidation and inflammation, but narirutin helped reduce that damage by activating protective cellular pathways.
Attenuative effects of tamarixetin against polystyrene microplastics‐induced hepatotoxicity in rats by regulation of Nrf‐2/Keap‐1 pathway
Researchers investigated whether tamarixetin, a naturally occurring flavonoid, could reduce liver damage caused by polystyrene microplastic exposure in rats. The study found that tamarixetin helped protect against microplastic-induced liver toxicity by activating antioxidant defense pathways, suggesting potential protective effects of certain plant-derived compounds against microplastic-related oxidative stress.
Hepatoprotective effects of astragalin against polystyrene microplastics induced hepatic damage in male albino rats by modulating Nrf-2/Keap-1 pathway
Researchers investigated whether astragalin, a natural plant compound, could protect against liver damage caused by polystyrene microplastics in rats. They found that microplastic exposure triggered oxidative stress and inflammation in the liver, but astragalin treatment restored antioxidant enzyme activity and reduced damage. The study suggests that natural compounds may help counteract some of the harmful effects microplastics have on liver health.
Ginkgetin alleviates polystyrene microplastics-instigated liver injury in rats through Nrf-2/Keap-1 pathway activation
The biflavonoid ginkgetin protected rat livers from polystyrene microplastic-induced hepatotoxicity by activating the Nrf2/Keap1 antioxidant signaling pathway, restoring antioxidant enzyme activities and liver function markers at a dose of 25 mg/kg.
Protective role of poncirin against polyethylene microplastics instigatedcardiac toxicity via regulating Nrf2/keap1 pathway
Researchers found that exposing rats to polyethylene microplastics caused significant heart damage — including oxidative stress, inflammation, and cell death — by disrupting the Nrf2 antioxidant defense pathway. Supplementing with poncirin, a natural plant flavonoid, substantially protected cardiac tissue by restoring antioxidant activity, suggesting a potential protective role against microplastic-induced heart toxicity.
Didymin protects against polystyrene nanoplastic-induced hepatic damage in male albino rats by modulation of Nrf-2/Keap-1 pathway
Researchers tested whether didymin, a natural compound found in citrus fruits, could protect rat livers from damage caused by polystyrene nanoplastics. They found that didymin significantly reduced oxidative stress and inflammation by activating a key protective cellular pathway. The study suggests that certain dietary compounds may help counteract some of the harmful effects of nanoplastic exposure on the liver.
Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure
This study tested whether the antioxidant flavonoid quercetin could protect rats from oxidative damage caused by xenobiotic (foreign chemical) exposure, finding that quercetin administration reduced biomarkers of oxidative stress and liver damage. The results suggest that natural antioxidants may help counteract some biochemical effects of environmental chemical exposures.
Natural Pyrethrin-Induced Oxidative Damage in Human Liver Cells through Nrf-2 Signaling Pathway
Researchers investigated the toxic effects of natural pyrethrins, a common bio-pesticide, on human liver cells. The study found that pyrethrins induced oxidative damage through the Nrf-2 signaling pathway, suggesting that even natural pesticides may pose risks to liver metabolism at certain exposure levels.
Evaluation of Possible Ameliorative Role of Robinetin to Counteract Polystyrene Microplastics Instigated Renal Toxicity in Rats
Researchers tested whether robinetin, a plant-derived compound, could protect rat kidneys from damage caused by polystyrene microplastic exposure. They found that microplastics caused significant kidney harm through oxidative stress, inflammation, and cell death, but robinetin supplementation substantially reversed these effects. The study suggests that natural antioxidant compounds may offer a protective strategy against microplastic-related organ damage.
Tea Polyphenols Mitigate TBBPA-Induced Renal Injury Through Modulation of ROS-PI3K/AKT-NF-κB Signalling in Carp (Cyprinus carpio)
Researchers found that tea polyphenols, the beneficial compounds in tea, helped protect carp kidneys from damage caused by the flame retardant chemical TBBPA. The tea compounds reduced oxidative stress, inflammation, and cell death in kidney tissue by modulating key signaling pathways. The study suggests that natural antioxidants like those found in tea may help mitigate some of the harmful effects of environmental chemical pollutants on aquatic organisms.
