We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Attenuative Effects of Ginkgetin Against Polystyrene Microplastics-Induced Renal Toxicity in Rats
AI summary Read the abstract
Researchers found that ginkgetin, a natural flavonoid, significantly reduced polystyrene microplastic-induced kidney damage in rats by restoring antioxidant enzyme activity and reducing oxidative stress and inflammation markers.
The present study was designed to evaluate the palliative potential of ginkgetin (GK) against polystyrene microplastics (PS-MPs) instigated renal damage in rats.24 rats were separated into 4 groups i.e., control, PS-MPs-intoxicated (0.01mgkg -1 ), PS-MPs (0.01mgkg -1 ) and GK (25mgkg -1 ) administrated and GK (25mgkg -1 ) only treated group.Results of the experiment showed that the activities of anti-oxidant enzymes i.e., glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GSR) & catalase (CAT) were significantly decreased, while the levels of ROS and MDA were increased following PS-MPs treatment.Furthermore, PS-MPs intoxication increased the levels of kidney function markers such as creatinine, urea, NGAL and KIM-1, while a significant reduction was observed in creatinine clearance.Moreover, PS-MPs significantly increased the TNF-α, NF-κB, IL-6, IL-1β levels and COX-2 activity.Furthermore, it reduced the Bcl-2 level, while increasing the levels of Caspase-9, Bax and Caspase-3 and induced histological damages in the renal tissues.However, the treatment of GK significantly regulated the biochemical, renal, inflammatory, apoptotic markers and attenuated the PS-MPs induced histopathological damages due to its reno-protective, anti-apoptotic, anti-oxidant and anti-inflammatory nature.
More Papers Like This
Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics–instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment
AI summary Read the abstract
Forty-eight male rats were given polystyrene microplastics, ginkgetin, both or neither for 56 days. Microplastics lowered antioxidant enzyme activity in the testes and reduced sperm count, viability and motility. Rats that also received ginkgetin, a plant biflavonoid, showed less of this damage.
Ginkgetin alleviates polystyrene microplastics-instigated liver injury in rats through Nrf-2/Keap-1 pathway activation
AI summary Read the abstract
The biflavonoid ginkgetin protected rat livers from polystyrene microplastic-induced hepatotoxicity by activating the Nrf2/Keap1 antioxidant signaling pathway, restoring antioxidant enzyme activities and liver function markers at a dose of 25 mg/kg.
Ameliorative Effects of Rhamnetin against Polystyrene Microplastics-Induced Nephrotoxicity in Rats
AI summary Read the abstract
Researchers investigated whether the flavonoid rhamnetin could protect against kidney damage caused by polystyrene microplastics in rats. The study found that microplastic exposure significantly increased oxidative stress and inflammatory markers while reducing antioxidant enzyme activity, but co-treatment with rhamnetin restored kidney parameters and mitigated the damage.
Evaluation of Possible Ameliorative Role of Robinetin to Counteract Polystyrene Microplastics Instigated Renal Toxicity in Rats
AI summary Read the abstract
Twenty-four rats were given polystyrene microplastics, robinetin, both or neither. Microplastics lowered antioxidant enzyme activity in the kidney and raised markers of kidney injury, inflammation and cell death. Rats that also received robinetin, a plant flavonoid, had values closer to those of the control group.
Pharmacological assessment of delphinidin in counteracting polystyrene microplastic induced renal dysfunction in rats
AI summary Read the abstract
Researchers investigated whether the plant compound delphinidin could protect against kidney damage caused by polystyrene microplastics in rats. They found that microplastic exposure triggered oxidative stress, inflammation, and cell death markers in kidney tissue, while delphinidin treatment significantly restored normal kidney function. The study suggests that delphinidin may have protective properties against microplastic-induced organ damage in animal models.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.