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Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure
Summary
This study tested whether the antioxidant flavonoid quercetin could protect rats from oxidative damage caused by xenobiotic (foreign chemical) exposure, finding that quercetin administration reduced biomarkers of oxidative stress and liver damage. The results suggest that natural antioxidants may help counteract some biochemical effects of environmental chemical exposures.
The objective of this study is to determine the possibility of correcting pathological disorders of the oxidative-antioxidant system in the rat organism under the influence of xenobiotics using the flavonoid quercetin, which has an antioxidant, anti-inflammatory, antibacterial, antiviral and immunomodulating effect. Baseline studies have established that when exposed to xenobiotics at a dose of 1/10 and 1/100 DL50, the content of lipid peroxidation products in the serum of rats increases, including 8-isoprostane, TBA-active products (TBA-AP) and diene conjugates (DK). As a result, the state of the antioxidant system also undergoes changes, evidenced by a decrease in catalase activity under the action of xenobiotics in doses of 1/10 and 1/100 DL50, as well as fluctuations in superoxide dismutase content, namely: a decrease under the influence of xenobiotics in a dose of 1/10 DL50 and increase with the action of substances in a dose of 1/100 DL50. After correction with the flavonoid quercetin, a decrease in the content of both primary and secondary POL products in the rat organism, as well as indicators of the state of the oxidative-antioxidant system was established. At the same time, an important for clinical practice relationship was established between the degree of correction of pathological changes in the state of the oxidative-antioxidant system and the dose of toxic effects of xenobiotics. After intragastric administration of “Quertin” in a dose of 25 mg/kg of body weight to rats exposed to polyethylene glycol 400 at a dose of 1/10 DL50, a decrease in serum levels of 8-isoprostan was determined by 14.5%, TBA-AP – by 17.3%, DK – by 15.5%. After exposure to polyethylene glycol 400 at a dose of 1/100 DL50, the content of 8-isoprostane decreased by 12.4%, TBА-AP by 16.8%, and DK by 11.8%. After exposure to polypropylene glycol in doses of 1/10 and 1/100 DL50, the content of 8-isoprostane decreased by 17.7% and 12.5%, TBA-AP – 11.7% and 9.8%, DK – 16.3% and 12.7% respectively. After exposure to ethylene glycol in doses of 1/10 and 1/100 DL50, the content of 8-isoprostane decreased by 22.1% and 14.9%, TBA-AP – 17.3% and 15.2%, DK – 17.6% and 12.2% respectively. Catalase activity increased after the correction by “Quertin” at exposure to polyethylene glycol 400 at doses 1/10 and 1/100 DL50, respectively, by 25.8% and 20.6%; polypropylene glycol – by 26.5% and 23.4%; ethylene glycol – by 19.4% and 15.6%. Superoxide dismutase activity in the blood of rats after the correction of “Quertin” increased at xenobiotic toxification at a dose of 1/10 DL50 (polyethylene glycol 400 – by 29.3%, polypropylene glycol – by 33.5%; ethylene glycol – by 23.2%) and decreased at toxification with xenobiotics at a dose of 1/100 DL50 (polyethylene glycol 400 – by 21.6%, polypropylene glycol – by 26.7%; ethylene glycol – by 18.6%).
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