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Attenuative Effects of Ginkgetin Against Polystyrene Microplastics-Induced Renal Toxicity in Rats
Summary
Researchers found that ginkgetin, a natural flavonoid, significantly reduced polystyrene microplastic-induced kidney damage in rats by restoring antioxidant enzyme activity and reducing oxidative stress and inflammation markers.
The present study was designed to evaluate the palliative potential of ginkgetin (GK) against polystyrene microplastics (PS-MPs) instigated renal damage in rats.24 rats were separated into 4 groups i.e., control, PS-MPs-intoxicated (0.01mgkg -1 ), PS-MPs (0.01mgkg -1 ) and GK (25mgkg -1 ) administrated and GK (25mgkg -1 ) only treated group.Results of the experiment showed that the activities of anti-oxidant enzymes i.e., glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GSR) & catalase (CAT) were significantly decreased, while the levels of ROS and MDA were increased following PS-MPs treatment.Furthermore, PS-MPs intoxication increased the levels of kidney function markers such as creatinine, urea, NGAL and KIM-1, while a significant reduction was observed in creatinine clearance.Moreover, PS-MPs significantly increased the TNF-α, NF-κB, IL-6, IL-1β levels and COX-2 activity.Furthermore, it reduced the Bcl-2 level, while increasing the levels of Caspase-9, Bax and Caspase-3 and induced histological damages in the renal tissues.However, the treatment of GK significantly regulated the biochemical, renal, inflammatory, apoptotic markers and attenuated the PS-MPs induced histopathological damages due to its reno-protective, anti-apoptotic, anti-oxidant and anti-inflammatory nature.
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