Pharmacological assessment of delphinidin in counteracting polystyrene microplastic induced renal dysfunction in rats
Researchers investigated whether the plant compound delphinidin could protect against kidney damage caused by polystyrene microplastics in rats. They found that microplastic exposure triggered oxidative stress, inflammation, and cell death markers in kidney tissue, while delphinidin treatment significantly restored normal kidney function. The study suggests that delphinidin may have protective properties against microplastic-induced organ damage in animal models.
Attenuative Effects of Ginkgetin Against Polystyrene Microplastics-Induced Renal Toxicity in Rats
Researchers found that ginkgetin, a natural flavonoid, significantly reduced polystyrene microplastic-induced kidney damage in rats by restoring antioxidant enzyme activity and reducing oxidative stress and inflammation markers.
Rhamnetin abrogates polystyrene microplastics prompted hepatic damage by regulating Nrf-2/Keap-1 pathway
Researchers investigated whether rhamnetin, a natural flavonoid, could protect against liver damage induced by polystyrene microplastics in rats administered 0.01 mg/kg PS-MPs for the experimental period. They found that PS-MPs suppressed the Nrf-2/Keap-1 antioxidant pathway, reduced activities of SOD, CAT, GPx, GST, and HO-1 enzymes, elevated ALT, AST, and ALP liver injury markers, and increased apoptotic signaling, while co-administration of 50 mg/kg rhamnetin mitigated all these effects through hepatoprotective, anti-inflammatory, and antioxidant mechanisms.
Ameliorative Effects of Rhamnetin against Polystyrene Microplastics-Induced Nephrotoxicity in Rats
Researchers investigated whether the flavonoid rhamnetin could protect against kidney damage caused by polystyrene microplastics in rats. The study found that microplastic exposure significantly increased oxidative stress and inflammatory markers while reducing antioxidant enzyme activity, but co-treatment with rhamnetin restored kidney parameters and mitigated the damage.
Cardioprotective potential of sakuranetin to counteract polyethylene microplastics induced cardiotoxicity
The flavonoid sakuranetin protected rat hearts from polyethylene microplastic-induced cardiotoxicity by activating the Nrf2/Keap1 antioxidant pathway, restoring cardiac biomarker levels and reducing oxidative damage caused by 30 days of microplastic exposure.
Attenuative effects of poncirin against polyethylene microplastics-prompted hepatotoxicity in rats
Researchers tested whether poncirin, a natural plant compound, could protect rat livers from damage caused by polyethylene microplastics. They found that microplastic exposure caused significant oxidative stress, inflammation, and liver tissue damage, which poncirin was able to substantially reduce by activating protective antioxidant pathways. The study suggests that natural compounds like poncirin may help counteract some of the harmful effects of microplastic exposure on the liver.
Clusterin Protects Against Cr(VI)-Induced Oxidative Stress-Associated Hepatotoxicity By Mediating The Akt-Keap1-Nrf2 Signaling Pathway
Hexavalent chromium, a toxic industrial pollutant, causes liver damage partly through oxidative stress. This study found that the protein clusterin helps protect liver cells from chromium-induced injury by activating a key antioxidant signaling pathway.
Protective Effect of Resveratrol on Kidney Disease and Hypertension Against Microplastics Exposure in Male Juvenile Rats
Researchers investigated whether resveratrol, a natural plant compound, could protect young rats from kidney damage and high blood pressure caused by microplastic exposure. They found that microplastics elevated blood pressure and creatinine levels through oxidative stress, and that resveratrol treatment effectively prevented these effects. The study suggests resveratrol may offer protective benefits against organ damage linked to microplastic exposure, partly by improving gut microbiota balance.
Protective effects of herbacetin against polystyrene microplastics-instigated liver damage in rats
Researchers investigated the protective effects of herbacetin, a natural flavonoid, against liver damage caused by polystyrene microplastic exposure in rats. The study found that herbacetin helped restore antioxidant enzyme levels and reduce inflammation markers, suggesting it may offer some protection against microplastic-associated oxidative stress in liver tissue.
Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats
Researchers showed that arsenic — a heavy metal contaminant found alongside plastic pollution in many environments — severely damages sperm quality and hormone levels in male rats, and that the plant compound fisetin significantly reversed this damage. The results suggest fisetin may help protect male reproductive health from toxic environmental exposures.